Characteristics of the microbiocenosis of the vaginal tract and its role in initiating inflammatory process in endometrium in women with reproductive disorders

Background. Microbiological disorders in the genital tract predispose to the development of chronic pelvic diseases and subsequently worsen the prognosis for reproductive function, causing infertility, miscarriage. Aims: study of the microbiocenosis of the vaginal tract and its role in initiating in...

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Autores principales:	I. N. Danusevich, E. I. Ivanova, I. M. Mikhalevich
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	chronic endometritis immunity reproductive disorders microbiocenosis of the genital tract Science Q
Acceso en línea:	https://doaj.org/article/a46b9fad6fc046fa985954784f07ea29
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spelling	oai:doaj.org-article:a46b9fad6fc046fa985954784f07ea292021-11-23T06:14:38ZCharacteristics of the microbiocenosis of the vaginal tract and its role in initiating inflammatory process in endometrium in women with reproductive disorders2541-94202587-959610.12737/article_5a3a0d6243ea24.16475434https://doaj.org/article/a46b9fad6fc046fa985954784f07ea292017-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/500https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. Microbiological disorders in the genital tract predispose to the development of chronic pelvic diseases and subsequently worsen the prognosis for reproductive function, causing infertility, miscarriage. Aims: study of the microbiocenosis of the vaginal tract and its role in initiating inflammatory process in endometrium in women with reproductive disorders. Materials and methods. The study included 50 patients with reproductive disorders with histological confirmation of the diagnosis of chronic endometritis and 50 patients with reproductive disorders without chronic endometritis. Microbiological studies of the biotope of the vagina were carried out according to the guidelines. The counting of immune cells was carried out in peripheral blood with flow cytofluorimeter. Methods of mathematical statistics implemented in the application package Statistica 6.1 (StatSoft Inc., USA) were used in the study. Used criteria were Student's t-test and Fisher criterion with a significance level less than 5 % (p < 0.05). Results and conclusions. Conditionally pathogenic microflora in women with chronic endometritis in the cervical canal is represented by candidiasis, herpesviruses, ureaplasma and facultative-anaerobically positive microorganisms. Candida, obligate-anaerobic gram-negative, and facultative anaerobic gram-positive microorganisms predominated in the endometrium. The secondary immunodeficiency state is characterized by suppressor activity of T-lymphocytes; the decrease in microbicide activity of blood, pronounced inhibition of the humoral link of the immune system. Violations of the balance of the indigenous and conditionally pathogenic microflora accompanied by a secondary immunodeficiency may be the initiator of chronic inflammation in the endometrium.I. N. DanusevichE. I. IvanovaI. M. MikhalevichScientific Сentre for Family Health and Human Reproduction Problemsarticlechronic endometritisimmunityreproductive disordersmicrobiocenosis of the genital tractScienceQRUActa Biomedica Scientifica, Vol 2, Iss 5(2), Pp 15-20 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic endometritis immunity reproductive disorders microbiocenosis of the genital tract Science Q
spellingShingle	chronic endometritis immunity reproductive disorders microbiocenosis of the genital tract Science Q I. N. Danusevich E. I. Ivanova I. M. Mikhalevich Characteristics of the microbiocenosis of the vaginal tract and its role in initiating inflammatory process in endometrium in women with reproductive disorders
description	Background. Microbiological disorders in the genital tract predispose to the development of chronic pelvic diseases and subsequently worsen the prognosis for reproductive function, causing infertility, miscarriage. Aims: study of the microbiocenosis of the vaginal tract and its role in initiating inflammatory process in endometrium in women with reproductive disorders. Materials and methods. The study included 50 patients with reproductive disorders with histological confirmation of the diagnosis of chronic endometritis and 50 patients with reproductive disorders without chronic endometritis. Microbiological studies of the biotope of the vagina were carried out according to the guidelines. The counting of immune cells was carried out in peripheral blood with flow cytofluorimeter. Methods of mathematical statistics implemented in the application package Statistica 6.1 (StatSoft Inc., USA) were used in the study. Used criteria were Student's t-test and Fisher criterion with a significance level less than 5 % (p < 0.05). Results and conclusions. Conditionally pathogenic microflora in women with chronic endometritis in the cervical canal is represented by candidiasis, herpesviruses, ureaplasma and facultative-anaerobically positive microorganisms. Candida, obligate-anaerobic gram-negative, and facultative anaerobic gram-positive microorganisms predominated in the endometrium. The secondary immunodeficiency state is characterized by suppressor activity of T-lymphocytes; the decrease in microbicide activity of blood, pronounced inhibition of the humoral link of the immune system. Violations of the balance of the indigenous and conditionally pathogenic microflora accompanied by a secondary immunodeficiency may be the initiator of chronic inflammation in the endometrium.
format	article
author	I. N. Danusevich E. I. Ivanova I. M. Mikhalevich
author_facet	I. N. Danusevich E. I. Ivanova I. M. Mikhalevich
author_sort	I. N. Danusevich
title	Characteristics of the microbiocenosis of the vaginal tract and its role in initiating inflammatory process in endometrium in women with reproductive disorders
title_short	Characteristics of the microbiocenosis of the vaginal tract and its role in initiating inflammatory process in endometrium in women with reproductive disorders
title_full	Characteristics of the microbiocenosis of the vaginal tract and its role in initiating inflammatory process in endometrium in women with reproductive disorders
title_fullStr	Characteristics of the microbiocenosis of the vaginal tract and its role in initiating inflammatory process in endometrium in women with reproductive disorders
title_full_unstemmed	Characteristics of the microbiocenosis of the vaginal tract and its role in initiating inflammatory process in endometrium in women with reproductive disorders
title_sort	characteristics of the microbiocenosis of the vaginal tract and its role in initiating inflammatory process in endometrium in women with reproductive disorders
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/a46b9fad6fc046fa985954784f07ea29
work_keys_str_mv	AT indanusevich characteristicsofthemicrobiocenosisofthevaginaltractanditsroleininitiatinginflammatoryprocessinendometriuminwomenwithreproductivedisorders AT eiivanova characteristicsofthemicrobiocenosisofthevaginaltractanditsroleininitiatinginflammatoryprocessinendometriuminwomenwithreproductivedisorders AT immikhalevich characteristicsofthemicrobiocenosisofthevaginaltractanditsroleininitiatinginflammatoryprocessinendometriuminwomenwithreproductivedisorders
_version_	1718417025107230720

Characteristics of the microbiocenosis of the vaginal tract and its role in initiating inflammatory process in endometrium in women with reproductive disorders

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