Meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder

Abstract Alcohol Use Disorder (AUD) is associated with reductions in grey matter (GM) volume which can lead to changes in numerous brain functions. The results of previous studies on altered GM in AUD differ considerably in the regions identified. Three meta-analyses carried out between 2014 and 201...

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Autores principales:	Carolin Spindler, Sebastian Trautmann, Nina Alexander, Sonja Bröning, Sarah Bartscher, Markus Stuppe, Markus Muehlhan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a458599c67ec4d958df5004e24c1d7a8
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spelling	oai:doaj.org-article:a458599c67ec4d958df5004e24c1d7a82021-12-02T13:19:29ZMeta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder10.1038/s41598-021-84804-72045-2322https://doaj.org/article/a458599c67ec4d958df5004e24c1d7a82021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84804-7https://doaj.org/toc/2045-2322Abstract Alcohol Use Disorder (AUD) is associated with reductions in grey matter (GM) volume which can lead to changes in numerous brain functions. The results of previous studies on altered GM in AUD differ considerably in the regions identified. Three meta-analyses carried out between 2014 and 2017 yielded different results. The present study includes the considerable amount of newer research and delivers a state-of-the art meta-analysis in line with recently published guidelines. Additionally, we behaviorally characterized affected regions using fMRI metadata and identified related brain networks by determining their meta-analytic connectivity patterns. Twenty-seven studies with 1,045 AUD patients and 1,054 healthy controls were included in the analysis and analyzed by means of Anatomical Likelihood Estimation (ALE). GM alterations were identified in eight clusters covering different parts of the cingulate and medial frontal gyri, paracentral lobes, left post- and precentral gyri, left anterior and right posterior insulae and left superior frontal gyrus. The behavioral characterization associated these regions with specific cognitive, emotional, somatosensory and motor functions. Moreover, the clusters represent nodes within behaviorally relevant brain networks. Our results suggest that GM reduction in AUD could disrupt network communication responsible for the neurocognitive impairments associated with high chronic alcohol consumption.Carolin SpindlerSebastian TrautmannNina AlexanderSonja BröningSarah BartscherMarkus StuppeMarkus MuehlhanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carolin Spindler Sebastian Trautmann Nina Alexander Sonja Bröning Sarah Bartscher Markus Stuppe Markus Muehlhan Meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder
description	Abstract Alcohol Use Disorder (AUD) is associated with reductions in grey matter (GM) volume which can lead to changes in numerous brain functions. The results of previous studies on altered GM in AUD differ considerably in the regions identified. Three meta-analyses carried out between 2014 and 2017 yielded different results. The present study includes the considerable amount of newer research and delivers a state-of-the art meta-analysis in line with recently published guidelines. Additionally, we behaviorally characterized affected regions using fMRI metadata and identified related brain networks by determining their meta-analytic connectivity patterns. Twenty-seven studies with 1,045 AUD patients and 1,054 healthy controls were included in the analysis and analyzed by means of Anatomical Likelihood Estimation (ALE). GM alterations were identified in eight clusters covering different parts of the cingulate and medial frontal gyri, paracentral lobes, left post- and precentral gyri, left anterior and right posterior insulae and left superior frontal gyrus. The behavioral characterization associated these regions with specific cognitive, emotional, somatosensory and motor functions. Moreover, the clusters represent nodes within behaviorally relevant brain networks. Our results suggest that GM reduction in AUD could disrupt network communication responsible for the neurocognitive impairments associated with high chronic alcohol consumption.
format	article
author	Carolin Spindler Sebastian Trautmann Nina Alexander Sonja Bröning Sarah Bartscher Markus Stuppe Markus Muehlhan
author_facet	Carolin Spindler Sebastian Trautmann Nina Alexander Sonja Bröning Sarah Bartscher Markus Stuppe Markus Muehlhan
author_sort	Carolin Spindler
title	Meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder
title_short	Meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder
title_full	Meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder
title_fullStr	Meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder
title_full_unstemmed	Meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder
title_sort	meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a458599c67ec4d958df5004e24c1d7a8
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Meta-analysis of grey matter changes and their behavioral characterization in patients with alcohol use disorder

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