Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential
Cellular stressors can impact clonal hematopoiesis. Here, the authors explore the impact of cytotoxic therapy and hematopoietic transplantation on clonal expansion, suggesting different stressors can promote expansion of distinct long-lived clones.
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Nature Portfolio
2018
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oai:doaj.org-article:a452ad93f9a248dab38fccf1d73841842021-12-02T16:49:16ZCellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential10.1038/s41467-018-02858-02041-1723https://doaj.org/article/a452ad93f9a248dab38fccf1d73841842018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02858-0https://doaj.org/toc/2041-1723Cellular stressors can impact clonal hematopoiesis. Here, the authors explore the impact of cytotoxic therapy and hematopoietic transplantation on clonal expansion, suggesting different stressors can promote expansion of distinct long-lived clones.Terrence N. WongChristopher A. MillerMatthew R. M. JotteNusayba BagegniJack D. BatyAmy P. SchmidtAmanda F. CashenEric J. DuncavageNichole M. HeltonMark FialaRobert S. FultonSharon E. HeathMegan JankeKierstin LuberPeter WesterveltRavi VijJohn F. DiPersioJohn S. WelchTimothy A. GraubertMatthew J. WalterTimothy J. LeyDaniel C. LinkNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Terrence N. Wong Christopher A. Miller Matthew R. M. Jotte Nusayba Bagegni Jack D. Baty Amy P. Schmidt Amanda F. Cashen Eric J. Duncavage Nichole M. Helton Mark Fiala Robert S. Fulton Sharon E. Heath Megan Janke Kierstin Luber Peter Westervelt Ravi Vij John F. DiPersio John S. Welch Timothy A. Graubert Matthew J. Walter Timothy J. Ley Daniel C. Link Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential |
| description |
Cellular stressors can impact clonal hematopoiesis. Here, the authors explore the impact of cytotoxic therapy and hematopoietic transplantation on clonal expansion, suggesting different stressors can promote expansion of distinct long-lived clones. |
| format |
article |
| author |
Terrence N. Wong Christopher A. Miller Matthew R. M. Jotte Nusayba Bagegni Jack D. Baty Amy P. Schmidt Amanda F. Cashen Eric J. Duncavage Nichole M. Helton Mark Fiala Robert S. Fulton Sharon E. Heath Megan Janke Kierstin Luber Peter Westervelt Ravi Vij John F. DiPersio John S. Welch Timothy A. Graubert Matthew J. Walter Timothy J. Ley Daniel C. Link |
| author_facet |
Terrence N. Wong Christopher A. Miller Matthew R. M. Jotte Nusayba Bagegni Jack D. Baty Amy P. Schmidt Amanda F. Cashen Eric J. Duncavage Nichole M. Helton Mark Fiala Robert S. Fulton Sharon E. Heath Megan Janke Kierstin Luber Peter Westervelt Ravi Vij John F. DiPersio John S. Welch Timothy A. Graubert Matthew J. Walter Timothy J. Ley Daniel C. Link |
| author_sort |
Terrence N. Wong |
| title |
Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential |
| title_short |
Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential |
| title_full |
Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential |
| title_fullStr |
Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential |
| title_full_unstemmed |
Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential |
| title_sort |
cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/a452ad93f9a248dab38fccf1d7384184 |
| work_keys_str_mv |
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1718383413808857088 |