Gadolinium3+-doped mesoporous silica nanoparticles as a potential magnetic resonance tracer for monitoring the migration of stem cells in vivo

Yingying Shen,1,2,* Yuanzhi Shao,3,* Haoqiang He,1 Yunpu Tan,4 Xiumei Tian,2 Fukang Xie,2 Li Li11Imaging Diagnostic and Interventional Center, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China; 2Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen Univers...

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Autores principales:	Tian X, Tan Y, He H, Shao Y, Shen Y, Xie F, Li L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a450309c365647d0b5602aa18afd9046
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spelling	oai:doaj.org-article:a450309c365647d0b5602aa18afd90462021-12-02T04:46:25ZGadolinium3+-doped mesoporous silica nanoparticles as a potential magnetic resonance tracer for monitoring the migration of stem cells in vivo1176-91141178-2013https://doaj.org/article/a450309c365647d0b5602aa18afd90462013-01-01T00:00:00Zhttp://www.dovepress.com/gadolinium3-doped-mesoporous-silica-nanoparticles-as-a-potential-magne-a11861https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Yingying Shen,1,2,* Yuanzhi Shao,3,* Haoqiang He,1 Yunpu Tan,4 Xiumei Tian,2 Fukang Xie,2 Li Li11Imaging Diagnostic and Interventional Center, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China; 2Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China; 3Key Laboratory of Optoelectronic Materials and Technologies, School of Physics and Engineering, Sun Yat-sen University, Guangzhou, Guangdong, China; 4Department of Gastrointestinal Surgery, Sun Yat-sen University, Guangzhou, Guangdong, China *These authors contributed equally to this workAbstract: We investigated the tracking potential of a magnetic resonance imaging (MRI) probe made of gadolinium-doped mesoporous silica MCM-41 (Gd2O3@MCM-41) nanoparticles for transplanted bone mesenchymal stem cells (MSCs) and neural stem cells (NSCs) in vivo. The nanoparticles, synthesized using a one-step synthetic method, possess hexagonal mesoporous structures with appropriate assembly of nanoscale Gd2O3 clusters. They show little cytotoxicity against proliferation and have a lower effect on the inherent differentiation potential of these labeled stem cells. The tracking of labeled NSCs in murine brains was dynamically determined with a clinical 3T MRI system for at least 14 days. The migration of labeled NSCs identified by MRI corresponded to the results of immunofluorescence imaging. Our study confirms that Gd2O3@MCM-41 particles can serve as an ideal vector for long-term MRI tracking of MSCs and NSCs in vivo.Keywords: nanoparticles, gadolinium, magnetic resonance imaging, stem cellsTian XTan YHe HShao YShen YXie FLi LDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 119-127 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Tian X Tan Y He H Shao Y Shen Y Xie F Li L Gadolinium3+-doped mesoporous silica nanoparticles as a potential magnetic resonance tracer for monitoring the migration of stem cells in vivo
description	Yingying Shen,1,2,* Yuanzhi Shao,3,* Haoqiang He,1 Yunpu Tan,4 Xiumei Tian,2 Fukang Xie,2 Li Li11Imaging Diagnostic and Interventional Center, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China; 2Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China; 3Key Laboratory of Optoelectronic Materials and Technologies, School of Physics and Engineering, Sun Yat-sen University, Guangzhou, Guangdong, China; 4Department of Gastrointestinal Surgery, Sun Yat-sen University, Guangzhou, Guangdong, China *These authors contributed equally to this workAbstract: We investigated the tracking potential of a magnetic resonance imaging (MRI) probe made of gadolinium-doped mesoporous silica MCM-41 (Gd2O3@MCM-41) nanoparticles for transplanted bone mesenchymal stem cells (MSCs) and neural stem cells (NSCs) in vivo. The nanoparticles, synthesized using a one-step synthetic method, possess hexagonal mesoporous structures with appropriate assembly of nanoscale Gd2O3 clusters. They show little cytotoxicity against proliferation and have a lower effect on the inherent differentiation potential of these labeled stem cells. The tracking of labeled NSCs in murine brains was dynamically determined with a clinical 3T MRI system for at least 14 days. The migration of labeled NSCs identified by MRI corresponded to the results of immunofluorescence imaging. Our study confirms that Gd2O3@MCM-41 particles can serve as an ideal vector for long-term MRI tracking of MSCs and NSCs in vivo.Keywords: nanoparticles, gadolinium, magnetic resonance imaging, stem cells
format	article
author	Tian X Tan Y He H Shao Y Shen Y Xie F Li L
author_facet	Tian X Tan Y He H Shao Y Shen Y Xie F Li L
author_sort	Tian X
title	Gadolinium3+-doped mesoporous silica nanoparticles as a potential magnetic resonance tracer for monitoring the migration of stem cells in vivo
title_short	Gadolinium3+-doped mesoporous silica nanoparticles as a potential magnetic resonance tracer for monitoring the migration of stem cells in vivo
title_full	Gadolinium3+-doped mesoporous silica nanoparticles as a potential magnetic resonance tracer for monitoring the migration of stem cells in vivo
title_fullStr	Gadolinium3+-doped mesoporous silica nanoparticles as a potential magnetic resonance tracer for monitoring the migration of stem cells in vivo
title_full_unstemmed	Gadolinium3+-doped mesoporous silica nanoparticles as a potential magnetic resonance tracer for monitoring the migration of stem cells in vivo
title_sort	gadolinium3+-doped mesoporous silica nanoparticles as a potential magnetic resonance tracer for monitoring the migration of stem cells in vivo
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/a450309c365647d0b5602aa18afd9046
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Gadolinium3+-doped mesoporous silica nanoparticles as a potential magnetic resonance tracer for monitoring the migration of stem cells in vivo

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