Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure

The outer mitochondrial membrane translocator protein (TSPO) mediates several mitochondrial functions and binds cholesterol with a high affinity. Here the authors use solid-state NMR to show that cholesterol binding to TSPO results in allosteric changes that modulate TSPO oligomerization.

Guardado en:

Detalles Bibliográficos
Autores principales:	Garima Jaipuria, Andrei Leonov, Karin Giller, Suresh Kumar Vasa, Łukasz Jaremko, Mariusz Jaremko, Rasmus Linser, Stefan Becker, Markus Zweckstetter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a46da088e92c420c87ebaa77aef97943
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a46da088e92c420c87ebaa77aef97943
record_format	dspace
spelling	oai:doaj.org-article:a46da088e92c420c87ebaa77aef979432021-12-02T15:37:04ZCholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure10.1038/ncomms148932041-1723https://doaj.org/article/a46da088e92c420c87ebaa77aef979432017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14893https://doaj.org/toc/2041-1723The outer mitochondrial membrane translocator protein (TSPO) mediates several mitochondrial functions and binds cholesterol with a high affinity. Here the authors use solid-state NMR to show that cholesterol binding to TSPO results in allosteric changes that modulate TSPO oligomerization.Garima JaipuriaAndrei LeonovKarin GillerSuresh Kumar VasaŁukasz JaremkoMariusz JaremkoRasmus LinserStefan BeckerMarkus ZweckstetterNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Garima Jaipuria Andrei Leonov Karin Giller Suresh Kumar Vasa Łukasz Jaremko Mariusz Jaremko Rasmus Linser Stefan Becker Markus Zweckstetter Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure
description	The outer mitochondrial membrane translocator protein (TSPO) mediates several mitochondrial functions and binds cholesterol with a high affinity. Here the authors use solid-state NMR to show that cholesterol binding to TSPO results in allosteric changes that modulate TSPO oligomerization.
format	article
author	Garima Jaipuria Andrei Leonov Karin Giller Suresh Kumar Vasa Łukasz Jaremko Mariusz Jaremko Rasmus Linser Stefan Becker Markus Zweckstetter
author_facet	Garima Jaipuria Andrei Leonov Karin Giller Suresh Kumar Vasa Łukasz Jaremko Mariusz Jaremko Rasmus Linser Stefan Becker Markus Zweckstetter
author_sort	Garima Jaipuria
title	Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure
title_short	Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure
title_full	Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure
title_fullStr	Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure
title_full_unstemmed	Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure
title_sort	cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a46da088e92c420c87ebaa77aef97943
work_keys_str_mv	AT garimajaipuria cholesterolmediatedallostericregulationofthemitochondrialtranslocatorproteinstructure AT andreileonov cholesterolmediatedallostericregulationofthemitochondrialtranslocatorproteinstructure AT karingiller cholesterolmediatedallostericregulationofthemitochondrialtranslocatorproteinstructure AT sureshkumarvasa cholesterolmediatedallostericregulationofthemitochondrialtranslocatorproteinstructure AT łukaszjaremko cholesterolmediatedallostericregulationofthemitochondrialtranslocatorproteinstructure AT mariuszjaremko cholesterolmediatedallostericregulationofthemitochondrialtranslocatorproteinstructure AT rasmuslinser cholesterolmediatedallostericregulationofthemitochondrialtranslocatorproteinstructure AT stefanbecker cholesterolmediatedallostericregulationofthemitochondrialtranslocatorproteinstructure AT markuszweckstetter cholesterolmediatedallostericregulationofthemitochondrialtranslocatorproteinstructure
_version_	1718386250196451328

Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure

Ejemplares similares