Urinary equol levels are positively associated with urinary estradiol excretion in women

Abstract Isoflavones found in soy products are a promising class of nutrients that may have a positive effect on human health. In particular, the phytoestrogen metabolite equol is associated with a reduced risk of developing female hormone-related diseases. However, the effect of equol on estrogen r...

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Autores principales:	Tomoko Fujitani, Yukiko Fujii, Zhaoqing Lyu, Mariko Harada Sassa, Kouji H. Harada
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a4863bb84aea4f3d9b6f1ae2227c98d2
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spelling	oai:doaj.org-article:a4863bb84aea4f3d9b6f1ae2227c98d22021-12-02T18:51:35ZUrinary equol levels are positively associated with urinary estradiol excretion in women10.1038/s41598-021-98872-22045-2322https://doaj.org/article/a4863bb84aea4f3d9b6f1ae2227c98d22021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98872-2https://doaj.org/toc/2045-2322Abstract Isoflavones found in soy products are a promising class of nutrients that may have a positive effect on human health. In particular, the phytoestrogen metabolite equol is associated with a reduced risk of developing female hormone-related diseases. However, the effect of equol on estrogen remains unclear. Equol can modify blood and urinary estradiol (E2) levels. The aim of this cross-sectional study was to examine the associations between urinary estrogen levels, equol levels, and equol production status in Japanese women. We analyzed urine samples from 520 women by gas chromatography-mass spectrometry. Urinary E2 and 4-hydroxylated E2 levels were higher in equol producers (EQP) than in non-EQPs (P < 0.0001 and P=0.00112, respectively). After adjusting for age and tobacco use by analysis of covariance, the association remained significant (β = 0.299, P < 0.0001). Analysis of covariance demonstrated that equol levels in urine were also positively associated with urinary E2 (β = 0.597, P < 0.0001). The log equol concentration showed a significant, but moderate, negative association with the serum E2 concentration (β = − 0.0225, P = 0.0462). Our findings suggest that equol may promote urinary E2 excretion and modify blood E2 levels in women.Tomoko FujitaniYukiko FujiiZhaoqing LyuMariko Harada SassaKouji H. HaradaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomoko Fujitani Yukiko Fujii Zhaoqing Lyu Mariko Harada Sassa Kouji H. Harada Urinary equol levels are positively associated with urinary estradiol excretion in women
description	Abstract Isoflavones found in soy products are a promising class of nutrients that may have a positive effect on human health. In particular, the phytoestrogen metabolite equol is associated with a reduced risk of developing female hormone-related diseases. However, the effect of equol on estrogen remains unclear. Equol can modify blood and urinary estradiol (E2) levels. The aim of this cross-sectional study was to examine the associations between urinary estrogen levels, equol levels, and equol production status in Japanese women. We analyzed urine samples from 520 women by gas chromatography-mass spectrometry. Urinary E2 and 4-hydroxylated E2 levels were higher in equol producers (EQP) than in non-EQPs (P < 0.0001 and P=0.00112, respectively). After adjusting for age and tobacco use by analysis of covariance, the association remained significant (β = 0.299, P < 0.0001). Analysis of covariance demonstrated that equol levels in urine were also positively associated with urinary E2 (β = 0.597, P < 0.0001). The log equol concentration showed a significant, but moderate, negative association with the serum E2 concentration (β = − 0.0225, P = 0.0462). Our findings suggest that equol may promote urinary E2 excretion and modify blood E2 levels in women.
format	article
author	Tomoko Fujitani Yukiko Fujii Zhaoqing Lyu Mariko Harada Sassa Kouji H. Harada
author_facet	Tomoko Fujitani Yukiko Fujii Zhaoqing Lyu Mariko Harada Sassa Kouji H. Harada
author_sort	Tomoko Fujitani
title	Urinary equol levels are positively associated with urinary estradiol excretion in women
title_short	Urinary equol levels are positively associated with urinary estradiol excretion in women
title_full	Urinary equol levels are positively associated with urinary estradiol excretion in women
title_fullStr	Urinary equol levels are positively associated with urinary estradiol excretion in women
title_full_unstemmed	Urinary equol levels are positively associated with urinary estradiol excretion in women
title_sort	urinary equol levels are positively associated with urinary estradiol excretion in women
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a4863bb84aea4f3d9b6f1ae2227c98d2
work_keys_str_mv	AT tomokofujitani urinaryequollevelsarepositivelyassociatedwithurinaryestradiolexcretioninwomen AT yukikofujii urinaryequollevelsarepositivelyassociatedwithurinaryestradiolexcretioninwomen AT zhaoqinglyu urinaryequollevelsarepositivelyassociatedwithurinaryestradiolexcretioninwomen AT marikoharadasassa urinaryequollevelsarepositivelyassociatedwithurinaryestradiolexcretioninwomen AT koujihharada urinaryequollevelsarepositivelyassociatedwithurinaryestradiolexcretioninwomen
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Urinary equol levels are positively associated with urinary estradiol excretion in women

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