Comparison of the Effects of Clozapine, Olanzapine and Risperidone with Haloperidol on Fasting Blood Level of Glucose, Cholesterol and Triglyceride in Patients with Psychotic Disorders

BACKGROUND AND OBJECTIVE: Atypical antipsychotic drugs are first line treatment for psychotic disorders and well tolerated by the patients because of less extra pyramidal side effects and better efficacies. But there are different reports about metabolic dysfunctions that are associated with use of...

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Autores principales:	A Masoudzadeh, M Mahmoodi, J Torabizadeh, M Onagh
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2009
Materias:	antipsychotic agents blood glucose cholesterol triglyceride Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a4781bc2e40349ab941377766d77e91d
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spelling	oai:doaj.org-article:a4781bc2e40349ab941377766d77e91d2021-11-10T09:02:43ZComparison of the Effects of Clozapine, Olanzapine and Risperidone with Haloperidol on Fasting Blood Level of Glucose, Cholesterol and Triglyceride in Patients with Psychotic Disorders1561-41072251-7170https://doaj.org/article/a4781bc2e40349ab941377766d77e91d2009-06-01T00:00:00Zhttp://jbums.org/article-1-3124-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Atypical antipsychotic drugs are first line treatment for psychotic disorders and well tolerated by the patients because of less extra pyramidal side effects and better efficacies. But there are different reports about metabolic dysfunctions that are associated with use of these drugs. So the aim of this study was to compare these side effects among atypical antipsychotic drugs (clozapine, olanzapine, risperidone) and haloperidol.METHODS In this cohort study psychotic patients (according to DSM IV criteria) due to their response to previous treatment regiment or new onset of disorder were received clozapine, olanzapine, risperidone (atypical group) and haloperidol (typical group). Patients who were resistant to other drugs treated with clozapine and bipolar patients received olanzapine. Fasting blood level of glucose, cholesterol and triglyceride of all patients were measured before initiating and six weeks after drug administration. FINDINGS: 75 inpatients or out patients with variety of psychotic disorders enrolled the study, as 45 patients were in atypical and 30 in typical drug groups. Two groups were matched by age and sex. The mean level of fasting blood glucose, triglyceride and cholesterol of patients in atypical drug group before treatment was 90.7%±16.2, 144±35.5 and 163±25.1 mg/dl, respectively and in typical group it was 88.6±27, 162.3±38.5 and 164.2±25 mg/dl, respectively. The mean level of fasting blood glucose, triglyceride and cholesterol of patients in atypical drug group after treatment was 94.4±13.1, 168±50.8 and 168.6±33.5 mg/dl, respectively and in typical group was 92.9±27, 175.3±45.9 and 164±26.5 mg/dl, respectively that showed no significant difference. CONCLUSION: Antipsychotic drugs (either typical or atypical) didn’t increase fasting blood level of glucose, cholesterol and triglyceride in psychotic patients.A MasoudzadehM Mahmoodi,J TorabizadehM OnaghBabol University of Medical Sciencesarticleantipsychotic agentsblood glucosecholesteroltriglycerideMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 11, Iss 2, Pp 25-30 (2009)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	antipsychotic agents blood glucose cholesterol triglyceride Medicine R Medicine (General) R5-920
spellingShingle	antipsychotic agents blood glucose cholesterol triglyceride Medicine R Medicine (General) R5-920 A Masoudzadeh M Mahmoodi, J Torabizadeh M Onagh Comparison of the Effects of Clozapine, Olanzapine and Risperidone with Haloperidol on Fasting Blood Level of Glucose, Cholesterol and Triglyceride in Patients with Psychotic Disorders
