Serine-linked PARP1 auto-modification controls PARP inhibitor response

PARP inhibitors function by trapping PARP1 protein on DNA breaks, which has cytotoxic consequences to cancer cells. Here the authors identify three serine residues within PARP1 as key sites whose efficient HPF1-dependent modification counters PARP1 trapping and contributes to inhibitor tolerance.

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Autores principales:	Evgeniia Prokhorova, Florian Zobel, Rebecca Smith, Siham Zentout, Ian Gibbs-Seymour, Kira Schützenhofer, Alessandra Peters, Joséphine Groslambert, Valentina Zorzini, Thomas Agnew, John Brognard, Michael L. Nielsen, Dragana Ahel, Sébastien Huet, Marcin J. Suskiewicz, Ivan Ahel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a461bc488c0d420bbd8c111fb3a6c0b4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:a461bc488c0d420bbd8c111fb3a6c0b42021-12-02T16:31:58ZSerine-linked PARP1 auto-modification controls PARP inhibitor response10.1038/s41467-021-24361-92041-1723https://doaj.org/article/a461bc488c0d420bbd8c111fb3a6c0b42021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24361-9https://doaj.org/toc/2041-1723PARP inhibitors function by trapping PARP1 protein on DNA breaks, which has cytotoxic consequences to cancer cells. Here the authors identify three serine residues within PARP1 as key sites whose efficient HPF1-dependent modification counters PARP1 trapping and contributes to inhibitor tolerance.Evgeniia ProkhorovaFlorian ZobelRebecca SmithSiham ZentoutIan Gibbs-SeymourKira SchützenhoferAlessandra PetersJoséphine GroslambertValentina ZorziniThomas AgnewJohn BrognardMichael L. NielsenDragana AhelSébastien HuetMarcin J. SuskiewiczIvan AhelNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Evgeniia Prokhorova Florian Zobel Rebecca Smith Siham Zentout Ian Gibbs-Seymour Kira Schützenhofer Alessandra Peters Joséphine Groslambert Valentina Zorzini Thomas Agnew John Brognard Michael L. Nielsen Dragana Ahel Sébastien Huet Marcin J. Suskiewicz Ivan Ahel Serine-linked PARP1 auto-modification controls PARP inhibitor response
description	PARP inhibitors function by trapping PARP1 protein on DNA breaks, which has cytotoxic consequences to cancer cells. Here the authors identify three serine residues within PARP1 as key sites whose efficient HPF1-dependent modification counters PARP1 trapping and contributes to inhibitor tolerance.
format	article
author	Evgeniia Prokhorova Florian Zobel Rebecca Smith Siham Zentout Ian Gibbs-Seymour Kira Schützenhofer Alessandra Peters Joséphine Groslambert Valentina Zorzini Thomas Agnew John Brognard Michael L. Nielsen Dragana Ahel Sébastien Huet Marcin J. Suskiewicz Ivan Ahel
author_facet	Evgeniia Prokhorova Florian Zobel Rebecca Smith Siham Zentout Ian Gibbs-Seymour Kira Schützenhofer Alessandra Peters Joséphine Groslambert Valentina Zorzini Thomas Agnew John Brognard Michael L. Nielsen Dragana Ahel Sébastien Huet Marcin J. Suskiewicz Ivan Ahel
author_sort	Evgeniia Prokhorova
title	Serine-linked PARP1 auto-modification controls PARP inhibitor response
title_short	Serine-linked PARP1 auto-modification controls PARP inhibitor response
title_full	Serine-linked PARP1 auto-modification controls PARP inhibitor response
title_fullStr	Serine-linked PARP1 auto-modification controls PARP inhibitor response
title_full_unstemmed	Serine-linked PARP1 auto-modification controls PARP inhibitor response
title_sort	serine-linked parp1 auto-modification controls parp inhibitor response
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a461bc488c0d420bbd8c111fb3a6c0b4
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Serine-linked PARP1 auto-modification controls PARP inhibitor response

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