Ta-Coated Titanium Surface With Superior Bacteriostasis And Osseointegration

Xiao-Meng Zhang,* Yuan Li,* Ying-Xin Gu, Chu-Nan Zhang, Hong-Chang Lai, Jun-Yu Shi Department of Implant Dentistry, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicin...

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Autores principales:	Zhang XM, Li Y, Gu YX, Zhang CN, Lai HC, Shi JY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	tantalum-coating antibacterial activity atp synthesis ros generation osseointegration Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a45e30c11e23491492720f4752ff07ac
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spelling	oai:doaj.org-article:a45e30c11e23491492720f4752ff07ac2021-12-02T09:32:39ZTa-Coated Titanium Surface With Superior Bacteriostasis And Osseointegration1178-2013https://doaj.org/article/a45e30c11e23491492720f4752ff07ac2019-11-01T00:00:00Zhttps://www.dovepress.com/ta-coated-titanium-surface-with-superior-bacteriostasis-and-osseointeg-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Xiao-Meng Zhang,* Yuan Li,* Ying-Xin Gu, Chu-Nan Zhang, Hong-Chang Lai, Jun-Yu Shi Department of Implant Dentistry, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hong-Chang Lai; Jun-Yu ShiDepartment of Implant Dentistry, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 500 Quxi Road, Shanghai 200011, People’s Republic of ChinaTel +86 21 23271699 (ext. 5298)Fax +86 21 53073068Email lhc9@hotmail.com; sakyamuni_jin@163.comBackground: Although tantalum (Ta)-based coatings have been proven to have good antibacterial activity, the underlying mechanism and in vivo biological performance remain unclear, which are essential for the clinical application of Ta-coated biomaterials as dental implants.Purpose: The main objective of this study is to investigate the antibacterial activity of Ta-modified titanium (Ti) implants against peri-implantitis-related microbes and the potential molecular mechanisms.Methods: Fusobacterium nucleatum and Porphyromonas gingivalis were selected to evaluate the antibacterial activity and potential antibacterial mechanism of Ta modification. The in vivo biocompatibility of Ta-modified implants was also evaluated.Results: The results showed that Ta-modified surface performed excellent antimicrobial activity against Fusobacterium nucleatum and Porphyromonas gingivalis. Micro galvanic might be formed between the incorporated Ta and the Ti base, which could consume the protons and result in decreased ATP synthesis and increased ROS generation. The gene expression of bacterial virulence factors associated with cellular attachment, invasion and viability as the target of ROS was downregulated. Importantly, in vivo biological studies showed that Ta modification significantly promoted the osseointegration of implants by stimulating the expression of bone-forming proteins.Conclusion: This study may provide some insights into clinical applications of Ta-coated Ti implants, especially in possibly infected situations.Keywords: tantalum-coating, antibacterial activity, ATP synthesis, ROS generation, osseointegrationZhang XMLi YGu YXZhang CNLai HCShi JYDove Medical Pressarticletantalum-coatingantibacterial activityatp synthesisros generationosseointegrationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 8693-8706 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	tantalum-coating antibacterial activity atp synthesis ros generation osseointegration Medicine (General) R5-920
spellingShingle	tantalum-coating antibacterial activity atp synthesis ros generation osseointegration Medicine (General) R5-920 Zhang XM Li Y Gu YX Zhang CN Lai HC Shi JY Ta-Coated Titanium Surface With Superior Bacteriostasis And Osseointegration
description	Xiao-Meng Zhang,* Yuan Li,* Ying-Xin Gu, Chu-Nan Zhang, Hong-Chang Lai, Jun-Yu Shi Department of Implant Dentistry, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hong-Chang Lai; Jun-Yu ShiDepartment of Implant Dentistry, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 500 Quxi Road, Shanghai 200011, People’s Republic of ChinaTel +86 21 23271699 (ext. 5298)Fax +86 21 53073068Email lhc9@hotmail.com; sakyamuni_jin@163.comBackground: Although tantalum (Ta)-based coatings have been proven to have good antibacterial activity, the underlying mechanism and in vivo biological performance remain unclear, which are essential for the clinical application of Ta-coated biomaterials as dental implants.Purpose: The main objective of this study is to investigate the antibacterial activity of Ta-modified titanium (Ti) implants against peri-implantitis-related microbes and the potential molecular mechanisms.Methods: Fusobacterium nucleatum and Porphyromonas gingivalis were selected to evaluate the antibacterial activity and potential antibacterial mechanism of Ta modification. The in vivo biocompatibility of Ta-modified implants was also evaluated.Results: The results showed that Ta-modified surface performed excellent antimicrobial activity against Fusobacterium nucleatum and Porphyromonas gingivalis. Micro galvanic might be formed between the incorporated Ta and the Ti base, which could consume the protons and result in decreased ATP synthesis and increased ROS generation. The gene expression of bacterial virulence factors associated with cellular attachment, invasion and viability as the target of ROS was downregulated. Importantly, in vivo biological studies showed that Ta modification significantly promoted the osseointegration of implants by stimulating the expression of bone-forming proteins.Conclusion: This study may provide some insights into clinical applications of Ta-coated Ti implants, especially in possibly infected situations.Keywords: tantalum-coating, antibacterial activity, ATP synthesis, ROS generation, osseointegration
format	article
author	Zhang XM Li Y Gu YX Zhang CN Lai HC Shi JY
author_facet	Zhang XM Li Y Gu YX Zhang CN Lai HC Shi JY
author_sort	Zhang XM
title	Ta-Coated Titanium Surface With Superior Bacteriostasis And Osseointegration
title_short	Ta-Coated Titanium Surface With Superior Bacteriostasis And Osseointegration
title_full	Ta-Coated Titanium Surface With Superior Bacteriostasis And Osseointegration
title_fullStr	Ta-Coated Titanium Surface With Superior Bacteriostasis And Osseointegration
title_full_unstemmed	Ta-Coated Titanium Surface With Superior Bacteriostasis And Osseointegration
title_sort	ta-coated titanium surface with superior bacteriostasis and osseointegration
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/a45e30c11e23491492720f4752ff07ac
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_version_	1718398080302186496

Ta-Coated Titanium Surface With Superior Bacteriostasis And Osseointegration

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