Comparison of mitral regurgitation severity assessments based on magnetic resonance imaging and echocardiography in patients with hypertrophic cardiomyopathy

Abstract Mitral regurgitation (MR), which is one of the factors responsible for heart failure symptoms and the development of atrial fibrillation, is an important feature of hypertrophic cardiomyopathy (HCM), and its presence affects which treatment options are chosen. Although cardiac magnetic reso...

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Autores principales:	Mateusz Śpiewak, Mariusz Kłopotowski, Ewa Kowalik, Łukasz Mazurkiewicz, Katarzyna Kożuch, Joanna Petryka-Mazurkiewicz, Barbara Miłosz-Wieczorek, Adam Witkowski, Anna Klisiewicz, Magdalena Marczak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a48e5b0d6a6348328791aa59cee14421
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spelling	oai:doaj.org-article:a48e5b0d6a6348328791aa59cee144212021-12-02T18:01:40ZComparison of mitral regurgitation severity assessments based on magnetic resonance imaging and echocardiography in patients with hypertrophic cardiomyopathy10.1038/s41598-021-99446-y2045-2322https://doaj.org/article/a48e5b0d6a6348328791aa59cee144212021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99446-yhttps://doaj.org/toc/2045-2322Abstract Mitral regurgitation (MR), which is one of the factors responsible for heart failure symptoms and the development of atrial fibrillation, is an important feature of hypertrophic cardiomyopathy (HCM), and its presence affects which treatment options are chosen. Although cardiac magnetic resonance imaging (MRI) is considered the reference standard for assessing the regurgitant volume (RV) and fraction (RF), echocardiography is the most common method for assessing MR severity. Accordingly, the aim of this study was to compare the results of echocardiography and cardiac MRI for assessing MR severity in a cohort of patients with HCM. MR severity was assessed in 53 patients using cardiac MRI by determining the mitral RV (MRV) and mitral RF (MRF). The results were graded according to thresholds recommended in current guidelines. MR severity assessed by echocardiography was graded by integrating indices of severity. Greater than mild MR, as assessed using echocardiography, was present in 22 patients (41.5%) with HCM and in none of the control patients (p = 0.001). In all, 31 patients (58.5%) had no more than mild MR. When MR severity was assessed using different methods, either moderate (kappa = 0.44, 95% confidence interval = 0.21–0.67), poor or no agreement was found between MRI-derived and echocardiography-derived grades. HCM patients with echocardiography-derived moderate and severe MR had similar median MRVs and MRFs (p = 0.59 and p = 0.11, respectively). In HCM patients, cardiac MRI and echocardiography were at most in modest agreement in assessing MR severity. Importantly, echocardiography-derived moderate and severe MR were not distinguishable by either MRV or MRF.Mateusz ŚpiewakMariusz KłopotowskiEwa KowalikŁukasz MazurkiewiczKatarzyna KożuchJoanna Petryka-MazurkiewiczBarbara Miłosz-WieczorekAdam WitkowskiAnna KlisiewiczMagdalena MarczakNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mateusz Śpiewak Mariusz Kłopotowski Ewa Kowalik Łukasz Mazurkiewicz Katarzyna Kożuch Joanna Petryka-Mazurkiewicz Barbara Miłosz-Wieczorek Adam Witkowski Anna Klisiewicz Magdalena Marczak Comparison of mitral regurgitation severity assessments based on magnetic resonance imaging and echocardiography in patients with hypertrophic cardiomyopathy
description	Abstract Mitral regurgitation (MR), which is one of the factors responsible for heart failure symptoms and the development of atrial fibrillation, is an important feature of hypertrophic cardiomyopathy (HCM), and its presence affects which treatment options are chosen. Although cardiac magnetic resonance imaging (MRI) is considered the reference standard for assessing the regurgitant volume (RV) and fraction (RF), echocardiography is the most common method for assessing MR severity. Accordingly, the aim of this study was to compare the results of echocardiography and cardiac MRI for assessing MR severity in a cohort of patients with HCM. MR severity was assessed in 53 patients using cardiac MRI by determining the mitral RV (MRV) and mitral RF (MRF). The results were graded according to thresholds recommended in current guidelines. MR severity assessed by echocardiography was graded by integrating indices of severity. Greater than mild MR, as assessed using echocardiography, was present in 22 patients (41.5%) with HCM and in none of the control patients (p = 0.001). In all, 31 patients (58.5%) had no more than mild MR. When MR severity was assessed using different methods, either moderate (kappa = 0.44, 95% confidence interval = 0.21–0.67), poor or no agreement was found between MRI-derived and echocardiography-derived grades. HCM patients with echocardiography-derived moderate and severe MR had similar median MRVs and MRFs (p = 0.59 and p = 0.11, respectively). In HCM patients, cardiac MRI and echocardiography were at most in modest agreement in assessing MR severity. Importantly, echocardiography-derived moderate and severe MR were not distinguishable by either MRV or MRF.
format	article
author	Mateusz Śpiewak Mariusz Kłopotowski Ewa Kowalik Łukasz Mazurkiewicz Katarzyna Kożuch Joanna Petryka-Mazurkiewicz Barbara Miłosz-Wieczorek Adam Witkowski Anna Klisiewicz Magdalena Marczak
author_facet	Mateusz Śpiewak Mariusz Kłopotowski Ewa Kowalik Łukasz Mazurkiewicz Katarzyna Kożuch Joanna Petryka-Mazurkiewicz Barbara Miłosz-Wieczorek Adam Witkowski Anna Klisiewicz Magdalena Marczak
author_sort	Mateusz Śpiewak
title	Comparison of mitral regurgitation severity assessments based on magnetic resonance imaging and echocardiography in patients with hypertrophic cardiomyopathy
title_short	Comparison of mitral regurgitation severity assessments based on magnetic resonance imaging and echocardiography in patients with hypertrophic cardiomyopathy
title_full	Comparison of mitral regurgitation severity assessments based on magnetic resonance imaging and echocardiography in patients with hypertrophic cardiomyopathy
title_fullStr	Comparison of mitral regurgitation severity assessments based on magnetic resonance imaging and echocardiography in patients with hypertrophic cardiomyopathy
title_full_unstemmed	Comparison of mitral regurgitation severity assessments based on magnetic resonance imaging and echocardiography in patients with hypertrophic cardiomyopathy
title_sort	comparison of mitral regurgitation severity assessments based on magnetic resonance imaging and echocardiography in patients with hypertrophic cardiomyopathy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a48e5b0d6a6348328791aa59cee14421
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Comparison of mitral regurgitation severity assessments based on magnetic resonance imaging and echocardiography in patients with hypertrophic cardiomyopathy

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