Alpha-tocopheryl succinate inhibits autophagic survival of prostate cancer cells induced by vitamin K3 and ascorbate to trigger cell death.

Alpha-tocopheryl succinate inhibits autophagic survival of prostate cancer cells induced by vitamin K3 and ascorbate to trigger cell death.

<h4>Background</h4>The redox-silent vitamin E analog α-tocopheryl succinate (α-TOS) was found to synergistically cooperate with vitamin K3 (VK3) plus ascorbic acid (AA) in the induction of cancer cell-selective apoptosis via a caspase-independent pathway. Here we investigated the molecul...

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Autores principales: Marco Tomasetti, Linda Nocchi, Jiri Neuzil, Jacob Goodwin, Maria Nguyen, Lanfeng Dong, Nicola Manzella, Sara Staffolani, Claudio Milanese, Beatrice Garrone, Renata Alleva, Battista Borghi, Lory Santarelli, Roberto Guerrieri
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/a4582d3a4c6c4292a996162359869d53
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