CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis

CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis

CXCL4 is an inflammatory chemokine signaling through CXCR3 receptor. Here the authors show a CXCR3-independent function of CXCL4: it forms liquid crystals with DNA, potentiating mammalian and bacterial DNA recognition by TLR9, thereby amplifying interferon-a production in systemic sclerosis.

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Autores principales: Roberto Lande, Ernest Y. Lee, Raffaella Palazzo, Barbara Marinari, Immacolata Pietraforte, Giancarlo Santiago Santos, Yves Mattenberger, Francesca Spadaro, Katia Stefanantoni, Nicoletta Iannace, Aleksandra Maria Dufour, Mario Falchi, Manuela Bianco, Elisabetta Botti, Luca Bianchi, Montserrat Alvarez, Valeria Riccieri, Marie-Elise Truchetet, Gerard C.L. Wong, Carlo Chizzolini, Loredana Frasca
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/a467d41eb1b041d3bfc13521f62a91e8
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spelling oai:doaj.org-article:a467d41eb1b041d3bfc13521f62a91e82021-12-02T15:35:55ZCXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis10.1038/s41467-019-09683-z2041-1723https://doaj.org/article/a467d41eb1b041d3bfc13521f62a91e82019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09683-zhttps://doaj.org/toc/2041-1723CXCL4 is an inflammatory chemokine signaling through CXCR3 receptor. Here the authors show a CXCR3-independent function of CXCL4: it forms liquid crystals with DNA, potentiating mammalian and bacterial DNA recognition by TLR9, thereby amplifying interferon-a production in systemic sclerosis.Roberto LandeErnest Y. LeeRaffaella PalazzoBarbara MarinariImmacolata PietraforteGiancarlo Santiago SantosYves MattenbergerFrancesca SpadaroKatia StefanantoniNicoletta IannaceAleksandra Maria DufourMario FalchiManuela BiancoElisabetta BottiLuca BianchiMontserrat AlvarezValeria RiccieriMarie-Elise TruchetetGerard C.L. WongCarlo ChizzoliniLoredana FrascaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Roberto Lande
Ernest Y. Lee
Raffaella Palazzo
Barbara Marinari
Immacolata Pietraforte
Giancarlo Santiago Santos
Yves Mattenberger
Francesca Spadaro
Katia Stefanantoni
Nicoletta Iannace
Aleksandra Maria Dufour
Mario Falchi
Manuela Bianco
Elisabetta Botti
Luca Bianchi
Montserrat Alvarez
Valeria Riccieri
Marie-Elise Truchetet
Gerard C.L. Wong
Carlo Chizzolini
Loredana Frasca
CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis
description CXCL4 is an inflammatory chemokine signaling through CXCR3 receptor. Here the authors show a CXCR3-independent function of CXCL4: it forms liquid crystals with DNA, potentiating mammalian and bacterial DNA recognition by TLR9, thereby amplifying interferon-a production in systemic sclerosis.
format article
author Roberto Lande
Ernest Y. Lee
Raffaella Palazzo
Barbara Marinari
Immacolata Pietraforte
Giancarlo Santiago Santos
Yves Mattenberger
Francesca Spadaro
Katia Stefanantoni
Nicoletta Iannace
Aleksandra Maria Dufour
Mario Falchi
Manuela Bianco
Elisabetta Botti
Luca Bianchi
Montserrat Alvarez
Valeria Riccieri
Marie-Elise Truchetet
Gerard C.L. Wong
Carlo Chizzolini
Loredana Frasca
author_facet Roberto Lande
Ernest Y. Lee
Raffaella Palazzo
Barbara Marinari
Immacolata Pietraforte
Giancarlo Santiago Santos
Yves Mattenberger
Francesca Spadaro
Katia Stefanantoni
Nicoletta Iannace
Aleksandra Maria Dufour
Mario Falchi
Manuela Bianco
Elisabetta Botti
Luca Bianchi
Montserrat Alvarez
Valeria Riccieri
Marie-Elise Truchetet
Gerard C.L. Wong
Carlo Chizzolini
Loredana Frasca
author_sort Roberto Lande
title CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis
title_short CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis
title_full CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis
title_fullStr CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis
title_full_unstemmed CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis
title_sort cxcl4 assembles dna into liquid crystalline complexes to amplify tlr9-mediated interferon-α production in systemic sclerosis
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/a467d41eb1b041d3bfc13521f62a91e8
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