Environmentally Endemic <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content> Strains with Mutations in <italic toggle="yes">lasR</italic> Are Associated with Increased Disease Severity in Corneal Ulcers

Environmentally Endemic <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content> Strains with Mutations in <italic toggle="yes">lasR</italic> Are Associated with Increased Disease Severity in Corneal Ulcers

ABSTRACT The Steroids for Corneal Ulcers Trial (SCUT) was a multicenter, international study of bacterial keratitis in which 101 Pseudomonas aeruginosa infections were treated. Twenty-two of 101 P. aeruginosa isolates collected had a colony morphology characteristic of a loss-of-function mutation in...

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Bibliographic Details
Main Authors: John H. Hammond, Wesley P. Hebert, Amanda Naimie, Kathryn Ray, Rachel D. Van Gelder, Antonio DiGiandomenico, Prajna Lalitha, Muthiah Srinivasan, Nisha R. Acharya, Thomas Lietman, Deborah A. Hogan, Michael E. Zegans
Format: article
Language:EN
Published: American Society for Microbiology 2016
Subjects:
Anr
bacterial keratitis
corneal ulcer
CupA
eye infection
LasR
Microbiology
QR1-502
Online Access:https://doaj.org/article/a468f1dcf82c4c53beb31271c81f3647
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