Peptidomimetic blockade of MYB in acute myeloid leukemia

MYB activity is a key factor for the maintenance of acute myeloid leukemias but it is also a difficult target. Here, the authors develop a peptidomimetic (MYBMIM) that prevents the interaction of the trans-activation domain of MYB with the KIX domain of CBP/P300 and inhibits leukaemia growth.

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Autores principales:	Kavitha Ramaswamy, Lauren Forbes, Gerard Minuesa, Tatyana Gindin, Fiona Brown, Michael G. Kharas, Andrei V. Krivtsov, Scott A. Armstrong, Eric Still, Elisa de Stanchina, Birgit Knoechel, Richard Koche, Alex Kentsis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a470abd9ea4643cfb47136bbe875cfb7
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spelling	oai:doaj.org-article:a470abd9ea4643cfb47136bbe875cfb72021-12-02T17:33:04ZPeptidomimetic blockade of MYB in acute myeloid leukemia10.1038/s41467-017-02618-62041-1723https://doaj.org/article/a470abd9ea4643cfb47136bbe875cfb72018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02618-6https://doaj.org/toc/2041-1723MYB activity is a key factor for the maintenance of acute myeloid leukemias but it is also a difficult target. Here, the authors develop a peptidomimetic (MYBMIM) that prevents the interaction of the trans-activation domain of MYB with the KIX domain of CBP/P300 and inhibits leukaemia growth.Kavitha RamaswamyLauren ForbesGerard MinuesaTatyana GindinFiona BrownMichael G. KharasAndrei V. KrivtsovScott A. ArmstrongEric StillElisa de StanchinaBirgit KnoechelRichard KocheAlex KentsisNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kavitha Ramaswamy Lauren Forbes Gerard Minuesa Tatyana Gindin Fiona Brown Michael G. Kharas Andrei V. Krivtsov Scott A. Armstrong Eric Still Elisa de Stanchina Birgit Knoechel Richard Koche Alex Kentsis Peptidomimetic blockade of MYB in acute myeloid leukemia
description	MYB activity is a key factor for the maintenance of acute myeloid leukemias but it is also a difficult target. Here, the authors develop a peptidomimetic (MYBMIM) that prevents the interaction of the trans-activation domain of MYB with the KIX domain of CBP/P300 and inhibits leukaemia growth.
format	article
author	Kavitha Ramaswamy Lauren Forbes Gerard Minuesa Tatyana Gindin Fiona Brown Michael G. Kharas Andrei V. Krivtsov Scott A. Armstrong Eric Still Elisa de Stanchina Birgit Knoechel Richard Koche Alex Kentsis
author_facet	Kavitha Ramaswamy Lauren Forbes Gerard Minuesa Tatyana Gindin Fiona Brown Michael G. Kharas Andrei V. Krivtsov Scott A. Armstrong Eric Still Elisa de Stanchina Birgit Knoechel Richard Koche Alex Kentsis
author_sort	Kavitha Ramaswamy
title	Peptidomimetic blockade of MYB in acute myeloid leukemia
title_short	Peptidomimetic blockade of MYB in acute myeloid leukemia
title_full	Peptidomimetic blockade of MYB in acute myeloid leukemia
title_fullStr	Peptidomimetic blockade of MYB in acute myeloid leukemia
title_full_unstemmed	Peptidomimetic blockade of MYB in acute myeloid leukemia
title_sort	peptidomimetic blockade of myb in acute myeloid leukemia
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a470abd9ea4643cfb47136bbe875cfb7
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Peptidomimetic blockade of MYB in acute myeloid leukemia

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