The Genetic Profile and Serum Level of IL-8 Are Associated with Chronic Hepatitis B and C Virus Infection
The present study evaluated the <i>IL8</i>-251 A/T polymorphism in samples from 74 patients with chronic hepatitis B (HBV), 100 patients with chronic hepatitis C (HCV), and 300 healthy donors (CG). The correlations of this polymorphism with plasma IL-8 and disease stage were calculated....
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| Autores principales: | , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/a47b80f0036f47518c40194bd1a8290e |
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| Sumario: | The present study evaluated the <i>IL8</i>-251 A/T polymorphism in samples from 74 patients with chronic hepatitis B (HBV), 100 patients with chronic hepatitis C (HCV), and 300 healthy donors (CG). The correlations of this polymorphism with plasma IL-8 and disease stage were calculated. Polymorphisms were identified by real-time PCR. IL-8 was measured by enzyme-linked immunosorbent assay. The <i>IL8</i>-251 A/T genotype was not associated with susceptibility to infection by HBV or HCV. The wild-type allele (A) was associated with higher levels of inflammation (<i>p</i> = 0.0464) and fibrosis scores (<i>p</i> = 0.0016) in the HBV group, representing an increased risk for increased inflammatory activity (<i>OR</i> = 1.84; <i>p</i> = 0.0464) and for high fibrosis scores (<i>OR</i> = 2.63; <i>p</i> = 0.0016). Viral load was higher in HBV patients with polymorphic genotypes (TA and TT) at the <i>IL8</i>-251 A/T polymorphism than in those with the wild-type genotype (<i>p</i> = 0.0272 and <i>p</i> = 0.0464, respectively). Plasma IL-8 was higher among patients infected with HBV or HCV than in the control group (<i>p</i> = 0.0445 and <i>p</i> = 0.0001, respectively). The polymorphic genotype was associated with lower IL-8 than the wild-type genotype in the HBV group (<i>p</i> = 0.0239) and the HCV group (<i>p</i> = 0.0372). The wild-type genotype for <i>IL8</i>-251 A/T and high IL-8 were associated with a worse prognosis for infections; therefore, they may contribute to viral persistence and the development of more severe forms of chronic viral liver diseases. |
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