Clinical utility of neurostimulation devices in the treatment of overactive bladder: current perspectives

Dick AW Janssen,1 Frank MJ Martens,1 Liesbeth L de Wall,1 Hendrikje MK van Breda,2 John PFA Heesakkers1 1Department of Urology, Radboud University Nijmegen Medical Center, Nijmegen, 2Department of Urology, University Medical Center Utrecht, Utrecht, the Netherlands Objectives: This review describes...

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Autores principales:	Janssen DAW, Martens FMJ, de Wall LL, van Breda HMK, Heesakkers JPFA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	neuromodulation bladder sacral nerve stimulation sacral anterior root stimulation PTNS implant. Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/a48bb2c792484c279b7b905314ab74f7
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spelling	oai:doaj.org-article:a48bb2c792484c279b7b905314ab74f72021-12-02T00:04:05ZClinical utility of neurostimulation devices in the treatment of overactive bladder: current perspectives1179-1470https://doaj.org/article/a48bb2c792484c279b7b905314ab74f72017-06-01T00:00:00Zhttps://www.dovepress.com/clinical-utility-of-neurostimulation-devices-in-the-treatment-of-overa-peer-reviewed-article-MDERhttps://doaj.org/toc/1179-1470Dick AW Janssen,1 Frank MJ Martens,1 Liesbeth L de Wall,1 Hendrikje MK van Breda,2 John PFA Heesakkers1 1Department of Urology, Radboud University Nijmegen Medical Center, Nijmegen, 2Department of Urology, University Medical Center Utrecht, Utrecht, the Netherlands Objectives: This review describes the evidence from established and experimental therapies that use electrical nerve stimulation to treat lower urinary tract dysfunction.Methods: Clinical studies on established treatments such as percutaneous posterior tibial nerve stimulation (P-PTNS), transcutaneous electrical nerve stimulation (TENS), sacral nerve stimulation (SNS) and sacral anterior root stimulation (SARS) are evaluated. In addition, clinical evidence from experimental therapies such as dorsal genital nerve (DGN) stimulation, pudendal nerve stimulation, magnetic nerve stimulation and ankle implants for tibial nerve stimulation are evaluated.Results: SNS and P-PTNS have been investigated with high-quality studies that have shown proven efficacy for the treatment for overactive bladder (OAB). SARS has proven evidence-based efficacy in spinal cord patients and increases the quality of life. TENS seems inferior to other OAB treatments such as SNS and P-PTNS but is noninvasive and applicable for ambulant therapy. Results from studies on experimental therapies such as pudendal nerve stimulation seem promising but need larger study cohorts to prove efficacy.Conclusion: Neurostimulation therapies have proven efficacy for bladder dysfunction in patients who are refractory to other therapies.Significance: Refinement of neurostimulation therapies is possible. The aim should be to make the treatments less invasive, more durable and more effective for the treatment of lower urinary tract dysfunction. Keywords: neuromodulation, overactive bladder syndrome, sacral nerve stimulation, sacral anterior root stimulation, PTNS, implantJanssen DAWMartens FMJde Wall LLvan Breda HMKHeesakkers JPFADove Medical Pressarticleneuromodulationbladdersacral nerve stimulationsacral anterior root stimulationPTNSimplant.Medical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol Volume 10, Pp 109-122 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	neuromodulation bladder sacral nerve stimulation sacral anterior root stimulation PTNS implant. Medical technology R855-855.5
spellingShingle	neuromodulation bladder sacral nerve stimulation sacral anterior root stimulation PTNS implant. Medical technology R855-855.5 Janssen DAW Martens FMJ de Wall LL van Breda HMK Heesakkers JPFA Clinical utility of neurostimulation devices in the treatment of overactive bladder: current perspectives
description	Dick AW Janssen,1 Frank MJ Martens,1 Liesbeth L de Wall,1 Hendrikje MK van Breda,2 John PFA Heesakkers1 1Department of Urology, Radboud University Nijmegen Medical Center, Nijmegen, 2Department of Urology, University Medical Center Utrecht, Utrecht, the Netherlands Objectives: This review describes the evidence from established and experimental therapies that use electrical nerve stimulation to treat lower urinary tract dysfunction.Methods: Clinical studies on established treatments such as percutaneous posterior tibial nerve stimulation (P-PTNS), transcutaneous electrical nerve stimulation (TENS), sacral nerve stimulation (SNS) and sacral anterior root stimulation (SARS) are evaluated. In addition, clinical evidence from experimental therapies such as dorsal genital nerve (DGN) stimulation, pudendal nerve stimulation, magnetic nerve stimulation and ankle implants for tibial nerve stimulation are evaluated.Results: SNS and P-PTNS have been investigated with high-quality studies that have shown proven efficacy for the treatment for overactive bladder (OAB). SARS has proven evidence-based efficacy in spinal cord patients and increases the quality of life. TENS seems inferior to other OAB treatments such as SNS and P-PTNS but is noninvasive and applicable for ambulant therapy. Results from studies on experimental therapies such as pudendal nerve stimulation seem promising but need larger study cohorts to prove efficacy.Conclusion: Neurostimulation therapies have proven efficacy for bladder dysfunction in patients who are refractory to other therapies.Significance: Refinement of neurostimulation therapies is possible. The aim should be to make the treatments less invasive, more durable and more effective for the treatment of lower urinary tract dysfunction. Keywords: neuromodulation, overactive bladder syndrome, sacral nerve stimulation, sacral anterior root stimulation, PTNS, implant
format	article
author	Janssen DAW Martens FMJ de Wall LL van Breda HMK Heesakkers JPFA
author_facet	Janssen DAW Martens FMJ de Wall LL van Breda HMK Heesakkers JPFA
author_sort	Janssen DAW
title	Clinical utility of neurostimulation devices in the treatment of overactive bladder: current perspectives
title_short	Clinical utility of neurostimulation devices in the treatment of overactive bladder: current perspectives
title_full	Clinical utility of neurostimulation devices in the treatment of overactive bladder: current perspectives
title_fullStr	Clinical utility of neurostimulation devices in the treatment of overactive bladder: current perspectives
title_full_unstemmed	Clinical utility of neurostimulation devices in the treatment of overactive bladder: current perspectives
title_sort	clinical utility of neurostimulation devices in the treatment of overactive bladder: current perspectives
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/a48bb2c792484c279b7b905314ab74f7
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Clinical utility of neurostimulation devices in the treatment of overactive bladder: current perspectives

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