Altered fecal microbiota composition in individuals who abuse methamphetamine

Abstract As a severe public health problem, methamphetamine (METH) abuse places a heavy burden on families and society. A growing amount of evidence has indicated communication between gut microbiota and the CNS in drug addiction, with associations to neural, endocrine and immune pathways. Thus, we...

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Autores principales:	Yongde Yang, Xuan Yu, Xuebing Liu, Guangya Liu, Kuan Zeng, Gang Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a47daeb098d644d4898d32f101c1bb99
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spelling	oai:doaj.org-article:a47daeb098d644d4898d32f101c1bb992021-12-02T18:50:48ZAltered fecal microbiota composition in individuals who abuse methamphetamine10.1038/s41598-021-97548-12045-2322https://doaj.org/article/a47daeb098d644d4898d32f101c1bb992021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97548-1https://doaj.org/toc/2045-2322Abstract As a severe public health problem, methamphetamine (METH) abuse places a heavy burden on families and society. A growing amount of evidence has indicated communication between gut microbiota and the CNS in drug addiction, with associations to neural, endocrine and immune pathways. Thus, we searched for alterations in the gut microbiota and their potential effects in METH users through 16S rRNA gene sequencing. A decreased Shannon index indicated lower bacterial diversity in the METH users than in the age-matched control group. The gut microbial community composition in the METH users was also altered, including reductions in Deltaproteobacteria and Bacteroidaceae abundances and increases in Sphingomonadales, Xanthomonadales, Romboutsia and Lachnospiraceae abundances. Moreover, the Fusobacteria abundance was correlated with the duration of METH use. Enterobacteriaceae, Ruminococcaceae, Bacteroides, and Faecalibacterium had statistically significant correlations with items related to the positive and negative symptoms of schizophrenia and to general psychopathology in the METH users, and all have previously been reported to be altered in individuals with psychotic syndromes, especially depression. Abstraction, one of the items of the cognitive assessment, was positively related to Blautia. These findings revealed alterations in the gut microbiota of METH users, and these alterations may play a role in psychotic syndrome and cognitive impairment. Although the mechanisms behind the links between these disorders and METH abuse are unknown, the relationships may indicate similarities in the pathogenesis of psychosis induced by METH abuse and other causes, providing a new paradigm for addiction and METH use disorder treatment.Yongde YangXuan YuXuebing LiuGuangya LiuKuan ZengGang WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yongde Yang Xuan Yu Xuebing Liu Guangya Liu Kuan Zeng Gang Wang Altered fecal microbiota composition in individuals who abuse methamphetamine
description	Abstract As a severe public health problem, methamphetamine (METH) abuse places a heavy burden on families and society. A growing amount of evidence has indicated communication between gut microbiota and the CNS in drug addiction, with associations to neural, endocrine and immune pathways. Thus, we searched for alterations in the gut microbiota and their potential effects in METH users through 16S rRNA gene sequencing. A decreased Shannon index indicated lower bacterial diversity in the METH users than in the age-matched control group. The gut microbial community composition in the METH users was also altered, including reductions in Deltaproteobacteria and Bacteroidaceae abundances and increases in Sphingomonadales, Xanthomonadales, Romboutsia and Lachnospiraceae abundances. Moreover, the Fusobacteria abundance was correlated with the duration of METH use. Enterobacteriaceae, Ruminococcaceae, Bacteroides, and Faecalibacterium had statistically significant correlations with items related to the positive and negative symptoms of schizophrenia and to general psychopathology in the METH users, and all have previously been reported to be altered in individuals with psychotic syndromes, especially depression. Abstraction, one of the items of the cognitive assessment, was positively related to Blautia. These findings revealed alterations in the gut microbiota of METH users, and these alterations may play a role in psychotic syndrome and cognitive impairment. Although the mechanisms behind the links between these disorders and METH abuse are unknown, the relationships may indicate similarities in the pathogenesis of psychosis induced by METH abuse and other causes, providing a new paradigm for addiction and METH use disorder treatment.
format	article
author	Yongde Yang Xuan Yu Xuebing Liu Guangya Liu Kuan Zeng Gang Wang
author_facet	Yongde Yang Xuan Yu Xuebing Liu Guangya Liu Kuan Zeng Gang Wang
author_sort	Yongde Yang
title	Altered fecal microbiota composition in individuals who abuse methamphetamine
title_short	Altered fecal microbiota composition in individuals who abuse methamphetamine
title_full	Altered fecal microbiota composition in individuals who abuse methamphetamine
title_fullStr	Altered fecal microbiota composition in individuals who abuse methamphetamine
title_full_unstemmed	Altered fecal microbiota composition in individuals who abuse methamphetamine
title_sort	altered fecal microbiota composition in individuals who abuse methamphetamine
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a47daeb098d644d4898d32f101c1bb99
work_keys_str_mv	AT yongdeyang alteredfecalmicrobiotacompositioninindividualswhoabusemethamphetamine AT xuanyu alteredfecalmicrobiotacompositioninindividualswhoabusemethamphetamine AT xuebingliu alteredfecalmicrobiotacompositioninindividualswhoabusemethamphetamine AT guangyaliu alteredfecalmicrobiotacompositioninindividualswhoabusemethamphetamine AT kuanzeng alteredfecalmicrobiotacompositioninindividualswhoabusemethamphetamine AT gangwang alteredfecalmicrobiotacompositioninindividualswhoabusemethamphetamine
_version_	1718377522628919296

Altered fecal microbiota composition in individuals who abuse methamphetamine

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