Management of Invasive Infections due to a Rare Arthroconidial Yeast, <i>Saprochaete capitata</i>, in Two Patients with Acute Hematological Malignancies

<i>Saprochaete capitata</i> is an arthroconidial yeast, found principally in the environment, even if it belongs also to the normal microbial flora that colonize human subjects. This yeast is increasingly associated with invasive infections in hematological patients, in particular in tho...

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Autores principales:	Francesca Gurrieri, Silvia Corbellini, Giorgio Piccinelli, Alessandro Turra, Enrico Morello, Michele Malagola, Domenico Russo, Arnaldo Caruso, Maria Antonia De Francesco
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	immunosuppression fungal infection neutropenia bone marrow transplantation Medicine R
Acceso en línea:	https://doaj.org/article/a4736dc4259944368711b7e55cdf010b
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spelling	oai:doaj.org-article:a4736dc4259944368711b7e55cdf010b2021-11-25T19:10:58ZManagement of Invasive Infections due to a Rare Arthroconidial Yeast, <i>Saprochaete capitata</i>, in Two Patients with Acute Hematological Malignancies10.3390/vaccines91112892076-393Xhttps://doaj.org/article/a4736dc4259944368711b7e55cdf010b2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-393X/9/11/1289https://doaj.org/toc/2076-393X<i>Saprochaete capitata</i> is an arthroconidial yeast, found principally in the environment, even if it belongs also to the normal microbial flora that colonize human subjects. This yeast is increasingly associated with invasive infections in hematological patients, in particular in those affected by acute leukemia. An important risk factor that predisposes to this infection is the profound neutropenia present in such immunocompromised patients. <i>Saprochaete</i> spp. were found resistant to both echinocandins and fluconazole so the treatment is often difficult. Here, we report two cases of sepsis in two patients with acute leukemia. All of them had fatal events, due to the worsening of their clinical condition. An early diagnosis and appropriate management of these pathogens is important in consideration of the poor prognosis associated to these fungal invasive infections.Francesca GurrieriSilvia CorbelliniGiorgio PiccinelliAlessandro TurraEnrico MorelloMichele MalagolaDomenico RussoArnaldo CarusoMaria Antonia De FrancescoMDPI AGarticleimmunosuppressionfungal infectionneutropeniabone marrow transplantationMedicineRENVaccines, Vol 9, Iss 1289, p 1289 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	immunosuppression fungal infection neutropenia bone marrow transplantation Medicine R
spellingShingle	immunosuppression fungal infection neutropenia bone marrow transplantation Medicine R Francesca Gurrieri Silvia Corbellini Giorgio Piccinelli Alessandro Turra Enrico Morello Michele Malagola Domenico Russo Arnaldo Caruso Maria Antonia De Francesco Management of Invasive Infections due to a Rare Arthroconidial Yeast, <i>Saprochaete capitata</i>, in Two Patients with Acute Hematological Malignancies
description	<i>Saprochaete capitata</i> is an arthroconidial yeast, found principally in the environment, even if it belongs also to the normal microbial flora that colonize human subjects. This yeast is increasingly associated with invasive infections in hematological patients, in particular in those affected by acute leukemia. An important risk factor that predisposes to this infection is the profound neutropenia present in such immunocompromised patients. <i>Saprochaete</i> spp. were found resistant to both echinocandins and fluconazole so the treatment is often difficult. Here, we report two cases of sepsis in two patients with acute leukemia. All of them had fatal events, due to the worsening of their clinical condition. An early diagnosis and appropriate management of these pathogens is important in consideration of the poor prognosis associated to these fungal invasive infections.
format	article
author	Francesca Gurrieri Silvia Corbellini Giorgio Piccinelli Alessandro Turra Enrico Morello Michele Malagola Domenico Russo Arnaldo Caruso Maria Antonia De Francesco
author_facet	Francesca Gurrieri Silvia Corbellini Giorgio Piccinelli Alessandro Turra Enrico Morello Michele Malagola Domenico Russo Arnaldo Caruso Maria Antonia De Francesco
author_sort	Francesca Gurrieri
title	Management of Invasive Infections due to a Rare Arthroconidial Yeast, <i>Saprochaete capitata</i>, in Two Patients with Acute Hematological Malignancies
title_short	Management of Invasive Infections due to a Rare Arthroconidial Yeast, <i>Saprochaete capitata</i>, in Two Patients with Acute Hematological Malignancies
title_full	Management of Invasive Infections due to a Rare Arthroconidial Yeast, <i>Saprochaete capitata</i>, in Two Patients with Acute Hematological Malignancies
title_fullStr	Management of Invasive Infections due to a Rare Arthroconidial Yeast, <i>Saprochaete capitata</i>, in Two Patients with Acute Hematological Malignancies
title_full_unstemmed	Management of Invasive Infections due to a Rare Arthroconidial Yeast, <i>Saprochaete capitata</i>, in Two Patients with Acute Hematological Malignancies
title_sort	management of invasive infections due to a rare arthroconidial yeast, <i>saprochaete capitata</i>, in two patients with acute hematological malignancies
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a4736dc4259944368711b7e55cdf010b
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Management of Invasive Infections due to a Rare Arthroconidial Yeast, <i>Saprochaete capitata</i>, in Two Patients with Acute Hematological Malignancies

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