Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles

An effective vaccine for human papillomavirus (HPV) needs to protect from several genotypes. Here, Wang et al. provide a strategy to produce single capsomere-hybrid virus-like particle (chVLP) composed of capsomers of different genotypes and show that a nona-type chVLP induces similar levels of neut...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Daning Wang, Xinlin Liu, Minxi Wei, Ciying Qian, Shuo Song, Jie Chen, Zhiping Wang, Qin Xu, Yurou Yang, Maozhou He, Xin Chi, Shiwen Huang, Tingting Li, Zhibo Kong, Qingbing Zheng, Hai Yu, Yingbin Wang, Qinjian Zhao, Jun Zhang, Ningshao Xia, Ying Gu, Shaowei Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a48ad75cb64149f78c08387b5f6a5505
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a48ad75cb64149f78c08387b5f6a5505
record_format	dspace
spelling	oai:doaj.org-article:a48ad75cb64149f78c08387b5f6a55052021-12-02T15:57:09ZRational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles10.1038/s41467-020-16639-12041-1723https://doaj.org/article/a48ad75cb64149f78c08387b5f6a55052020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16639-1https://doaj.org/toc/2041-1723An effective vaccine for human papillomavirus (HPV) needs to protect from several genotypes. Here, Wang et al. provide a strategy to produce single capsomere-hybrid virus-like particle (chVLP) composed of capsomers of different genotypes and show that a nona-type chVLP induces similar levels of neutralizing antibodies as an approved HPV vaccine.Daning WangXinlin LiuMinxi WeiCiying QianShuo SongJie ChenZhiping WangQin XuYurou YangMaozhou HeXin ChiShiwen HuangTingting LiZhibo KongQingbing ZhengHai YuYingbin WangQinjian ZhaoJun ZhangNingshao XiaYing GuShaowei LiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daning Wang Xinlin Liu Minxi Wei Ciying Qian Shuo Song Jie Chen Zhiping Wang Qin Xu Yurou Yang Maozhou He Xin Chi Shiwen Huang Tingting Li Zhibo Kong Qingbing Zheng Hai Yu Yingbin Wang Qinjian Zhao Jun Zhang Ningshao Xia Ying Gu Shaowei Li Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles
description	An effective vaccine for human papillomavirus (HPV) needs to protect from several genotypes. Here, Wang et al. provide a strategy to produce single capsomere-hybrid virus-like particle (chVLP) composed of capsomers of different genotypes and show that a nona-type chVLP induces similar levels of neutralizing antibodies as an approved HPV vaccine.
format	article
author	Daning Wang Xinlin Liu Minxi Wei Ciying Qian Shuo Song Jie Chen Zhiping Wang Qin Xu Yurou Yang Maozhou He Xin Chi Shiwen Huang Tingting Li Zhibo Kong Qingbing Zheng Hai Yu Yingbin Wang Qinjian Zhao Jun Zhang Ningshao Xia Ying Gu Shaowei Li
author_facet	Daning Wang Xinlin Liu Minxi Wei Ciying Qian Shuo Song Jie Chen Zhiping Wang Qin Xu Yurou Yang Maozhou He Xin Chi Shiwen Huang Tingting Li Zhibo Kong Qingbing Zheng Hai Yu Yingbin Wang Qinjian Zhao Jun Zhang Ningshao Xia Ying Gu Shaowei Li
author_sort	Daning Wang
title	Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles
title_short	Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles
title_full	Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles
title_fullStr	Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles
title_full_unstemmed	Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles
title_sort	rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a48ad75cb64149f78c08387b5f6a5505
work_keys_str_mv	AT daningwang rationaldesignofamultivalenthumanpapillomavirusvaccinebycapsomerehybridcoassemblyofviruslikeparticles AT xinlinliu rationaldesignofamultivalenthumanpapillomavirusvaccinebycapsomerehybridcoassemblyofviruslikeparticles AT minxiwei rationaldesignofamultivalenthumanpapillomavirusvaccinebycapsomerehybridcoassemblyofviruslikeparticles AT ciyingqian rationaldesignofamultivalenthumanpapillomavirusvaccinebycapsomerehybridcoassemblyofviruslikeparticles AT shuosong rationaldesignofamultivalenthumanpapillomavirusvaccinebycapsomerehybridcoassemblyofviruslikeparticles AT jiechen rationaldesignofamultivalenthumanpapillomavirusvaccinebycapsomerehybridcoassemblyofviruslikeparticles AT zhipingwang rationaldesignofamultivalenthumanpapillomavirusvaccinebycapsomerehybridcoassemblyofviruslikeparticles AT qinxu rationaldesignofamultivalenthumanpapillomavirusvaccinebycapsomerehybridcoassemblyofviruslikeparticles AT yurouyang rationaldesignofamultivalenthumanpapillomavirusvaccinebycapsomerehybridcoassemblyofviruslikeparticles AT maozhouhe rationaldesignofamultivalenthumanpapillomavirusvaccinebycapsomerehybridcoassemblyofviruslikeparticles AT xinchi rationaldesignofamultivalenthumanpapillomavirusvaccinebycapsomerehybridcoassemblyofviruslikeparticles AT shiwenhuang rationaldesignofamultivalenthumanpapillomavirusvaccinebycapsomerehybridcoassemblyofviruslikeparticles AT tingtingli rationaldesignofamultivalenthumanpapillomavirusvaccinebycapsomerehybridcoassemblyofviruslikeparticles AT zhibokong rationaldesignofamultivalenthumanpapillomavirusvaccinebycapsomerehybridcoassemblyofviruslikeparticles AT qingbingzheng rationaldesignofamultivalenthumanpapillomavirusvaccinebycapsomerehybridcoassemblyofviruslikeparticles AT haiyu rationaldesignofamultivalenthumanpapillomavirusvaccinebycapsomerehybridcoassemblyofviruslikeparticles AT yingbinwang rationaldesignofamultivalenthumanpapillomavirusvaccinebycapsomerehybridcoassemblyofviruslikeparticles AT qinjianzhao rationaldesignofamultivalenthumanpapillomavirusvaccinebycapsomerehybridcoassemblyofviruslikeparticles AT junzhang rationaldesignofamultivalenthumanpapillomavirusvaccinebycapsomerehybridcoassemblyofviruslikeparticles AT ningshaoxia rationaldesignofamultivalenthumanpapillomavirusvaccinebycapsomerehybridcoassemblyofviruslikeparticles AT yinggu rationaldesignofamultivalenthumanpapillomavirusvaccinebycapsomerehybridcoassemblyofviruslikeparticles AT shaoweili rationaldesignofamultivalenthumanpapillomavirusvaccinebycapsomerehybridcoassemblyofviruslikeparticles
_version_	1718385346198110208

Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles

Ejemplares similares