Study on inflammatory factors and curative effect of Rhizoma Imperata on community acquired pneumonia based on TLR4/NF-κB signaling pathway
Objective: To investigate the curative effect of Rhizoma Imperata in the treatment of patients with community-acquired pneumonia and its influence on inflammatory factors related to TLR4/NF-κB signaling pathway, so as to seek new drugs for the treatment of communityacquired pneumonia. Methods: 12...
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Editorial Board of Journal of Hainan Medical University
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/a448606c65cf4b3a82a4d13089270216 |
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| Sumario: | Objective: To investigate the curative effect of Rhizoma Imperata in the treatment of patients
with community-acquired pneumonia and its influence on inflammatory factors related to
TLR4/NF-κB signaling pathway, so as to seek new drugs for the treatment of communityacquired
pneumonia. Methods: 120 patients with community-acquired pneumonia who were
treated in Department of respiratory medicine, the First Affiliated Hospital of Hainan Medical
College from November 2019 to September 2020 were collected and randomly divided into
control group and experimental group, with 60 patients in each group. The control group
was given cefuroxime sodium injection, and the experimental group was given cefuroxime
sodium injection + Baimao root decoction. The levels of high-sensitivity C-reactive protein
(CRP) and the level of serum CRP in the two groups before and after treatment were compared
Objective To observe the expression of procalcitonin(PCT), IL-6, IL-8, TNF-αand TLR4/
NF-κB mRNA levels, and to observe the effect of Radix Imperata Rubra on communityacquired
pneumonia. Results: The fever, cough, expectoration subsided time and chest CT
inflammation absorption time of the experimental group were shorter than those of the control
group, the difference was statistically significant (P<0.05); the total effective rate of the
experimental group(96.67%) was higher than that of the control group(85%), the difference
was statistically significant(P<0.05); after treatment, the serum CRP, PCT, IL-6, IL-8, TNF-
αin the two groups were lower than before, and the experimental group was significantly lower
than the control group, the difference was statistically significant(P<0.05),There was statistical
significance(P<0.05); after treatment, TLR4/NF-κB mRNA of the two groups were decreased,
and the experimental group was significantly lower than the control group, the difference was
statistically significant(P<0.05). Conclusion: In the treatment of cap, Rhizoma Imperata can
reduce the levels of CRP, PCT, IL-6, IL-8 and TNF-α. The mechanism is related to inhibiting
the activation of TLR4/NF-κB signaling pathway,so as to reduce the release of inflammatory
factors and improve clinical symptoms. |
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