Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia

Acute lymphoblastic leukaemia is characterized by chromosomal rearrangements. Here, the authors carry out RNA-sequencing on a large cohort of patients and identify recurrent rearrangements of MEF2D, which lead to increased transcriptional activity of the gene, and cellular transformation in vitro.

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Autores principales:	Zhaohui Gu, Michelle Churchman, Kathryn Roberts, Yongjin Li, Yu Liu, Richard C. Harvey, Kelly McCastlain, Shalini C. Reshmi, Debbie Payne-Turner, Ilaria Iacobucci, Ying Shao, I-Ming Chen, Marcus Valentine, Deqing Pei, Karen L. Mungall, Andrew J. Mungall, Yussanne Ma, Richard Moore, Marco Marra, Eileen Stonerock, Julie M. Gastier-Foster, Meenakshi Devidas, Yunfeng Dai, Brent Wood, Michael Borowitz, Eric E. Larsen, Kelly Maloney, Leonard A. Mattano Jr, Anne Angiolillo, Wanda L. Salzer, Michael J. Burke, Francesca Gianni, Orietta Spinelli, Jerald P. Radich, Mark D. Minden, Anthony V. Moorman, Bella Patel, Adele K. Fielding, Jacob M. Rowe, Selina M. Luger, Ravi Bhatia, Ibrahim Aldoss, Stephen J. Forman, Jessica Kohlschmidt, Krzysztof Mrózek, Guido Marcucci, Clara D. Bloomfield, Wendy Stock, Steven Kornblau, Hagop M. Kantarjian, Marina Konopleva, Elisabeth Paietta, Cheryl L. Willman, Mignon L. Loh, Stephen P. Hunger, Charles G. Mullighan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a47717c88ef24c69ad243e26e4c2ed5d
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spelling	oai:doaj.org-article:a47717c88ef24c69ad243e26e4c2ed5d2021-12-02T15:35:21ZGenomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia10.1038/ncomms133312041-1723https://doaj.org/article/a47717c88ef24c69ad243e26e4c2ed5d2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13331https://doaj.org/toc/2041-1723Acute lymphoblastic leukaemia is characterized by chromosomal rearrangements. Here, the authors carry out RNA-sequencing on a large cohort of patients and identify recurrent rearrangements of MEF2D, which lead to increased transcriptional activity of the gene, and cellular transformation in vitro.Zhaohui GuMichelle ChurchmanKathryn RobertsYongjin LiYu LiuRichard C. HarveyKelly McCastlainShalini C. ReshmiDebbie Payne-TurnerIlaria IacobucciYing ShaoI-Ming ChenMarcus ValentineDeqing PeiKaren L. MungallAndrew J. MungallYussanne MaRichard MooreMarco MarraEileen StonerockJulie M. Gastier-FosterMeenakshi DevidasYunfeng DaiBrent WoodMichael BorowitzEric E. LarsenKelly MaloneyLeonard A. Mattano JrAnne AngiolilloWanda L. SalzerMichael J. BurkeFrancesca GianniOrietta SpinelliJerald P. RadichMark D. MindenAnthony V. MoormanBella PatelAdele K. FieldingJacob M. RoweSelina M. LugerRavi BhatiaIbrahim AldossStephen J. FormanJessica KohlschmidtKrzysztof MrózekGuido MarcucciClara D. BloomfieldWendy StockSteven KornblauHagop M. KantarjianMarina KonoplevaElisabeth PaiettaCheryl L. WillmanMignon L. LohStephen P. HungerCharles G. MullighanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhaohui Gu Michelle Churchman Kathryn Roberts Yongjin Li Yu Liu Richard C. Harvey Kelly McCastlain Shalini C. Reshmi Debbie Payne-Turner Ilaria Iacobucci Ying Shao I-Ming Chen Marcus Valentine Deqing Pei Karen L. Mungall Andrew J. Mungall Yussanne Ma Richard Moore Marco Marra Eileen Stonerock Julie M. Gastier-Foster Meenakshi Devidas Yunfeng Dai Brent Wood Michael Borowitz Eric