Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids

Human pluripotent stem cell-derived intestinal organoids (hIOs) are a useful model with which to study intestinal development and disease, but they require in vivo maturation to resemble adult tissue. Here, the authors show that T lymphocyte-derived IL-2 induces hIO maturation in vitro through the a...

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Autores principales:	Kwang Bo Jung, Hana Lee, Ye Seul Son, Mi-Ok Lee, Young-Dae Kim, Soo Jin Oh, Ohman Kwon, Sunwha Cho, Hyun-Soo Cho, Dae-Soo Kim, Jung-Hwa Oh, Matthias Zilbauer, Jeong-Ki Min, Cho-Rok Jung, Janghwan Kim, Mi-Young Son
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a475745ef0d7496ba465e8488bf0de6b
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spelling	oai:doaj.org-article:a475745ef0d7496ba465e8488bf0de6b2021-12-02T15:34:43ZInterleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids10.1038/s41467-018-05450-82041-1723https://doaj.org/article/a475745ef0d7496ba465e8488bf0de6b2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05450-8https://doaj.org/toc/2041-1723Human pluripotent stem cell-derived intestinal organoids (hIOs) are a useful model with which to study intestinal development and disease, but they require in vivo maturation to resemble adult tissue. Here, the authors show that T lymphocyte-derived IL-2 induces hIO maturation in vitro through the activation of STAT3.Kwang Bo JungHana LeeYe Seul SonMi-Ok LeeYoung-Dae KimSoo Jin OhOhman KwonSunwha ChoHyun-Soo ChoDae-Soo KimJung-Hwa OhMatthias ZilbauerJeong-Ki MinCho-Rok JungJanghwan KimMi-Young SonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kwang Bo Jung Hana Lee Ye Seul Son Mi-Ok Lee Young-Dae Kim Soo Jin Oh Ohman Kwon Sunwha Cho Hyun-Soo Cho Dae-Soo Kim Jung-Hwa Oh Matthias Zilbauer Jeong-Ki Min Cho-Rok Jung Janghwan Kim Mi-Young Son Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids
description	Human pluripotent stem cell-derived intestinal organoids (hIOs) are a useful model with which to study intestinal development and disease, but they require in vivo maturation to resemble adult tissue. Here, the authors show that T lymphocyte-derived IL-2 induces hIO maturation in vitro through the activation of STAT3.
format	article
author	Kwang Bo Jung Hana Lee Ye Seul Son Mi-Ok Lee Young-Dae Kim Soo Jin Oh Ohman Kwon Sunwha Cho Hyun-Soo Cho Dae-Soo Kim Jung-Hwa Oh Matthias Zilbauer Jeong-Ki Min Cho-Rok Jung Janghwan Kim Mi-Young Son
author_facet	Kwang Bo Jung Hana Lee Ye Seul Son Mi-Ok Lee Young-Dae Kim Soo Jin Oh Ohman Kwon Sunwha Cho Hyun-Soo Cho Dae-Soo Kim Jung-Hwa Oh Matthias Zilbauer Jeong-Ki Min Cho-Rok Jung Janghwan Kim Mi-Young Son
author_sort	Kwang Bo Jung
title	Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids
title_short	Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids
title_full	Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids
title_fullStr	Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids
title_full_unstemmed	Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids
title_sort	interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a475745ef0d7496ba465e8488bf0de6b
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Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids

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