description	BACKGROUND AND OBJECTIVE: Atypical antipsychotic drugs are first line treatment for psychotic disorders and well tolerated by the patients because of less extra pyramidal side effects and better efficacies. But there are different reports about metabolic dysfunctions that are associated with use of these drugs. So the aim of this study was to compare these side effects among atypical antipsychotic drugs (clozapine, olanzapine, risperidone) and haloperidol.METHODS In this cohort study psychotic patients (according to DSM IV criteria) due to their response to previous treatment regiment or new onset of disorder were received clozapine, olanzapine, risperidone (atypical group) and haloperidol (typical group). Patients who were resistant to other drugs treated with clozapine and bipolar patients received olanzapine. Fasting blood level of glucose, cholesterol and triglyceride of all patients were measured before initiating and six weeks after drug administration. FINDINGS: 75 inpatients or out patients with variety of psychotic disorders enrolled the study, as 45 patients were in atypical and 30 in typical drug groups. Two groups were matched by age and sex. The mean level of fasting blood glucose, triglyceride and cholesterol of patients in atypical drug group before treatment was 90.7%±16.2, 144±35.5 and 163±25.1 mg/dl, respectively and in typical group it was 88.6±27, 162.3±38.5 and 164.2±25 mg/dl, respectively. The mean level of fasting blood glucose, triglyceride and cholesterol of patients in atypical drug group after treatment was 94.4±13.1, 168±50.8 and 168.6±33.5 mg/dl, respectively and in typical group was 92.9±27, 175.3±45.9 and 164±26.5 mg/dl, respectively that showed no significant difference. CONCLUSION: Antipsychotic drugs (either typical or atypical) didn’t increase fasting blood level of glucose, cholesterol and triglyceride in psychotic patients.
format	article
author	A Masoudzadeh M Mahmoodi, J Torabizadeh M Onagh
author_facet	A Masoudzadeh M Mahmoodi, J Torabizadeh M Onagh
author_sort	A Masoudzadeh
title	Comparison of the Effects of Clozapine, Olanzapine and Risperidone with Haloperidol on Fasting Blood Level of Glucose, Cholesterol and Triglyceride in Patients with Psychotic Disorders
title_short	Comparison of the Effects of Clozapine, Olanzapine and Risperidone with Haloperidol on Fasting Blood Level of Glucose, Cholesterol and Triglyceride in Patients with Psychotic Disorders
title_full	Comparison of the Effects of Clozapine, Olanzapine and Risperidone with Haloperidol on Fasting Blood Level of Glucose, Cholesterol and Triglyceride in Patients with Psychotic Disorders
title_fullStr	Comparison of the Effects of Clozapine, Olanzapine and Risperidone with Haloperidol on Fasting Blood Level of Glucose, Cholesterol and Triglyceride in Patients with Psychotic Disorders
title_full_unstemmed	Comparison of the Effects of Clozapine, Olanzapine and Risperidone with Haloperidol on Fasting Blood Level of Glucose, Cholesterol and Triglyceride in Patients with Psychotic Disorders
title_sort	comparison of the effects of clozapine, olanzapine and risperidone with haloperidol on fasting blood level of glucose, cholesterol and triglyceride in patients with psychotic disorders
publisher	Babol University of Medical Sciences
publishDate	2009
url	https://doaj.org/article/a4781bc2e40349ab941377766d77e91d
work_keys_str_mv	AT amasoudzadeh comparisonoftheeffectsofclozapineolanzapineandrisperidonewithhaloperidolonfastingbloodlevelofglucosecholesterolandtriglycerideinpatientswithpsychoticdisorders AT mmahmoodi comparisonoftheeffectsofclozapineolanzapineandrisperidonewithhaloperidolonfastingbloodlevelofglucosecholesterolandtriglycerideinpatientswithpsychoticdisorders AT jtorabizadeh comparisonoftheeffectsofclozapineolanzapineandrisperidonewithhaloperidolonfastingbloodlevelofglucosecholesterolandtriglycerideinpatientswithpsychoticdisorders AT monagh comparisonoftheeffectsofclozapineolanzapineandrisperidonewithhaloperidolonfastingbloodlevelofglucosecholesterolandtriglycerideinpatientswithpsychoticdisorders
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Comparison of the Effects of Clozapine, Olanzapine and Risperidone with Haloperidol on Fasting Blood Level of Glucose, Cholesterol and Triglyceride in Patients with Psychotic Disorders

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