Thyroid function and ischemic heart disease: a Mendelian randomization study

Abstract To clarify the role of thyroid function in ischemic heart disease (IHD) we assessed IHD risk and risk factors according to genetically predicted thyroid stimulating hormone (TSH), free thyroxine (FT4) and thyroid peroxidase antibody (TPOAb) positivity. Separate-sample instrumental variable...

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Autores principales:	Jie V. Zhao, C. Mary Schooling
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a468ac6ff33f4f0eb3605740e8085d8c
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spelling	oai:doaj.org-article:a468ac6ff33f4f0eb3605740e8085d8c2021-12-02T12:32:26ZThyroid function and ischemic heart disease: a Mendelian randomization study10.1038/s41598-017-07592-z2045-2322https://doaj.org/article/a468ac6ff33f4f0eb3605740e8085d8c2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07592-zhttps://doaj.org/toc/2045-2322Abstract To clarify the role of thyroid function in ischemic heart disease (IHD) we assessed IHD risk and risk factors according to genetically predicted thyroid stimulating hormone (TSH), free thyroxine (FT4) and thyroid peroxidase antibody (TPOAb) positivity. Separate-sample instrumental variable analysis with genetic instruments (Mendelian randomization) was used in an extensively genotyped case (n = 64,374)-control (n = 130,681) study, CARDIoGRAMplusC4D. Associations with lipids, diabetes and adiposity were assessed using the Global Lipids Genetics Consortium Results (n = 196,475), the DIAbetes Genetics Replication And Meta-analysis case (n = 34,380)-control (n = 114,981) study, and the Genetic Investigation of ANthropometric Traits (body mass index in 152,893 men and 171,977 women, waist-hip ratio in 93,480 men and 116,741 women). Genetically predicted thyroid function was not associated with IHD (odds ratio (OR) per standard deviation for TSH 1.05, 95% confidence interval (CI) 0.97 to 1.12; for FT4 1.01, 95% CI 0.91 to 1.12; for TPOAb positivity 1.10, 95% CI 0.83 to 1.46) or after Bonferroni correction with risk factors, except for an inverse association of FT4 with low-density lipoprotein-cholesterol. The associations were generally robust to sensitivity analyses using a weighted median method and MR Egger. This novel study provides little indication that TSH, FT4 or TPOAb positivity affects IHD, despite potential effects on its risk factors.Jie V. ZhaoC. Mary SchoolingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jie V. Zhao C. Mary Schooling Thyroid function and ischemic heart disease: a Mendelian randomization study
description	Abstract To clarify the role of thyroid function in ischemic heart disease (IHD) we assessed IHD risk and risk factors according to genetically predicted thyroid stimulating hormone (TSH), free thyroxine (FT4) and thyroid peroxidase antibody (TPOAb) positivity. Separate-sample instrumental variable analysis with genetic instruments (Mendelian randomization) was used in an extensively genotyped case (n = 64,374)-control (n = 130,681) study, CARDIoGRAMplusC4D. Associations with lipids, diabetes and adiposity were assessed using the Global Lipids Genetics Consortium Results (n = 196,475), the DIAbetes Genetics Replication And Meta-analysis case (n = 34,380)-control (n = 114,981) study, and the Genetic Investigation of ANthropometric Traits (body mass index in 152,893 men and 171,977 women, waist-hip ratio in 93,480 men and 116,741 women). Genetically predicted thyroid function was not associated with IHD (odds ratio (OR) per standard deviation for TSH 1.05, 95% confidence interval (CI) 0.97 to 1.12; for FT4 1.01, 95% CI 0.91 to 1.12; for TPOAb positivity 1.10, 95% CI 0.83 to 1.46) or after Bonferroni correction with risk factors, except for an inverse association of FT4 with low-density lipoprotein-cholesterol. The associations were generally robust to sensitivity analyses using a weighted median method and MR Egger. This novel study provides little indication that TSH, FT4 or TPOAb positivity affects IHD, despite potential effects on its risk factors.
format	article
author	Jie V. Zhao C. Mary Schooling
author_facet	Jie V. Zhao C. Mary Schooling
author_sort	Jie V. Zhao
title	Thyroid function and ischemic heart disease: a Mendelian randomization study
title_short	Thyroid function and ischemic heart disease: a Mendelian randomization study
title_full	Thyroid function and ischemic heart disease: a Mendelian randomization study
title_fullStr	Thyroid function and ischemic heart disease: a Mendelian randomization study
title_full_unstemmed	Thyroid function and ischemic heart disease: a Mendelian randomization study
title_sort	thyroid function and ischemic heart disease: a mendelian randomization study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a468ac6ff33f4f0eb3605740e8085d8c
work_keys_str_mv	AT jievzhao thyroidfunctionandischemicheartdiseaseamendelianrandomizationstudy AT cmaryschooling thyroidfunctionandischemicheartdiseaseamendelianrandomizationstudy
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Thyroid function and ischemic heart disease: a Mendelian randomization study

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