Immediate effect of intravitreal injection of bevacizumab on intraocular pressure

Ricardo Lemos-Reis,1 Nuno Moreira-Gonçalves,1 António B Melo,1 Ângela M Carneiro,1,2 Fernando M Falcão-Reis1,2 1Department of Ophthalmology of Hospital de São João, Porto, Portugal; 2Department of Sense Organs, Faculty of Medicine, U...

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Autores principales:	Lemos-Reis R, Moreira-Gonçalves N, Melo AB, Carneiro AM, Falcão-Reis FM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/a485b1e99cc84eabab0b57a88de8f467
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spelling	oai:doaj.org-article:a485b1e99cc84eabab0b57a88de8f4672021-12-02T02:40:24ZImmediate effect of intravitreal injection of bevacizumab on intraocular pressure1177-5483https://doaj.org/article/a485b1e99cc84eabab0b57a88de8f4672014-07-01T00:00:00Zhttp://www.dovepress.com/immediate-effect-of-intravitreal-injection-of-bevacizumab-on-intraocul-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Ricardo Lemos-Reis,1 Nuno Moreira-Gonçalves,1 António B Melo,1 Ângela M Carneiro,1,2 Fernando M Falcão-Reis1,2 1Department of Ophthalmology of Hospital de São João, Porto, Portugal; 2Department of Sense Organs, Faculty of Medicine, University of Porto, Porto, Portugal Purpose: To investigate the immediate effect of intravitreal injection of bevacizumab on intraocular pressure (IOP). Methods: This was a prospective and nonrandomized study. A total of 291 eyes with macular edema or active choroidal neovascularization were submitted to a single 1.25 mg (0.05 mL) bevacizumab intravitreal injection. Intraocular pressure was measured with an Icare® tonometer immediately before and after injection in a seated position. The presence of subconjunctival reflux was recorded. The fellow eye served as the control.Results: Mean preoperative IOP was 18.0±5.9 mmHg in the treated eye versus 16.9±6.0 mmHg in the fellow eye. Mean postoperative IOP was 42.1±14.5 mmHg in the treated eye versus 17.5±6.0 mmHg in the fellow eye. The IOP variation was statistically significant in both cases and controls (P<0.001 and P=0.003, respectively), and this increase was higher in cases than in controls (P<0.001). Postoperative IOPs higher than 50 mmHg were achieved in 32.0% of the eyes. Subconjunctival reflux was present in 21.3% and determined a lower IOP rise (P<0.001). Tested variables (glaucoma, phakic status, and sex) did not have a statistically significant effect on IOP rise or subconjunctival reflux. Conclusion: IOP increases with intravitreal bevacizumab injection, reaching 50 mmHg or more in about one third of patients. A higher IOP is expected if no subconjunctival reflux occurs. The baseline IOP does not influence the incidence of subconjunctival reflux. The clinical relevance of these facts has yet to be clarified. Keywords: bevacizumab, intraocular pressure, intravitreal injection, Icare®Lemos-Reis RMoreira-Gonçalves NMelo ABCarneiro AMFalcão-Reis FMDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 1383-1388 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Lemos-Reis R Moreira-Gonçalves N Melo AB Carneiro AM Falcão-Reis FM Immediate effect of intravitreal injection of bevacizumab on intraocular pressure
description	Ricardo Lemos-Reis,1 Nuno Moreira-Gonçalves,1 António B Melo,1 Ângela M Carneiro,1,2 Fernando M Falcão-Reis1,2 1Department of Ophthalmology of Hospital de São João, Porto, Portugal; 2Department of Sense Organs, Faculty of Medicine, University of Porto, Porto, Portugal Purpose: To investigate the immediate effect of intravitreal injection of bevacizumab on intraocular pressure (IOP). Methods: This was a prospective and nonrandomized study. A total of 291 eyes with macular edema or active choroidal neovascularization were submitted to a single 1.25 mg (0.05 mL) bevacizumab intravitreal injection. Intraocular pressure was measured with an Icare® tonometer immediately before and after injection in a seated position. The presence of subconjunctival reflux was recorded. The fellow eye served as the control.Results: Mean preoperative IOP was 18.0±5.9 mmHg in the treated eye versus 16.9±6.0 mmHg in the fellow eye. Mean postoperative IOP was 42.1±14.5 mmHg in the treated eye versus 17.5±6.0 mmHg in the fellow eye. The IOP variation was statistically significant in both cases and controls (P<0.001 and P=0.003, respectively), and this increase was higher in cases than in controls (P<0.001). Postoperative IOPs higher than 50 mmHg were achieved in 32.0% of the eyes. Subconjunctival reflux was present in 21.3% and determined a lower IOP rise (P<0.001). Tested variables (glaucoma, phakic status, and sex) did not have a statistically significant effect on IOP rise or subconjunctival reflux. Conclusion: IOP increases with intravitreal bevacizumab injection, reaching 50 mmHg or more in about one third of patients. A higher IOP is expected if no subconjunctival reflux occurs. The baseline IOP does not influence the incidence of subconjunctival reflux. The clinical relevance of these facts has yet to be clarified. Keywords: bevacizumab, intraocular pressure, intravitreal injection, Icare®
format	article
author	Lemos-Reis R Moreira-Gonçalves N Melo AB Carneiro AM Falcão-Reis FM
author_facet	Lemos-Reis R Moreira-Gonçalves N Melo AB Carneiro AM Falcão-Reis FM
author_sort	Lemos-Reis R
title	Immediate effect of intravitreal injection of bevacizumab on intraocular pressure
title_short	Immediate effect of intravitreal injection of bevacizumab on intraocular pressure
title_full	Immediate effect of intravitreal injection of bevacizumab on intraocular pressure
title_fullStr	Immediate effect of intravitreal injection of bevacizumab on intraocular pressure
title_full_unstemmed	Immediate effect of intravitreal injection of bevacizumab on intraocular pressure
title_sort	immediate effect of intravitreal injection of bevacizumab on intraocular pressure
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/a485b1e99cc84eabab0b57a88de8f467
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Immediate effect of intravitreal injection of bevacizumab on intraocular pressure

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