Long-Term Outcome Measures of Repeated Non-Animal Stabilized Hyaluronic Acid (Durolane) Injections in Osteoarthritis: A 6-Year Cohort Study with 623 Consecutive Patients

Georgia Carney,1,2 Andrew Harrison,3 Jane Fitzpatrick1,2,4 1Joint Health Institute, Melbourne, Victoria, Australia; 2Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria, Australia; 3Bioventus International, Hoofddorp, 2131 LS, Netherlands; 4Australasi...

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Autores principales:	Carney G, Harrison A, Fitzpatrick J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	biological treatment joint hyaluronic acid intra-articular injection long-term pain relief. Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/a47c1fd149ee4b119e6ed223eb28e034
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spelling	oai:doaj.org-article:a47c1fd149ee4b119e6ed223eb28e0342021-12-02T18:49:48ZLong-Term Outcome Measures of Repeated Non-Animal Stabilized Hyaluronic Acid (Durolane) Injections in Osteoarthritis: A 6-Year Cohort Study with 623 Consecutive Patients1179-156Xhttps://doaj.org/article/a47c1fd149ee4b119e6ed223eb28e0342021-09-01T00:00:00Zhttps://www.dovepress.com/long-term-outcome-measures-of-repeated-non-animal-stabilized-hyaluroni-peer-reviewed-fulltext-article-OARRRhttps://doaj.org/toc/1179-156XGeorgia Carney,1,2 Andrew Harrison,3 Jane Fitzpatrick1,2,4 1Joint Health Institute, Melbourne, Victoria, Australia; 2Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria, Australia; 3Bioventus International, Hoofddorp, 2131 LS, Netherlands; 4Australasian College of Sport and Exercise Physicians, Melbourne, Victoria, AustraliaCorrespondence: Jane Fitzpatrick Level 7, Alan Gilbert Building 161 Barry Street University of Melbourne, Parkville, Victoria, 3010, AustraliaTel +61 3 9429 6444Email jane.fitzpatrick@unimelb.edu.au Twitter @sportsdocPurpose: To determine the duration of symptom relief following repeated administration of hyaluronic acid injections for osteoarthritis.Patients and Methods: This was a 6-year observational study with 623 consecutive patients who had received hyaluronic acid injections. The primary outcome measure was the mean time between injections measured in days. Classical one-sample 2-sided t-tests, one-way analysis of variances and post-hoc analyses were performed to determine if there were statistically significant differences between age, gender, radiographic severity and the type of joints injected. All patients were invited to complete an online post-treatment experience and satisfaction survey.Results: The analysis included 727 joints (mean Kellgren-Lawrence grade, 2.9 ± 0.8 (range 2– 4)) in 623 patients (297 (47.7%) male; mean age at first injection, 57.8 ± 12.7 years (range 21.2– 92.1)). Patients ranged from having 1– 8 injections per joint. The mean time between injections in days was 466.8 ± 321.7 (2nd injection, 157 joints), 400.5 ± 164.7 (3rd injection, 58 joints), 378.2 ± 223.1 (4th injection, 27 joints), 405.3 ± 216.3 (5th injection, 7 joints), 268.4 ± 104.4 (6th injection, 5 joints), 289.8 ± 99.4 (7th injection, 4 joints), and 272.5 ± 33.2 (8th injection, 2 joints). Patients with grades 2 and 3 compared to grade 4 osteoarthritis experienced a longer time between injections (F (2, 154) = 3.53, p = 0.0316). No statistically significant differences were observed between age, gender, or joint groups. The survey included 233 participants (109 (46.8% male)). A total of 144 respondents (64.9%) recommended hyaluronic acid injections for osteoarthritis.Conclusion: Pain relief from hyaluronic acid injections was sustained for on average 466.8 days post initial treatment. Patients who received subsequent 3rd, 4th, and 5th injections also experienced extended duration of benefit. Patients with grades 2 or 3 osteoarthritis are more likely to experience a longer duration of relief.Keywords: biological treatment, joint, hyaluronic acid, intra-articular injection, long-term, pain reliefCarney GHarrison AFitzpatrick JDove Medical Pressarticlebiological treatmentjointhyaluronic acidintra-articular injectionlong-termpain relief.Diseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 13, Pp 285-292 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biological treatment joint hyaluronic acid intra-articular injection long-term pain relief. Diseases of the musculoskeletal system RC925-935
