TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma

Most melanoma patients do not respond to anti-PD1 therapy. Here, the authors show that TNFα blockade synergizes with anti-PD-1 by preventing anti-PD-1-induced CD8+ T cell death and TIM-3 expression on such cells.

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Autores principales:	Florie Bertrand, Anne Montfort, Elie Marcheteau, Caroline Imbert, Julia Gilhodes, Thomas Filleron, Philippe Rochaix, Nathalie Andrieu-Abadie, Thierry Levade, Nicolas Meyer, Céline Colacios, Bruno Ségui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a4452c1e969c432987f7e542b52dfbb2
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spelling	oai:doaj.org-article:a4452c1e969c432987f7e542b52dfbb22021-12-02T14:42:01ZTNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma10.1038/s41467-017-02358-72041-1723https://doaj.org/article/a4452c1e969c432987f7e542b52dfbb22017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02358-7https://doaj.org/toc/2041-1723Most melanoma patients do not respond to anti-PD1 therapy. Here, the authors show that TNFα blockade synergizes with anti-PD-1 by preventing anti-PD-1-induced CD8+ T cell death and TIM-3 expression on such cells.Florie BertrandAnne MontfortElie MarcheteauCaroline ImbertJulia GilhodesThomas FilleronPhilippe RochaixNathalie Andrieu-AbadieThierry LevadeNicolas MeyerCéline ColaciosBruno SéguiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Florie Bertrand Anne Montfort Elie Marcheteau Caroline Imbert Julia Gilhodes Thomas Filleron Philippe Rochaix Nathalie Andrieu-Abadie Thierry Levade Nicolas Meyer Céline Colacios Bruno Ségui TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma
description	Most melanoma patients do not respond to anti-PD1 therapy. Here, the authors show that TNFα blockade synergizes with anti-PD-1 by preventing anti-PD-1-induced CD8+ T cell death and TIM-3 expression on such cells.
format	article
author	Florie Bertrand Anne Montfort Elie Marcheteau Caroline Imbert Julia Gilhodes Thomas Filleron Philippe Rochaix Nathalie Andrieu-Abadie Thierry Levade Nicolas Meyer Céline Colacios Bruno Ségui
author_facet	Florie Bertrand Anne Montfort Elie Marcheteau Caroline Imbert Julia Gilhodes Thomas Filleron Philippe Rochaix Nathalie Andrieu-Abadie Thierry Levade Nicolas Meyer Céline Colacios Bruno Ségui
author_sort	Florie Bertrand
title	TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma
title_short	TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma
title_full	TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma
title_fullStr	TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma
title_full_unstemmed	TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma
title_sort	tnfα blockade overcomes resistance to anti-pd-1 in experimental melanoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a4452c1e969c432987f7e542b52dfbb2
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TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma

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