Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies

Somatic mutations within antibody framework regions (FWR) can alter structural flexibility, but their role in maturation of broadly neutralizing antibodies (bnAbs) is unclear. Here the authors show how FWR mutations impact interdomain conformational flexibility and paratope plasticity during bnAb de...

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Autores principales:	Rory Henderson, Brian E. Watts, Hieu N. Ergin, Kara Anasti, Robert Parks, Shi-Mao Xia, Ashley Trama, Hua-Xin Liao, Kevin O. Saunders, Mattia Bonsignori, Kevin Wiehe, Barton F. Haynes, S. Munir Alam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a47579b2b60d4216bca8f50e6239686f
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spelling	oai:doaj.org-article:a47579b2b60d4216bca8f50e6239686f2021-12-02T17:01:31ZSelection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies10.1038/s41467-019-08415-72041-1723https://doaj.org/article/a47579b2b60d4216bca8f50e6239686f2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08415-7https://doaj.org/toc/2041-1723Somatic mutations within antibody framework regions (FWR) can alter structural flexibility, but their role in maturation of broadly neutralizing antibodies (bnAbs) is unclear. Here the authors show how FWR mutations impact interdomain conformational flexibility and paratope plasticity during bnAb development.Rory HendersonBrian E. WattsHieu N. ErginKara AnastiRobert ParksShi-Mao XiaAshley TramaHua-Xin LiaoKevin O. SaundersMattia BonsignoriKevin WieheBarton F. HaynesS. Munir AlamNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rory Henderson Brian E. Watts Hieu N. Ergin Kara Anasti Robert Parks Shi-Mao Xia Ashley Trama Hua-Xin Liao Kevin O. Saunders Mattia Bonsignori Kevin Wiehe Barton F. Haynes S. Munir Alam Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies
description	Somatic mutations within antibody framework regions (FWR) can alter structural flexibility, but their role in maturation of broadly neutralizing antibodies (bnAbs) is unclear. Here the authors show how FWR mutations impact interdomain conformational flexibility and paratope plasticity during bnAb development.
format	article
author	Rory Henderson Brian E. Watts Hieu N. Ergin Kara Anasti Robert Parks Shi-Mao Xia Ashley Trama Hua-Xin Liao Kevin O. Saunders Mattia Bonsignori Kevin Wiehe Barton F. Haynes S. Munir Alam
author_facet	Rory Henderson Brian E. Watts Hieu N. Ergin Kara Anasti Robert Parks Shi-Mao Xia Ashley Trama Hua-Xin Liao Kevin O. Saunders Mattia Bonsignori Kevin Wiehe Barton F. Haynes S. Munir Alam
author_sort	Rory Henderson
title	Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies
title_short	Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies
title_full	Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies
title_fullStr	Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies
title_full_unstemmed	Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies
title_sort	selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in hiv-1 broadly neutralizing antibodies
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a47579b2b60d4216bca8f50e6239686f
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Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies

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