Local and systemic cytokine expression in patients with postherpetic neuralgia.

<h4>Background</h4>Postherpetic neuralgia (PHN) is the painful complication of a varicella zoster virus reactivation. We investigated the systemic and local gene expression of pro- and anti-inflammatory cytokine expression in patients with PHN.<h4>Methods</h4>Thirteen patient...

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Autores principales:	Nurcan Üçeyler, Michael Valet, Waldemar Kafke, Thomas R Tölle, Claudia Sommer
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a4468f07bcdf492e86a3232bfc43d92a
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spelling	oai:doaj.org-article:a4468f07bcdf492e86a3232bfc43d92a2021-11-25T06:04:34ZLocal and systemic cytokine expression in patients with postherpetic neuralgia.1932-620310.1371/journal.pone.0105269https://doaj.org/article/a4468f07bcdf492e86a3232bfc43d92a2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25127283/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Postherpetic neuralgia (PHN) is the painful complication of a varicella zoster virus reactivation. We investigated the systemic and local gene expression of pro- and anti-inflammatory cytokine expression in patients with PHN.<h4>Methods</h4>Thirteen patients with PHN at the torso (Th4-S1) were recruited. Skin punch biopsies were obtained from the painful and the contralateral painless body area for intraepidermal nerve fiber density (IENFD) and cytokine profiling. Additionally, blood was withdrawn for systemic cytokine expression and compared to blood values of healthy controls. We analyzed the gene expression of selected pro- and anti-inflammatory cytokines (tumor necrosis factor-alpha [TNF] and interleukins [IL]-1β, IL-2, and IL-8).<h4>Results</h4>IENFD was lower in affected skin compared to unaffected skin (p<0.05), while local gene expression of pro- and anti-inflammatory cytokines did not differ except for two patients who had 7fold higher IL-6 and 10fold higher IL-10 gene expression in the affected skin compared to the contralateral unaffected skin sample. Also, the systemic expression of cytokines in patients with PHN and in healthy controls was similar.<h4>Conclusion</h4>While the systemic and local expression of the investigated pro- and anti-inflammatory cytokines was not different from controls, this may have been influenced by study limitations like the low number of patients and different disease durations. Furthermore, other cytokines or pain mediators need to be considered.Nurcan ÜçeylerMichael ValetWaldemar KafkeThomas R TölleClaudia SommerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e105269 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nurcan Üçeyler Michael Valet Waldemar Kafke Thomas R Tölle Claudia Sommer Local and systemic cytokine expression in patients with postherpetic neuralgia.
description	<h4>Background</h4>Postherpetic neuralgia (PHN) is the painful complication of a varicella zoster virus reactivation. We investigated the systemic and local gene expression of pro- and anti-inflammatory cytokine expression in patients with PHN.<h4>Methods</h4>Thirteen patients with PHN at the torso (Th4-S1) were recruited. Skin punch biopsies were obtained from the painful and the contralateral painless body area for intraepidermal nerve fiber density (IENFD) and cytokine profiling. Additionally, blood was withdrawn for systemic cytokine expression and compared to blood values of healthy controls. We analyzed the gene expression of selected pro- and anti-inflammatory cytokines (tumor necrosis factor-alpha [TNF] and interleukins [IL]-1β, IL-2, and IL-8).<h4>Results</h4>IENFD was lower in affected skin compared to unaffected skin (p<0.05), while local gene expression of pro- and anti-inflammatory cytokines did not differ except for two patients who had 7fold higher IL-6 and 10fold higher IL-10 gene expression in the affected skin compared to the contralateral unaffected skin sample. Also, the systemic expression of cytokines in patients with PHN and in healthy controls was similar.<h4>Conclusion</h4>While the systemic and local expression of the investigated pro- and anti-inflammatory cytokines was not different from controls, this may have been influenced by study limitations like the low number of patients and different disease durations. Furthermore, other cytokines or pain mediators need to be considered.
format	article
author	Nurcan Üçeyler Michael Valet Waldemar Kafke Thomas R Tölle Claudia Sommer
author_facet	Nurcan Üçeyler Michael Valet Waldemar Kafke Thomas R Tölle Claudia Sommer
author_sort	Nurcan Üçeyler
title	Local and systemic cytokine expression in patients with postherpetic neuralgia.
title_short	Local and systemic cytokine expression in patients with postherpetic neuralgia.
title_full	Local and systemic cytokine expression in patients with postherpetic neuralgia.
title_fullStr	Local and systemic cytokine expression in patients with postherpetic neuralgia.
title_full_unstemmed	Local and systemic cytokine expression in patients with postherpetic neuralgia.
title_sort	local and systemic cytokine expression in patients with postherpetic neuralgia.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/a4468f07bcdf492e86a3232bfc43d92a
work_keys_str_mv	AT nurcanuceyler localandsystemiccytokineexpressioninpatientswithpostherpeticneuralgia AT michaelvalet localandsystemiccytokineexpressioninpatientswithpostherpeticneuralgia AT waldemarkafke localandsystemiccytokineexpressioninpatientswithpostherpeticneuralgia AT thomasrtolle localandsystemiccytokineexpressioninpatientswithpostherpeticneuralgia AT claudiasommer localandsystemiccytokineexpressioninpatientswithpostherpeticneuralgia
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Local and systemic cytokine expression in patients with postherpetic neuralgia.

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