Learned Representation of Implied Serial Order in Posterior Parietal Cortex

Abstract Monkeys can learn the implied ranking of pairs of images drawn from an ordered set, despite never seeing all of the images simultaneously and without explicit spatial or temporal cues. We recorded the activity of posterior parietal cortex (including lateral intraparietal area LIP) neurons w...

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Autores principales:	Fabian Munoz, Greg Jensen, Benjamin C. Kennedy, Yelda Alkan, Herbert S. Terrace, Vincent P. Ferrera
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a4861d140bbf4e0dbe407237efcafe47
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spelling	oai:doaj.org-article:a4861d140bbf4e0dbe407237efcafe472021-12-02T17:52:24ZLearned Representation of Implied Serial Order in Posterior Parietal Cortex10.1038/s41598-020-65838-92045-2322https://doaj.org/article/a4861d140bbf4e0dbe407237efcafe472020-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-65838-9https://doaj.org/toc/2045-2322Abstract Monkeys can learn the implied ranking of pairs of images drawn from an ordered set, despite never seeing all of the images simultaneously and without explicit spatial or temporal cues. We recorded the activity of posterior parietal cortex (including lateral intraparietal area LIP) neurons while monkeys learned 7-item transitive inference (TI) lists with 2 items presented on each trial. Behavior and neuronal activity were significantly influenced by the ordinal relationship of the stimulus pairs, specifically symbolic distance (the difference in rank) and joint rank (the sum of the ranks). Symbolic distance strongly predicted decision accuracy and learning rate. An effect of joint rank on performance was found nested within the symbolic distance effect. Across the population of neurons, there was significant modulation of firing correlated with the relative ranks of the two stimuli presented on each trial. Neurons exhibited selectivity for stimulus rank during learning, but not before or after. The observed behavior is poorly explained by associative or reward mechanisms, and appears more consistent with a mental workspace model in which implied serial order is mapped within a spatial framework. The neural data suggest that posterior parietal cortex supports serial learning by representing information about the ordinal relationship of the stimuli presented during a given trial.Fabian MunozGreg JensenBenjamin C. KennedyYelda AlkanHerbert S. TerraceVincent P. FerreraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fabian Munoz Greg Jensen Benjamin C. Kennedy Yelda Alkan Herbert S. Terrace Vincent P. Ferrera Learned Representation of Implied Serial Order in Posterior Parietal Cortex
description	Abstract Monkeys can learn the implied ranking of pairs of images drawn from an ordered set, despite never seeing all of the images simultaneously and without explicit spatial or temporal cues. We recorded the activity of posterior parietal cortex (including lateral intraparietal area LIP) neurons while monkeys learned 7-item transitive inference (TI) lists with 2 items presented on each trial. Behavior and neuronal activity were significantly influenced by the ordinal relationship of the stimulus pairs, specifically symbolic distance (the difference in rank) and joint rank (the sum of the ranks). Symbolic distance strongly predicted decision accuracy and learning rate. An effect of joint rank on performance was found nested within the symbolic distance effect. Across the population of neurons, there was significant modulation of firing correlated with the relative ranks of the two stimuli presented on each trial. Neurons exhibited selectivity for stimulus rank during learning, but not before or after. The observed behavior is poorly explained by associative or reward mechanisms, and appears more consistent with a mental workspace model in which implied serial order is mapped within a spatial framework. The neural data suggest that posterior parietal cortex supports serial learning by representing information about the ordinal relationship of the stimuli presented during a given trial.
format	article
author	Fabian Munoz Greg Jensen Benjamin C. Kennedy Yelda Alkan Herbert S. Terrace Vincent P. Ferrera
author_facet	Fabian Munoz Greg Jensen Benjamin C. Kennedy Yelda Alkan Herbert S. Terrace Vincent P. Ferrera
author_sort	Fabian Munoz
title	Learned Representation of Implied Serial Order in Posterior Parietal Cortex
title_short	Learned Representation of Implied Serial Order in Posterior Parietal Cortex
title_full	Learned Representation of Implied Serial Order in Posterior Parietal Cortex
title_fullStr	Learned Representation of Implied Serial Order in Posterior Parietal Cortex
title_full_unstemmed	Learned Representation of Implied Serial Order in Posterior Parietal Cortex
title_sort	learned representation of implied serial order in posterior parietal cortex
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a4861d140bbf4e0dbe407237efcafe47
work_keys_str_mv	AT fabianmunoz learnedrepresentationofimpliedserialorderinposteriorparietalcortex AT gregjensen learnedrepresentationofimpliedserialorderinposteriorparietalcortex AT benjaminckennedy learnedrepresentationofimpliedserialorderinposteriorparietalcortex AT yeldaalkan learnedrepresentationofimpliedserialorderinposteriorparietalcortex AT herbertsterrace learnedrepresentationofimpliedserialorderinposteriorparietalcortex AT vincentpferrera learnedrepresentationofimpliedserialorderinposteriorparietalcortex
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Learned Representation of Implied Serial Order in Posterior Parietal Cortex

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