spellingShingle	biological treatment joint hyaluronic acid intra-articular injection long-term pain relief. Diseases of the musculoskeletal system RC925-935 Carney G Harrison A Fitzpatrick J Long-Term Outcome Measures of Repeated Non-Animal Stabilized Hyaluronic Acid (Durolane) Injections in Osteoarthritis: A 6-Year Cohort Study with 623 Consecutive Patients
description	Georgia Carney,1,2 Andrew Harrison,3 Jane Fitzpatrick1,2,4 1Joint Health Institute, Melbourne, Victoria, Australia; 2Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria, Australia; 3Bioventus International, Hoofddorp, 2131 LS, Netherlands; 4Australasian College of Sport and Exercise Physicians, Melbourne, Victoria, AustraliaCorrespondence: Jane Fitzpatrick Level 7, Alan Gilbert Building 161 Barry Street University of Melbourne, Parkville, Victoria, 3010, AustraliaTel +61 3 9429 6444Email jane.fitzpatrick@unimelb.edu.au Twitter @sportsdocPurpose: To determine the duration of symptom relief following repeated administration of hyaluronic acid injections for osteoarthritis.Patients and Methods: This was a 6-year observational study with 623 consecutive patients who had received hyaluronic acid injections. The primary outcome measure was the mean time between injections measured in days. Classical one-sample 2-sided t-tests, one-way analysis of variances and post-hoc analyses were performed to determine if there were statistically significant differences between age, gender, radiographic severity and the type of joints injected. All patients were invited to complete an online post-treatment experience and satisfaction survey.Results: The analysis included 727 joints (mean Kellgren-Lawrence grade, 2.9 ± 0.8 (range 2– 4)) in 623 patients (297 (47.7%) male; mean age at first injection, 57.8 ± 12.7 years (range 21.2– 92.1)). Patients ranged from having 1– 8 injections per joint. The mean time between injections in days was 466.8 ± 321.7 (2nd injection, 157 joints), 400.5 ± 164.7 (3rd injection, 58 joints), 378.2 ± 223.1 (4th injection, 27 joints), 405.3 ± 216.3 (5th injection, 7 joints), 268.4 ± 104.4 (6th injection, 5 joints), 289.8 ± 99.4 (7th injection, 4 joints), and 272.5 ± 33.2 (8th injection, 2 joints). Patients with grades 2 and 3 compared to grade 4 osteoarthritis experienced a longer time between injections (F (2, 154) = 3.53, p = 0.0316). No statistically significant differences were observed between age, gender, or joint groups. The survey included 233 participants (109 (46.8% male)). A total of 144 respondents (64.9%) recommended hyaluronic acid injections for osteoarthritis.Conclusion: Pain relief from hyaluronic acid injections was sustained for on average 466.8 days post initial treatment. Patients who received subsequent 3rd, 4th, and 5th injections also experienced extended duration of benefit. Patients with grades 2 or 3 osteoarthritis are more likely to experience a longer duration of relief.Keywords: biological treatment, joint, hyaluronic acid, intra-articular injection, long-term, pain relief
format	article
author	Carney G Harrison A Fitzpatrick J
author_facet	Carney G Harrison A Fitzpatrick J
author_sort	Carney G
title	Long-Term Outcome Measures of Repeated Non-Animal Stabilized Hyaluronic Acid (Durolane) Injections in Osteoarthritis: A 6-Year Cohort Study with 623 Consecutive Patients
title_short	Long-Term Outcome Measures of Repeated Non-Animal Stabilized Hyaluronic Acid (Durolane) Injections in Osteoarthritis: A 6-Year Cohort Study with 623 Consecutive Patients
title_full	Long-Term Outcome Measures of Repeated Non-Animal Stabilized Hyaluronic Acid (Durolane) Injections in Osteoarthritis: A 6-Year Cohort Study with 623 Consecutive Patients
title_fullStr	Long-Term Outcome Measures of Repeated Non-Animal Stabilized Hyaluronic Acid (Durolane) Injections in Osteoarthritis: A 6-Year Cohort Study with 623 Consecutive Patients
title_full_unstemmed	Long-Term Outcome Measures of Repeated Non-Animal Stabilized Hyaluronic Acid (Durolane) Injections in Osteoarthritis: A 6-Year Cohort Study with 623 Consecutive Patients
title_sort	long-term outcome measures of repeated non-animal stabilized hyaluronic acid (durolane) injections in osteoarthritis: a 6-year cohort study with 623 consecutive patients
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/a47c1fd149ee4b119e6ed223eb28e034
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Long-Term Outcome Measures of Repeated Non-Animal Stabilized Hyaluronic Acid (Durolane) Injections in Osteoarthritis: A 6-Year Cohort Study with 623 Consecutive Patients

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