Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids
Human pluripotent stem cell-derived intestinal organoids (hIOs) are a useful model with which to study intestinal development and disease, but they require in vivo maturation to resemble adult tissue. Here, the authors show that T lymphocyte-derived IL-2 induces hIO maturation in vitro through the a...
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Nature Portfolio
2018
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oai:doaj.org-article:a475745ef0d7496ba465e8488bf0de6b2021-12-02T15:34:43ZInterleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids10.1038/s41467-018-05450-82041-1723https://doaj.org/article/a475745ef0d7496ba465e8488bf0de6b2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05450-8https://doaj.org/toc/2041-1723Human pluripotent stem cell-derived intestinal organoids (hIOs) are a useful model with which to study intestinal development and disease, but they require in vivo maturation to resemble adult tissue. Here, the authors show that T lymphocyte-derived IL-2 induces hIO maturation in vitro through the activation of STAT3.Kwang Bo JungHana LeeYe Seul SonMi-Ok LeeYoung-Dae KimSoo Jin OhOhman KwonSunwha ChoHyun-Soo ChoDae-Soo KimJung-Hwa OhMatthias ZilbauerJeong-Ki MinCho-Rok JungJanghwan KimMi-Young SonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018) |
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spellingShingle |
Science Q Kwang Bo Jung Hana Lee Ye Seul Son Mi-Ok Lee Young-Dae Kim Soo Jin Oh Ohman Kwon Sunwha Cho Hyun-Soo Cho Dae-Soo Kim Jung-Hwa Oh Matthias Zilbauer Jeong-Ki Min Cho-Rok Jung Janghwan Kim Mi-Young Son Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids |
description |
Human pluripotent stem cell-derived intestinal organoids (hIOs) are a useful model with which to study intestinal development and disease, but they require in vivo maturation to resemble adult tissue. Here, the authors show that T lymphocyte-derived IL-2 induces hIO maturation in vitro through the activation of STAT3. |
format |
article |
author |
Kwang Bo Jung Hana Lee Ye Seul Son Mi-Ok Lee Young-Dae Kim Soo Jin Oh Ohman Kwon Sunwha Cho Hyun-Soo Cho Dae-Soo Kim Jung-Hwa Oh Matthias Zilbauer Jeong-Ki Min Cho-Rok Jung Janghwan Kim Mi-Young Son |
author_facet |
Kwang Bo Jung Hana Lee Ye Seul Son Mi-Ok Lee Young-Dae Kim Soo Jin Oh Ohman Kwon Sunwha Cho Hyun-Soo Cho Dae-Soo Kim Jung-Hwa Oh Matthias Zilbauer Jeong-Ki Min Cho-Rok Jung Janghwan Kim Mi-Young Son |
author_sort |
Kwang Bo Jung |
title |
Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids |
title_short |
Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids |
title_full |
Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids |
title_fullStr |
Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids |
title_full_unstemmed |
Interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids |
title_sort |
interleukin-2 induces the in vitro maturation of human pluripotent stem cell-derived intestinal organoids |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/a475745ef0d7496ba465e8488bf0de6b |
work_keys_str_mv |
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