Cerebral magnetic resonance imaging of coincidental infarction and small vessel disease in retinal artery occlusion

Abstract There are several reports in the literature on the association between non-arteritic retinal artery occlusion (NA-RAO) and acute ischemic stroke. We investigated the burden of small vessel disease (SVD) and cerebral coincident infarction observed on cerebral magnetic resonance imaging (MRI)...

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Autores principales:	Yong Dae Kim, Jun Yup Kim, Young Joo Park, Sang Jun Park, Sung Hyun Baik, Jihoon Kang, Cheolkyu Jung, Se Joon Woo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a48f728c8a50436da440d6ff6a092f34
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spelling	oai:doaj.org-article:a48f728c8a50436da440d6ff6a092f342021-12-02T14:01:21ZCerebral magnetic resonance imaging of coincidental infarction and small vessel disease in retinal artery occlusion10.1038/s41598-020-80014-92045-2322https://doaj.org/article/a48f728c8a50436da440d6ff6a092f342021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80014-9https://doaj.org/toc/2045-2322Abstract There are several reports in the literature on the association between non-arteritic retinal artery occlusion (NA-RAO) and acute ischemic stroke. We investigated the burden of small vessel disease (SVD) and cerebral coincident infarction observed on cerebral magnetic resonance imaging (MRI) in patients with newly diagnosed NA-RAO. In this retrospective, observational, case-series study, consecutive patients with NA-RAO who underwent cerebral MRI within one month of diagnosis between September 2003 and October 2018 were included. The classification of NA-RAO was based on ophthalmologic and systemic examinations. We also investigated the co-incident infarction and burden of underlying SVD, which were categorized as white matter hyperintensity lesion (WMH), cerebral microbleeds (CMB), and silent lacunar infarction (SLI). Among the 272 patients enrolled in the study, 18% presented co-incident infarction and 73% had SVD, which included WMH (70%), CMB (14%), and SLI (30%). Co-incident infarction, WMH, and SLI significantly increased with age: co-incident infarction was observed in 8% of young (< 50 years) patients and 30% of old (≥ 70 years) patients. The embolic etiology of RAO (large artery atherosclerosis, cardioembolism, and undetermined etiology) was significantly associated with the prevalence of SVD (82%: 70%: 64%, P = 0.002) and co-incident infarction (30%: 19%: 8%; P = 0.009). Therefore, high co-incidence of acute cerebral infarction and underlying SVD burden warrant careful neurologic examination and appropriate brain imaging, followed by management of NA-RAO. Urgent brain imaging is particularly pertinent in elderly patients with NA-RAO.Yong Dae KimJun Yup KimYoung Joo ParkSang Jun ParkSung Hyun BaikJihoon KangCheolkyu JungSe Joon WooNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yong Dae Kim Jun Yup Kim Young Joo Park Sang Jun Park Sung Hyun Baik Jihoon Kang Cheolkyu Jung Se Joon Woo Cerebral magnetic resonance imaging of coincidental infarction and small vessel disease in retinal artery occlusion
description	Abstract There are several reports in the literature on the association between non-arteritic retinal artery occlusion (NA-RAO) and acute ischemic stroke. We investigated the burden of small vessel disease (SVD) and cerebral coincident infarction observed on cerebral magnetic resonance imaging (MRI) in patients with newly diagnosed NA-RAO. In this retrospective, observational, case-series study, consecutive patients with NA-RAO who underwent cerebral MRI within one month of diagnosis between September 2003 and October 2018 were included. The classification of NA-RAO was based on ophthalmologic and systemic examinations. We also investigated the co-incident infarction and burden of underlying SVD, which were categorized as white matter hyperintensity lesion (WMH), cerebral microbleeds (CMB), and silent lacunar infarction (SLI). Among the 272 patients enrolled in the study, 18% presented co-incident infarction and 73% had SVD, which included WMH (70%), CMB (14%), and SLI (30%). Co-incident infarction, WMH, and SLI significantly increased with age: co-incident infarction was observed in 8% of young (< 50 years) patients and 30% of old (≥ 70 years) patients. The embolic etiology of RAO (large artery atherosclerosis, cardioembolism, and undetermined etiology) was significantly associated with the prevalence of SVD (82%: 70%: 64%, P = 0.002) and co-incident infarction (30%: 19%: 8%; P = 0.009). Therefore, high co-incidence of acute cerebral infarction and underlying SVD burden warrant careful neurologic examination and appropriate brain imaging, followed by management of NA-RAO. Urgent brain imaging is particularly pertinent in elderly patients with NA-RAO.
format	article
author	Yong Dae Kim Jun Yup Kim Young Joo Park Sang Jun Park Sung Hyun Baik Jihoon Kang Cheolkyu Jung Se Joon Woo
author_facet	Yong Dae Kim Jun Yup Kim Young Joo Park Sang Jun Park Sung Hyun Baik Jihoon Kang Cheolkyu Jung Se Joon Woo
author_sort	Yong Dae Kim
title	Cerebral magnetic resonance imaging of coincidental infarction and small vessel disease in retinal artery occlusion
title_short	Cerebral magnetic resonance imaging of coincidental infarction and small vessel disease in retinal artery occlusion
title_full	Cerebral magnetic resonance imaging of coincidental infarction and small vessel disease in retinal artery occlusion
title_fullStr	Cerebral magnetic resonance imaging of coincidental infarction and small vessel disease in retinal artery occlusion
title_full_unstemmed	Cerebral magnetic resonance imaging of coincidental infarction and small vessel disease in retinal artery occlusion
title_sort	cerebral magnetic resonance imaging of coincidental infarction and small vessel disease in retinal artery occlusion
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a48f728c8a50436da440d6ff6a092f34
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_version_	1718392218715160576

Cerebral magnetic resonance imaging of coincidental infarction and small vessel disease in retinal artery occlusion

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