$Hair follicle growth by stromal vascular fraction-enhanced adipose transplantation in baldness$
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Hair follicle growth by stromal vascular fraction-enhanced adipose transplantation in baldness

David Perez-Meza,1 Craig Ziering,2 Marcos Sforza,3 Ganesh Krishnan,4 Edward Ball,5 Eric Daniels6 1Ziering Medical, Marbella, Spain; 2Ziering Medical, Los Angeles, CA, USA; 3The Hospital Group, Bromsgrove, Worcestershire, 4Ziering Medical, Birmingham, 5Ziering Medical, London, UK; 6Kerastem Technolog...

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Autores principales:	Perez-Meza D, Ziering C, Sforza M, Krishnan G, Ball E, Daniels E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	stem cell alopecia adipose stromal vascular fraction transplantation Cytology QH573-671
Acceso en línea:	https://doaj.org/article/a484e7d1e7404ebbb034fe1a84bd64ec
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spelling	oai:doaj.org-article:a484e7d1e7404ebbb034fe1a84bd64ec2021-12-02T07:09:07ZHair follicle growth by stromal vascular fraction-enhanced adipose transplantation in baldness1178-6957https://doaj.org/article/a484e7d1e7404ebbb034fe1a84bd64ec2017-07-01T00:00:00Zhttps://www.dovepress.com/hair-follicle-growth-by-stromal-vascular-fraction-enhanced-adipose-tra-peer-reviewed-article-SCCAAhttps://doaj.org/toc/1178-6957David Perez-Meza,1 Craig Ziering,2 Marcos Sforza,3 Ganesh Krishnan,4 Edward Ball,5 Eric Daniels6 1Ziering Medical, Marbella, Spain; 2Ziering Medical, Los Angeles, CA, USA; 3The Hospital Group, Bromsgrove, Worcestershire, 4Ziering Medical, Birmingham, 5Ziering Medical, London, UK; 6Kerastem Technologies, San Diego, CA, USA Abstract: Great interest remains in finding new and emerging therapies for the treatment of male and female pattern hair loss. The autologous fat grafting technique is >100 years old, with a recent and dramatic increase in clinical experience over the past 10–15 years. Recently, in 2001, Zuk et al published the presence of adipose-derived stem cells, and abundant research has shown that adipose is a complex, biological active, and important tissue. Festa et al, in 2011, reported that adipocyte lineage cells support the stem cell niche and help drive the complex hair growth cycle. Adipose-derived regenerative cells (also known as stromal vascular fraction [SVF]) is a heterogeneous group of noncultured cells that can be reliably extracted from adipose by using automated systems, and these cells work largely by paracrine mechanisms to support adipocyte viability. While, today, autologous fat is transplanted primarily for esthetic and reconstructive volume, surgeons have previously reported positive skin and hair changes posttransplantation. This follicular regenerative approach is intriguing and raises the possibility that one can drive or restore the hair cycle in male and female pattern baldness by stimulating the niche with autologous fat enriched with SVF. In this first of a kind patient series, the authors report on the safety, tolerability, and quantitative, as well as photographic changes, in a group of patients with early genetic alopecia treated with subcutaneous scalp injection of enriched adipose tissue. The findings suggest that scalp stem cell-enriched fat grafting may represent a promising alternative approach to treating baldness in men and women. Keywords: stem cell, alopecia, adipose, stromal vascular fraction, transplantationPerez-Meza DZiering CSforza MKrishnan GBall EDaniels EDove Medical Pressarticlestem cellalopeciaadiposestromal vascular fractiontransplantationCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol Volume 10, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	stem cell alopecia adipose stromal vascular fraction transplantation Cytology QH573-671
spellingShingle	stem cell alopecia adipose stromal vascular fraction transplantation Cytology QH573-671 Perez-Meza D Ziering C Sforza M Krishnan G Ball E Daniels E Hair follicle growth by stromal vascular fraction-enhanced adipose transplantation in baldness
description	David Perez-Meza,1 Craig Ziering,2 Marcos Sforza,3 Ganesh Krishnan,4 Edward Ball,5 Eric Daniels6 1Ziering Medical, Marbella, Spain; 2Ziering Medical, Los Angeles, CA, USA; 3The Hospital Group, Bromsgrove, Worcestershire, 4Ziering Medical, Birmingham, 5Ziering Medical, London, UK; 6Kerastem Technologies, San Diego, CA, USA Abstract: Great interest remains in finding new and emerging therapies for the treatment of male and female pattern hair loss. The autologous fat grafting technique is >100 years old, with a recent and dramatic increase in clinical experience over the past 10–15 years. Recently, in 2001, Zuk et al published the presence of adipose-derived stem cells, and abundant research has shown that adipose is a complex, biological active, and important tissue. Festa et al, in 2011, reported that adipocyte lineage cells support the stem cell niche and help drive the complex hair growth cycle. Adipose-derived regenerative cells (also known as stromal vascular fraction [SVF]) is a heterogeneous group of noncultured cells that can be reliably extracted from adipose by using automated systems, and these cells work largely by paracrine mechanisms to support adipocyte viability. While, today, autologous fat is transplanted primarily for esthetic and reconstructive volume, surgeons have previously reported positive skin and hair changes posttransplantation. This follicular regenerative approach is intriguing and raises the possibility that one can drive or restore the hair cycle in male and female pattern baldness by stimulating the niche with autologous fat enriched with SVF. In this first of a kind patient series, the authors report on the safety, tolerability, and quantitative, as well as photographic changes, in a group of patients with early genetic alopecia treated with subcutaneous scalp injection of enriched adipose tissue. The findings suggest that scalp stem cell-enriched fat grafting may represent a promising alternative approach to treating baldness in men and women. Keywords: stem cell, alopecia, adipose, stromal vascular fraction, transplantation
format	article
author	Perez-Meza D Ziering C Sforza M Krishnan G Ball E Daniels E
author_facet	Perez-Meza D Ziering C Sforza M Krishnan G Ball E Daniels E
author_sort	Perez-Meza D
title	Hair follicle growth by stromal vascular fraction-enhanced adipose transplantation in baldness
title_short	Hair follicle growth by stromal vascular fraction-enhanced adipose transplantation in baldness
title_full	Hair follicle growth by stromal vascular fraction-enhanced adipose transplantation in baldness
title_fullStr	Hair follicle growth by stromal vascular fraction-enhanced adipose transplantation in baldness
title_full_unstemmed	Hair follicle growth by stromal vascular fraction-enhanced adipose transplantation in baldness
title_sort	hair follicle growth by stromal vascular fraction-enhanced adipose transplantation in baldness
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/a484e7d1e7404ebbb034fe1a84bd64ec
work_keys_str_mv	AT perezmezad hairfolliclegrowthbystromalvascularfractionenhancedadiposetransplantationinbaldness AT zieringc hairfolliclegrowthbystromalvascularfractionenhancedadiposetransplantationinbaldness AT sforzam hairfolliclegrowthbystromalvascularfractionenhancedadiposetransplantationinbaldness AT krishnang hairfolliclegrowthbystromalvascularfractionenhancedadiposetransplantationinbaldness AT balle hairfolliclegrowthbystromalvascularfractionenhancedadiposetransplantationinbaldness AT danielse hairfolliclegrowthbystromalvascularfractionenhancedadiposetransplantationinbaldness
_version_	1718399593721364480

Hair follicle growth by stromal vascular fraction-enhanced adipose transplantation in baldness

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