Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma

Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma

Mantle cell lymphoma can be refractory to treatment. Here, the authors used single cell sequencing to study the tumours of patients that were responsive and resistant to treatment and find gains of 17q in resistant tumours, which they attribute to increased expression of Birc5 and validate these fin...

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Autores principales: Shaojun Zhang, Vivian Changying Jiang, Guangchun Han, Dapeng Hao, Junwei Lian, Yang Liu, Rongjia Zhang, Joseph McIntosh, Ruiping Wang, Minghao Dang, Enyu Dai, Yuanxin Wang, David Santos, Maria Badillo, Angela Leeming, Zhihong Chen, Kimberly Hartig, John Bigcal, Jia Zhou, Rashmi Kanagal-Shamanna, Chi Young Ok, Hun Lee, Raphael E. Steiner, Jianhua Zhang, Xingzhi Song, Ranjit Nair, Sairah Ahmed, Alma Rodriquez, Selvi Thirumurthi, Preetesh Jain, Nicolaus Wagner-Bartak, Holly Hill, Krystle Nomie, Christopher Flowers, Andrew Futreal, Linghua Wang, Michael Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/a45b2ff0cfd44fba8e2f75c8c587a4fd
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spelling oai:doaj.org-article:a45b2ff0cfd44fba8e2f75c8c587a4fd2021-12-02T16:51:25ZLongitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma10.1038/s41467-021-22872-z2041-1723https://doaj.org/article/a45b2ff0cfd44fba8e2f75c8c587a4fd2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22872-zhttps://doaj.org/toc/2041-1723Mantle cell lymphoma can be refractory to treatment. Here, the authors used single cell sequencing to study the tumours of patients that were responsive and resistant to treatment and find gains of 17q in resistant tumours, which they attribute to increased expression of Birc5 and validate these findings in mouse models of the disease.Shaojun ZhangVivian Changying JiangGuangchun HanDapeng HaoJunwei LianYang LiuRongjia ZhangJoseph McIntoshRuiping WangMinghao DangEnyu DaiYuanxin WangDavid SantosMaria BadilloAngela LeemingZhihong ChenKimberly HartigJohn BigcalJia ZhouRashmi Kanagal-ShamannaChi Young OkHun LeeRaphael E. SteinerJianhua ZhangXingzhi SongRanjit NairSairah AhmedAlma RodriquezSelvi ThirumurthiPreetesh JainNicolaus Wagner-BartakHolly HillKrystle NomieChristopher FlowersAndrew FutrealLinghua WangMichael WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shaojun Zhang
Vivian Changying Jiang
Guangchun Han
Dapeng Hao
Junwei Lian
Yang Liu
Rongjia Zhang
Joseph McIntosh
Ruiping Wang
Minghao Dang
Enyu Dai
Yuanxin Wang
David Santos
Maria Badillo
Angela Leeming
Zhihong Chen
Kimberly Hartig
John Bigcal
Jia Zhou
Rashmi Kanagal-Shamanna
Chi Young Ok
Hun Lee
Raphael E. Steiner
Jianhua Zhang
Xingzhi Song
Ranjit Nair
Sairah Ahmed
Alma Rodriquez
Selvi Thirumurthi
Preetesh Jain
Nicolaus Wagner-Bartak
Holly Hill
Krystle Nomie
Christopher Flowers
Andrew Futreal
Linghua Wang
Michael Wang
Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma
description Mantle cell lymphoma can be refractory to treatment. Here, the authors used single cell sequencing to study the tumours of patients that were responsive and resistant to treatment and find gains of 17q in resistant tumours, which they attribute to increased expression of Birc5 and validate these findings in mouse models of the disease.
format article
author Shaojun Zhang
Vivian Changying Jiang
Guangchun Han
Dapeng Hao
Junwei Lian
Yang Liu
Rongjia Zhang
Joseph McIntosh
Ruiping Wang
Minghao Dang
Enyu Dai
Yuanxin Wang
David Santos
Maria Badillo
Angela Leeming
Zhihong Chen
Kimberly Hartig
John Bigcal
Jia Zhou
Rashmi Kanagal-Shamanna
Chi Young Ok
Hun Lee
Raphael E. Steiner
Jianhua Zhang
Xingzhi Song
Ranjit Nair
Sairah Ahmed
Alma Rodriquez
Selvi Thirumurthi
Preetesh Jain
Nicolaus Wagner-Bartak
Holly Hill
Krystle Nomie
Christopher Flowers
Andrew Futreal
Linghua Wang
Michael Wang
author_facet Shaojun Zhang
Vivian Changying Jiang
Guangchun Han
Dapeng Hao
Junwei Lian
Yang Liu
Rongjia Zhang
Joseph McIntosh
Ruiping Wang
Minghao Dang
Enyu Dai
Yuanxin Wang
David Santos
Maria Badillo
Angela Leeming
Zhihong Chen
Kimberly Hartig
John Bigcal
Jia Zhou
Rashmi Kanagal-Shamanna
Chi Young Ok
Hun Lee
Raphael E. Steiner
Jianhua Zhang
Xingzhi Song
Ranjit Nair
Sairah Ahmed
Alma Rodriquez
Selvi Thirumurthi
Preetesh Jain
Nicolaus Wagner-Bartak
Holly Hill
Krystle Nomie
Christopher Flowers
Andrew Futreal
Linghua Wang
Michael Wang
author_sort Shaojun Zhang
title Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma
title_short Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma
title_full Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma
title_fullStr Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma
title_full_unstemmed Longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma
title_sort longitudinal single-cell profiling reveals molecular heterogeneity and tumor-immune evolution in refractory mantle cell lymphoma
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/a45b2ff0cfd44fba8e2f75c8c587a4fd
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