Transcriptional expression of ZICs as an independent indicator of survival in gliomas

Abstract The functional significance of the zinc-finger of the cerebellum (ZIC) gene family in gliomas remains to be elucidated. Clinical data from patients with gliomas, containing expression levels of ZIC genes, were extracted from CCLE, GEPIA2 and The Human Protein Atlas (HPA). Univariate surviva...

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Autores principales:	Zhaocheng Han, Jingnan Jia, Yangting Lv, Rongyanqi Wang, Kegang Cao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a4861190fe11439985299b00ae00a7f2
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spelling	oai:doaj.org-article:a4861190fe11439985299b00ae00a7f22021-12-02T15:28:52ZTranscriptional expression of ZICs as an independent indicator of survival in gliomas10.1038/s41598-021-93877-32045-2322https://doaj.org/article/a4861190fe11439985299b00ae00a7f22021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93877-3https://doaj.org/toc/2045-2322Abstract The functional significance of the zinc-finger of the cerebellum (ZIC) gene family in gliomas remains to be elucidated. Clinical data from patients with gliomas, containing expression levels of ZIC genes, were extracted from CCLE, GEPIA2 and The Human Protein Atlas (HPA). Univariate survival analysis adjusted by Cox regression via OncoLnc was used to determine the prognostic significance of ZIC expression. We used cBioPortal to explore the correlation between gene mutations and overall survival (OS). ZIC expression was found to be related to immune cell infiltration in gliomas via TIMER analysis. GO term and KEGG pathway enrichment analyzes were performed with Metascape. PPI networks were constructed using STRING. The expression levels of ZIC1/3/4/5 in gliomas were significantly different from those in normal samples. High expression levels of ZIC1/5 were associated with poor OS in brain low-grade glioma (LGG) patients, while low ZIC3 expression combined was related to favorable OS in glioblastoma multiforme (GBM). ZIC alterations were associated with poor prognosis in LGG patients and related to favorable prognosis in GBM patients. We observed that the expression of ZICs was related to immune cell infiltration in glioma patients. ZICs were enriched in several pathways and biological processes involving Neuroactive ligand-receptor interaction (hsa04080). The PPI network revealed that some proteins coexpressed with ZICs played a role in the pathogenesis of gliomas. Differences in the expression levels of ZIC genes could provide a significant marker for predicting prognosis in gliomas.Zhaocheng HanJingnan JiaYangting LvRongyanqi WangKegang CaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhaocheng Han Jingnan Jia Yangting Lv Rongyanqi Wang Kegang Cao Transcriptional expression of ZICs as an independent indicator of survival in gliomas
description	Abstract The functional significance of the zinc-finger of the cerebellum (ZIC) gene family in gliomas remains to be elucidated. Clinical data from patients with gliomas, containing expression levels of ZIC genes, were extracted from CCLE, GEPIA2 and The Human Protein Atlas (HPA). Univariate survival analysis adjusted by Cox regression via OncoLnc was used to determine the prognostic significance of ZIC expression. We used cBioPortal to explore the correlation between gene mutations and overall survival (OS). ZIC expression was found to be related to immune cell infiltration in gliomas via TIMER analysis. GO term and KEGG pathway enrichment analyzes were performed with Metascape. PPI networks were constructed using STRING. The expression levels of ZIC1/3/4/5 in gliomas were significantly different from those in normal samples. High expression levels of ZIC1/5 were associated with poor OS in brain low-grade glioma (LGG) patients, while low ZIC3 expression combined was related to favorable OS in glioblastoma multiforme (GBM). ZIC alterations were associated with poor prognosis in LGG patients and related to favorable prognosis in GBM patients. We observed that the expression of ZICs was related to immune cell infiltration in glioma patients. ZICs were enriched in several pathways and biological processes involving Neuroactive ligand-receptor interaction (hsa04080). The PPI network revealed that some proteins coexpressed with ZICs played a role in the pathogenesis of gliomas. Differences in the expression levels of ZIC genes could provide a significant marker for predicting prognosis in gliomas.
format	article
author	Zhaocheng Han Jingnan Jia Yangting Lv Rongyanqi Wang Kegang Cao
author_facet	Zhaocheng Han Jingnan Jia Yangting Lv Rongyanqi Wang Kegang Cao
author_sort	Zhaocheng Han
title	Transcriptional expression of ZICs as an independent indicator of survival in gliomas
title_short	Transcriptional expression of ZICs as an independent indicator of survival in gliomas
title_full	Transcriptional expression of ZICs as an independent indicator of survival in gliomas
title_fullStr	Transcriptional expression of ZICs as an independent indicator of survival in gliomas
title_full_unstemmed	Transcriptional expression of ZICs as an independent indicator of survival in gliomas
title_sort	transcriptional expression of zics as an independent indicator of survival in gliomas
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a4861190fe11439985299b00ae00a7f2
work_keys_str_mv	AT zhaochenghan transcriptionalexpressionofzicsasanindependentindicatorofsurvivalingliomas AT jingnanjia transcriptionalexpressionofzicsasanindependentindicatorofsurvivalingliomas AT yangtinglv transcriptionalexpressionofzicsasanindependentindicatorofsurvivalingliomas AT rongyanqiwang transcriptionalexpressionofzicsasanindependentindicatorofsurvivalingliomas AT kegangcao transcriptionalexpressionofzicsasanindependentindicatorofsurvivalingliomas
_version_	1718387221259616256

Transcriptional expression of ZICs as an independent indicator of survival in gliomas

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