Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy
Viruses trigger potent cytotoxic T cell responses, whereas anti-tumour immunity has been difficult to establish. Here the authors engineer a replicating viral delivery system for tumour-associated antigens, which induces alarmin release, innate activation and protective anti-tumour immunity in mice.
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Nature Portfolio
2017
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oai:doaj.org-article:a476030b446346deb07e1f28b441729c2021-12-02T15:39:05ZReplicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy10.1038/ncomms153272041-1723https://doaj.org/article/a476030b446346deb07e1f28b441729c2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15327https://doaj.org/toc/2041-1723Viruses trigger potent cytotoxic T cell responses, whereas anti-tumour immunity has been difficult to establish. Here the authors engineer a replicating viral delivery system for tumour-associated antigens, which induces alarmin release, innate activation and protective anti-tumour immunity in mice.Sandra M. KallertStephanie DarbreWeldy V. BonillaMario KreutzfeldtNicolas PagePhilipp MüllerMatthias KreuzalerMin LuStéphanie FavreFlorian KreppelMax LöhningSanjiv A. LutherAlfred ZippeliusDoron MerklerDaniel D. PinschewerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Sandra M. Kallert Stephanie Darbre Weldy V. Bonilla Mario Kreutzfeldt Nicolas Page Philipp Müller Matthias Kreuzaler Min Lu Stéphanie Favre Florian Kreppel Max Löhning Sanjiv A. Luther Alfred Zippelius Doron Merkler Daniel D. Pinschewer Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy |
| description |
Viruses trigger potent cytotoxic T cell responses, whereas anti-tumour immunity has been difficult to establish. Here the authors engineer a replicating viral delivery system for tumour-associated antigens, which induces alarmin release, innate activation and protective anti-tumour immunity in mice. |
| format |
article |
| author |
Sandra M. Kallert Stephanie Darbre Weldy V. Bonilla Mario Kreutzfeldt Nicolas Page Philipp Müller Matthias Kreuzaler Min Lu Stéphanie Favre Florian Kreppel Max Löhning Sanjiv A. Luther Alfred Zippelius Doron Merkler Daniel D. Pinschewer |
| author_facet |
Sandra M. Kallert Stephanie Darbre Weldy V. Bonilla Mario Kreutzfeldt Nicolas Page Philipp Müller Matthias Kreuzaler Min Lu Stéphanie Favre Florian Kreppel Max Löhning Sanjiv A. Luther Alfred Zippelius Doron Merkler Daniel D. Pinschewer |
| author_sort |
Sandra M. Kallert |
| title |
Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy |
| title_short |
Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy |
| title_full |
Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy |
| title_fullStr |
Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy |
| title_full_unstemmed |
Replicating viral vector platform exploits alarmin signals for potent CD8+ T cell-mediated tumour immunotherapy |
| title_sort |
replicating viral vector platform exploits alarmin signals for potent cd8+ t cell-mediated tumour immunotherapy |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/a476030b446346deb07e1f28b441729c |
| work_keys_str_mv |
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