E. Larsen Kelly Maloney Leonard A. Mattano Jr Anne Angiolillo Wanda L. Salzer Michael J. Burke Francesca Gianni Orietta Spinelli Jerald P. Radich Mark D. Minden Anthony V. Moorman Bella Patel Adele K. Fielding Jacob M. Rowe Selina M. Luger Ravi Bhatia Ibrahim Aldoss Stephen J. Forman Jessica Kohlschmidt Krzysztof Mrózek Guido Marcucci Clara D. Bloomfield Wendy Stock Steven Kornblau Hagop M. Kantarjian Marina Konopleva Elisabeth Paietta Cheryl L. Willman Mignon L. Loh Stephen P. Hunger Charles G. Mullighan Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia
description	Acute lymphoblastic leukaemia is characterized by chromosomal rearrangements. Here, the authors carry out RNA-sequencing on a large cohort of patients and identify recurrent rearrangements of MEF2D, which lead to increased transcriptional activity of the gene, and cellular transformation in vitro.
format	article
author	Zhaohui Gu Michelle Churchman Kathryn Roberts Yongjin Li Yu Liu Richard C. Harvey Kelly McCastlain Shalini C. Reshmi Debbie Payne-Turner Ilaria Iacobucci Ying Shao I-Ming Chen Marcus Valentine Deqing Pei Karen L. Mungall Andrew J. Mungall Yussanne Ma Richard Moore Marco Marra Eileen Stonerock Julie M. Gastier-Foster Meenakshi Devidas Yunfeng Dai Brent Wood Michael Borowitz Eric E. Larsen Kelly Maloney Leonard A. Mattano Jr Anne Angiolillo Wanda L. Salzer Michael J. Burke Francesca Gianni Orietta Spinelli Jerald P. Radich Mark D. Minden Anthony V. Moorman Bella Patel Adele K. Fielding Jacob M. Rowe Selina M. Luger Ravi Bhatia Ibrahim Aldoss Stephen J. Forman Jessica Kohlschmidt Krzysztof Mrózek Guido Marcucci Clara D. Bloomfield Wendy Stock Steven Kornblau Hagop M. Kantarjian Marina Konopleva Elisabeth Paietta Cheryl L. Willman Mignon L. Loh Stephen P. Hunger Charles G. Mullighan
author_facet	Zhaohui Gu Michelle Churchman Kathryn Roberts Yongjin Li Yu Liu Richard C. Harvey Kelly McCastlain Shalini C. Reshmi Debbie Payne-Turner Ilaria Iacobucci Ying Shao I-Ming Chen Marcus Valentine Deqing Pei Karen L. Mungall Andrew J. Mungall Yussanne Ma Richard Moore Marco Marra Eileen Stonerock Julie M. Gastier-Foster Meenakshi Devidas Yunfeng Dai Brent Wood Michael Borowitz Eric E. Larsen Kelly Maloney Leonard A. Mattano Jr Anne Angiolillo Wanda L. Salzer Michael J. Burke Francesca Gianni Orietta Spinelli Jerald P. Radich Mark D. Minden Anthony V. Moorman Bella Patel Adele K. Fielding Jacob M. Rowe Selina M. Luger Ravi Bhatia Ibrahim Aldoss Stephen J. Forman Jessica Kohlschmidt Krzysztof Mrózek Guido Marcucci Clara D. Bloomfield Wendy Stock Steven Kornblau Hagop M. Kantarjian Marina Konopleva Elisabeth Paietta Cheryl L. Willman Mignon L. Loh Stephen P. Hunger Charles G. Mullighan
author_sort	Zhaohui Gu
title	Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia
title_short	Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia
title_full	Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia
title_fullStr	Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia
title_full_unstemmed	Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia
title_sort	genomic analyses identify recurrent mef2d fusions in acute lymphoblastic leukaemia
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/a47717c88ef24c69ad243e26e4c2ed5d
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Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia

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