Developing a Technique for the Imaging-Based Measurement of ACL Elongation: A Proof of Principle

Towards the goal of obtaining non-invasive biomarkers reflecting the anterior cruciate ligament’s (ACL) loading capacity, this project aimed to develop a magnetic resonance imaging (MRI)-based method facilitating the measurement of ACL elongations during the execution of knee stress tests. An MRI-co...

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Autores principales:	Robert Csapo, Dieter Heinrich, Andrew D. Vigotsky, Christian Marx, Shantanu Sinha, Christian Fink
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	stress strain stiffness mechanical properties Lachman test anterior tibial translation Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a47a30b1fd8b44e7b717a1df97e73aaa
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spelling	oai:doaj.org-article:a47a30b1fd8b44e7b717a1df97e73aaa2021-11-25T17:21:50ZDeveloping a Technique for the Imaging-Based Measurement of ACL Elongation: A Proof of Principle10.3390/diagnostics111121262075-4418https://doaj.org/article/a47a30b1fd8b44e7b717a1df97e73aaa2021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2126https://doaj.org/toc/2075-4418Towards the goal of obtaining non-invasive biomarkers reflecting the anterior cruciate ligament’s (ACL) loading capacity, this project aimed to develop a magnetic resonance imaging (MRI)-based method facilitating the measurement of ACL elongations during the execution of knee stress tests. An MRI-compatible, computer-controlled, and pneumatically driven knee loading device was designed to perform Lachman-like tests and induce ACL strain. A human cadaveric leg was used for test purposes. During the execution of the stress tests, a triggered real-time cine MRI sequence with a temporal resolution of 10 Hz was acquired in a parasagittal plane to capture the resultant ACL elongations. To test the accuracy of these measurements, the results were compared to in situ data of ACL elongation that were acquired by measuring the length changes of a surgical wire directly sutured to the ACL’s anteromedial bundle. The MRI-based ACL elongations ranged between 0.7 and 1.7 mm and agreed very well with in situ data (root mean square errors, RMSEs ≤ 0.25 mm), although peak elongation rates were underestimated by the MRI (RMSEs 0.19–0.36 mm/s). The high accuracy of elongation measurements underlines the potential of the technique to yield an imaging-based biomarker of the ACL’s loading capacity.Robert CsapoDieter HeinrichAndrew D. VigotskyChristian MarxShantanu SinhaChristian FinkMDPI AGarticlestressstrainstiffnessmechanical propertiesLachman testanterior tibial translationMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2126, p 2126 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stress strain stiffness mechanical properties Lachman test anterior tibial translation Medicine (General) R5-920
spellingShingle	stress strain stiffness mechanical properties Lachman test anterior tibial translation Medicine (General) R5-920 Robert Csapo Dieter Heinrich Andrew D. Vigotsky Christian Marx Shantanu Sinha Christian Fink Developing a Technique for the Imaging-Based Measurement of ACL Elongation: A Proof of Principle
description	Towards the goal of obtaining non-invasive biomarkers reflecting the anterior cruciate ligament’s (ACL) loading capacity, this project aimed to develop a magnetic resonance imaging (MRI)-based method facilitating the measurement of ACL elongations during the execution of knee stress tests. An MRI-compatible, computer-controlled, and pneumatically driven knee loading device was designed to perform Lachman-like tests and induce ACL strain. A human cadaveric leg was used for test purposes. During the execution of the stress tests, a triggered real-time cine MRI sequence with a temporal resolution of 10 Hz was acquired in a parasagittal plane to capture the resultant ACL elongations. To test the accuracy of these measurements, the results were compared to in situ data of ACL elongation that were acquired by measuring the length changes of a surgical wire directly sutured to the ACL’s anteromedial bundle. The MRI-based ACL elongations ranged between 0.7 and 1.7 mm and agreed very well with in situ data (root mean square errors, RMSEs ≤ 0.25 mm), although peak elongation rates were underestimated by the MRI (RMSEs 0.19–0.36 mm/s). The high accuracy of elongation measurements underlines the potential of the technique to yield an imaging-based biomarker of the ACL’s loading capacity.
format	article
author	Robert Csapo Dieter Heinrich Andrew D. Vigotsky Christian Marx Shantanu Sinha Christian Fink
author_facet	Robert Csapo Dieter Heinrich Andrew D. Vigotsky Christian Marx Shantanu Sinha Christian Fink
author_sort	Robert Csapo
title	Developing a Technique for the Imaging-Based Measurement of ACL Elongation: A Proof of Principle
title_short	Developing a Technique for the Imaging-Based Measurement of ACL Elongation: A Proof of Principle
title_full	Developing a Technique for the Imaging-Based Measurement of ACL Elongation: A Proof of Principle
title_fullStr	Developing a Technique for the Imaging-Based Measurement of ACL Elongation: A Proof of Principle
title_full_unstemmed	Developing a Technique for the Imaging-Based Measurement of ACL Elongation: A Proof of Principle
title_sort	developing a technique for the imaging-based measurement of acl elongation: a proof of principle
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a47a30b1fd8b44e7b717a1df97e73aaa
work_keys_str_mv	AT robertcsapo developingatechniquefortheimagingbasedmeasurementofaclelongationaproofofprinciple AT dieterheinrich developingatechniquefortheimagingbasedmeasurementofaclelongationaproofofprinciple AT andrewdvigotsky developingatechniquefortheimagingbasedmeasurementofaclelongationaproofofprinciple AT christianmarx developingatechniquefortheimagingbasedmeasurementofaclelongationaproofofprinciple AT shantanusinha developingatechniquefortheimagingbasedmeasurementofaclelongationaproofofprinciple AT christianfink developingatechniquefortheimagingbasedmeasurementofaclelongationaproofofprinciple
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Developing a Technique for the Imaging-Based Measurement of ACL Elongation: A Proof of Principle

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