Biological Activity Evaluation and In Silico Studies of Polyprenylated Benzophenones from <i>Garcinia celebica</i>
This study aimed to isolate polyprenylated benzophenones from the rootbark of <i>Garcinia celebica</i> and assess their activities in vitro and in silico. The antioxidant activity was evaluated by the DPPH, ABTS, and FRAP methods. The cytotoxicity was evaluated against HeLa, MCF-7, A549,...
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| Autores principales: | , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/a474294a34d042f2825412222f6d652b |
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| Sumario: | This study aimed to isolate polyprenylated benzophenones from the rootbark of <i>Garcinia celebica</i> and assess their activities in vitro and in silico. The antioxidant activity was evaluated by the DPPH, ABTS, and FRAP methods. The cytotoxicity was evaluated against HeLa, MCF-7, A549, and B16 cancer cell lines. The antiplasmodial activity was performed against the chloroquine-sensitive <i>Plasmodium falciparum</i> strain 3D7. Molecular docking was analyzed on alpha-estrogen receptor (3ERT) and <i>P. falciparum</i> lactate dehydrogenase enzyme (1CET). The prediction of ADMET for the compounds was also studied. For the first time, (-)-cycloxanthochymol, isoxanthochymol, and xanthochymol were isolated from the root bark of <i>Garcinia celebica</i>. The antioxidant and cytotoxicity evaluation showed that all benzophenones exhibited antioxidant activity compared to gallic acid and quercetin as positive controls and also exhibited strong activity against HeLa, MCF-7, A549, and B16 cell lines compared to cisplatin as the positive control. The antiplasmodial evaluation showed that isoxanthochymol exhibited activity against the chloroquine-sensitive <i>P. falciparum</i> strain 3D7. In addition, the in silico molecular docking study supported in vitro activities. The ADMET analysis also indicated the isolated benzophenones are potential oral drug candidates. |
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