Longitudinal analysis of premotor anthropometric and serological markers of Parkinson’s disease

Abstract Parkinson’s disease (PD) is a debilitating neurodegenerative disorder in which nonmotor symptoms, such as constipation and hyposmia, precede the onset of motor symptoms by 20 years. The aim of this study was to identify biomarkers at the premotor stage of PD. We assessed the differences in...

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Autores principales:	Katsunori Yokoi, Makoto Hattori, Yuki Satake, Yasuhiro Tanaka, Maki Sato, Atsushi Hashizume, Akihiro Hori, Motoshi Kawashima, Akihiro Hirakawa, Hirohisa Watanabe, Masahisa Katsuno
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a48ab8e8097144e7b966d67d9ef7b238
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spelling	oai:doaj.org-article:a48ab8e8097144e7b966d67d9ef7b2382021-12-02T12:34:18ZLongitudinal analysis of premotor anthropometric and serological markers of Parkinson’s disease10.1038/s41598-020-77415-12045-2322https://doaj.org/article/a48ab8e8097144e7b966d67d9ef7b2382020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77415-1https://doaj.org/toc/2045-2322Abstract Parkinson’s disease (PD) is a debilitating neurodegenerative disorder in which nonmotor symptoms, such as constipation and hyposmia, precede the onset of motor symptoms by 20 years. The aim of this study was to identify biomarkers at the premotor stage of PD. We assessed the differences in longitudinal changes in anthropometric and serological indices obtained from health check-up data before and after the onset of motor symptoms between male and female PD patients and healthy subjects. We enrolled 22 male and 23 female PD patients and 60 male and 60 female healthy controls. A mixed-effects model was used to estimate the trajectory of each clinical marker over the years before and after motor symptoms onset in the PD subjects, which were then compared with the trajectories of the healthy controls. The results showed a premotor blood pressure increase in female PD patients and premotor decreases in haematocrit, total cholesterol and low-density lipoprotein cholesterol in the male patients. Our results indicated that blood pressure, haematocrit and serum cholesterol levels are potential premotor markers of PD. Additionally, the changes in anthropometric and serological indices before PD motor symptoms onset were sex specific.Katsunori YokoiMakoto HattoriYuki SatakeYasuhiro TanakaMaki SatoAtsushi HashizumeAkihiro HoriMotoshi KawashimaAkihiro HirakawaHirohisa WatanabeMasahisa KatsunoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Katsunori Yokoi Makoto Hattori Yuki Satake Yasuhiro Tanaka Maki Sato Atsushi Hashizume Akihiro Hori Motoshi Kawashima Akihiro Hirakawa Hirohisa Watanabe Masahisa Katsuno Longitudinal analysis of premotor anthropometric and serological markers of Parkinson’s disease
description	Abstract Parkinson’s disease (PD) is a debilitating neurodegenerative disorder in which nonmotor symptoms, such as constipation and hyposmia, precede the onset of motor symptoms by 20 years. The aim of this study was to identify biomarkers at the premotor stage of PD. We assessed the differences in longitudinal changes in anthropometric and serological indices obtained from health check-up data before and after the onset of motor symptoms between male and female PD patients and healthy subjects. We enrolled 22 male and 23 female PD patients and 60 male and 60 female healthy controls. A mixed-effects model was used to estimate the trajectory of each clinical marker over the years before and after motor symptoms onset in the PD subjects, which were then compared with the trajectories of the healthy controls. The results showed a premotor blood pressure increase in female PD patients and premotor decreases in haematocrit, total cholesterol and low-density lipoprotein cholesterol in the male patients. Our results indicated that blood pressure, haematocrit and serum cholesterol levels are potential premotor markers of PD. Additionally, the changes in anthropometric and serological indices before PD motor symptoms onset were sex specific.
format	article
author	Katsunori Yokoi Makoto Hattori Yuki Satake Yasuhiro Tanaka Maki Sato Atsushi Hashizume Akihiro Hori Motoshi Kawashima Akihiro Hirakawa Hirohisa Watanabe Masahisa Katsuno
author_facet	Katsunori Yokoi Makoto Hattori Yuki Satake Yasuhiro Tanaka Maki Sato Atsushi Hashizume Akihiro Hori Motoshi Kawashima Akihiro Hirakawa Hirohisa Watanabe Masahisa Katsuno
author_sort	Katsunori Yokoi
title	Longitudinal analysis of premotor anthropometric and serological markers of Parkinson’s disease
title_short	Longitudinal analysis of premotor anthropometric and serological markers of Parkinson’s disease
title_full	Longitudinal analysis of premotor anthropometric and serological markers of Parkinson’s disease
title_fullStr	Longitudinal analysis of premotor anthropometric and serological markers of Parkinson’s disease
title_full_unstemmed	Longitudinal analysis of premotor anthropometric and serological markers of Parkinson’s disease
title_sort	longitudinal analysis of premotor anthropometric and serological markers of parkinson’s disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a48ab8e8097144e7b966d67d9ef7b238
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Longitudinal analysis of premotor anthropometric and serological markers of Parkinson’s disease

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