Study on inflammatory factors and curative effect of Rhizoma Imperata on community acquired pneumonia based on TLR4/NF-κB signaling pathway

Objective: To investigate the curative effect of Rhizoma Imperata in the treatment of patients with community-acquired pneumonia and its influence on inflammatory factors related to TLR4/NF-κB signaling pathway, so as to seek new drugs for the treatment of communityacquired pneumonia. Methods: 12...

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Autores principales:	Qiu-Cheng Li, Xiang-Dong Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Editorial Board of Journal of Hainan Medical University 2021
Materias:	rhizoma imperata community acquired pneumonia tlr4 nf-κb curative effect Medicine R
Acceso en línea:	https://doaj.org/article/a448606c65cf4b3a82a4d13089270216
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spelling	oai:doaj.org-article:a448606c65cf4b3a82a4d130892702162021-12-01T05:13:07ZStudy on inflammatory factors and curative effect of Rhizoma Imperata on community acquired pneumonia based on TLR4/NF-κB signaling pathway1007-1237https://doaj.org/article/a448606c65cf4b3a82a4d130892702162021-10-01T00:00:00Zhttp://www.hnykdxxb.com/PDF/202120/06.pdfhttps://doaj.org/toc/1007-1237Objective: To investigate the curative effect of Rhizoma Imperata in the treatment of patients with community-acquired pneumonia and its influence on inflammatory factors related to TLR4/NF-κB signaling pathway, so as to seek new drugs for the treatment of communityacquired pneumonia. Methods: 120 patients with community-acquired pneumonia who were treated in Department of respiratory medicine, the First Affiliated Hospital of Hainan Medical College from November 2019 to September 2020 were collected and randomly divided into control group and experimental group, with 60 patients in each group. The control group was given cefuroxime sodium injection, and the experimental group was given cefuroxime sodium injection + Baimao root decoction. The levels of high-sensitivity C-reactive protein (CRP) and the level of serum CRP in the two groups before and after treatment were compared Objective To observe the expression of procalcitonin(PCT), IL-6, IL-8, TNF-αand TLR4/ NF-κB mRNA levels, and to observe the effect of Radix Imperata Rubra on communityacquired pneumonia. Results: The fever, cough, expectoration subsided time and chest CT inflammation absorption time of the experimental group were shorter than those of the control group, the difference was statistically significant (P<0.05); the total effective rate of the experimental group(96.67%) was higher than that of the control group(85%), the difference was statistically significant(P<0.05); after treatment, the serum CRP, PCT, IL-6, IL-8, TNF- αin the two groups were lower than before, and the experimental group was significantly lower than the control group, the difference was statistically significant(P<0.05),There was statistical significance(P<0.05); after treatment, TLR4/NF-κB mRNA of the two groups were decreased, and the experimental group was significantly lower than the control group, the difference was statistically significant(P<0.05). Conclusion: In the treatment of cap, Rhizoma Imperata can reduce the levels of CRP, PCT, IL-6, IL-8 and TNF-α. The mechanism is related to inhibiting the activation of TLR4/NF-κB signaling pathway,so as to reduce the release of inflammatory factors and improve clinical symptoms.Qiu-Cheng LiXiang-Dong ZhouEditorial Board of Journal of Hainan Medical Universityarticlerhizoma imperatacommunity acquired pneumoniatlr4nf-κbcurative effectMedicineRENJournal of Hainan Medical University, Vol 27, Iss 20, Pp 25-29 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	rhizoma imperata community acquired pneumonia tlr4 nf-κb curative effect Medicine R
spellingShingle	rhizoma imperata community acquired pneumonia tlr4 nf-κb curative effect Medicine R Qiu-Cheng Li Xiang-Dong Zhou Study on inflammatory factors and curative effect of Rhizoma Imperata on community acquired pneumonia based on TLR4/NF-κB signaling pathway
description	Objective: To investigate the curative effect of Rhizoma Imperata in the treatment of patients with community-acquired pneumonia and its influence on inflammatory factors related to TLR4/NF-κB signaling pathway, so as to seek new drugs for the treatment of communityacquired pneumonia. Methods: 120 patients with community-acquired pneumonia who were treated in Department of respiratory medicine, the First Affiliated Hospital of Hainan Medical College from November 2019 to September 2020 were collected and randomly divided into control group and experimental group, with 60 patients in each group. The control group was given cefuroxime sodium injection, and the experimental group was given cefuroxime sodium injection + Baimao root decoction. The levels of high-sensitivity C-reactive protein (CRP) and the level of serum CRP in the two groups before and after treatment were compared Objective To observe the expression of procalcitonin(PCT), IL-6, IL-8, TNF-αand TLR4/ NF-κB mRNA levels, and to observe the effect of Radix Imperata Rubra on communityacquired pneumonia. Results: The fever, cough, expectoration subsided time and chest CT inflammation absorption time of the experimental group were shorter than those of the control group, the difference was statistically significant (P<0.05); the total effective rate of the experimental group(96.67%) was higher than that of the control group(85%), the difference was statistically significant(P<0.05); after treatment, the serum CRP, PCT, IL-6, IL-8, TNF- αin the two groups were lower than before, and the experimental group was significantly lower than the control group, the difference was statistically significant(P<0.05),There was statistical significance(P<0.05); after treatment, TLR4/NF-κB mRNA of the two groups were decreased, and the experimental group was significantly lower than the control group, the difference was statistically significant(P<0.05). Conclusion: In the treatment of cap, Rhizoma Imperata can reduce the levels of CRP, PCT, IL-6, IL-8 and TNF-α. The mechanism is related to inhibiting the activation of TLR4/NF-κB signaling pathway,so as to reduce the release of inflammatory factors and improve clinical symptoms.
format	article
author	Qiu-Cheng Li Xiang-Dong Zhou
author_facet	Qiu-Cheng Li Xiang-Dong Zhou
author_sort	Qiu-Cheng Li
title	Study on inflammatory factors and curative effect of Rhizoma Imperata on community acquired pneumonia based on TLR4/NF-κB signaling pathway
title_short	Study on inflammatory factors and curative effect of Rhizoma Imperata on community acquired pneumonia based on TLR4/NF-κB signaling pathway
title_full	Study on inflammatory factors and curative effect of Rhizoma Imperata on community acquired pneumonia based on TLR4/NF-κB signaling pathway
title_fullStr	Study on inflammatory factors and curative effect of Rhizoma Imperata on community acquired pneumonia based on TLR4/NF-κB signaling pathway
title_full_unstemmed	Study on inflammatory factors and curative effect of Rhizoma Imperata on community acquired pneumonia based on TLR4/NF-κB signaling pathway
title_sort	study on inflammatory factors and curative effect of rhizoma imperata on community acquired pneumonia based on tlr4/nf-κb signaling pathway
publisher	Editorial Board of Journal of Hainan Medical University
publishDate	2021
url	https://doaj.org/article/a448606c65cf4b3a82a4d13089270216
work_keys_str_mv	AT qiuchengli studyoninflammatoryfactorsandcurativeeffectofrhizomaimperataoncommunityacquiredpneumoniabasedontlr4nfkbsignalingpathway AT xiangdongzhou studyoninflammatoryfactorsandcurativeeffectofrhizomaimperataoncommunityacquiredpneumoniabasedontlr4nfkbsignalingpathway
_version_	1718405561919209472

Study on inflammatory factors and curative effect of Rhizoma Imperata on community acquired pneumonia based on TLR4/NF-κB signaling pathway

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