Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids

Human pluripotent stem cell-derived intestinal organoids (hIOs) are a useful model with which to study intestinal development and disease, but they require in vivo maturation to resemble adult tissue. Here, the authors show that T lymphocyte-derived IL-2 induces hIO maturation in vitro through the a...

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Autores principales: Kwang Bo Jung, Hana Lee, Ye Seul Son, Mi-Ok Lee, Young-Dae Kim, Soo Jin Oh, Ohman Kwon, Sunwha Cho, Hyun-Soo Cho, Dae-Soo Kim, Jung-Hwa Oh, Matthias Zilbauer, Jeong-Ki Min, Cho-Rok Jung, Janghwan Kim, Mi-Young Son
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/a475745ef0d7496ba465e8488bf0de6b
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spelling oai:doaj.org-article:a475745ef0d7496ba465e8488bf0de6b2021-12-02T15:34:43ZInterleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids10.1038/s41467-018-05450-82041-1723https://doaj.org/article/a475745ef0d7496ba465e8488bf0de6b2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05450-8https://doaj.org/toc/2041-1723Human pluripotent stem cell-derived intestinal organoids (hIOs) are a useful model with which to study intestinal development and disease, but they require in vivo maturation to resemble adult tissue. Here, the authors show that T lymphocyte-derived IL-2 induces hIO maturation in vitro through the activation of STAT3.Kwang Bo JungHana LeeYe Seul SonMi-Ok LeeYoung-Dae KimSoo Jin OhOhman KwonSunwha ChoHyun-Soo ChoDae-Soo KimJung-Hwa OhMatthias ZilbauerJeong-Ki MinCho-Rok JungJanghwan KimMi-Young SonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kwang Bo Jung
Hana Lee
Ye Seul Son
Mi-Ok Lee
Young-Dae Kim
Soo Jin Oh
Ohman Kwon
Sunwha Cho
Hyun-Soo Cho
Dae-Soo Kim
Jung-Hwa Oh
Matthias Zilbauer
Jeong-Ki Min
Cho-Rok Jung
Janghwan Kim
Mi-Young Son
Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids
description Human pluripotent stem cell-derived intestinal organoids (hIOs) are a useful model with which to study intestinal development and disease, but they require in vivo maturation to resemble adult tissue. Here, the authors show that T lymphocyte-derived IL-2 induces hIO maturation in vitro through the activation of STAT3.
format article
author Kwang Bo Jung
Hana Lee
Ye Seul Son
Mi-Ok Lee
Young-Dae Kim
Soo Jin Oh
Ohman Kwon
Sunwha Cho
Hyun-Soo Cho
Dae-Soo Kim
Jung-Hwa Oh
Matthias Zilbauer
Jeong-Ki Min
Cho-Rok Jung
Janghwan Kim
Mi-Young Son
author_facet Kwang Bo Jung
Hana Lee
Ye Seul Son
Mi-Ok Lee
Young-Dae Kim
Soo Jin Oh
Ohman Kwon
Sunwha Cho
Hyun-Soo Cho
Dae-Soo Kim
Jung-Hwa Oh
Matthias Zilbauer
Jeong-Ki Min
Cho-Rok Jung
Janghwan Kim
Mi-Young Son
author_sort Kwang Bo Jung
title Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids
title_short Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids
title_full Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids
title_fullStr Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids
title_full_unstemmed Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids
title_sort interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/a475745ef0d7496ba465e8488bf0de6b
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