The DOG 1 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF CHONDROBLASTOMAS AND ITS HISTOLOGICAL MIMICKERS
Objective: Chondroblastoma is rare benign cartilage forming tumor of bone predominantly in individuals less than 20 years of age. Recently immunohistochemical marker DOG 1 has been reported to help in the diagnosis in difficult cases where histological features overlap with other similar entities. C...
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Army Medical College Rawalpindi
2020
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oai:doaj.org-article:a492839beea3449ca51a5d7ade1fc3202021-11-04T02:36:35ZThe DOG 1 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF CHONDROBLASTOMAS AND ITS HISTOLOGICAL MIMICKERS0030-96482411-8842https://doaj.org/article/a492839beea3449ca51a5d7ade1fc3202020-12-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2533/3069https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: Chondroblastoma is rare benign cartilage forming tumor of bone predominantly in individuals less than 20 years of age. Recently immunohistochemical marker DOG 1 has been reported to help in the diagnosis in difficult cases where histological features overlap with other similar entities. Current study aims to assess the sensitivity and specificity of DOG 1 in the diagnosis of chondroblastomas. Study design: descriptive cross-sectional study Place and duration of study: The study was conducted from June 2015 to July 2017 in Department of Histopathology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan. Patients and methods: Total fifty-two patients were included in this study including 19 chondroblastomas, 21 giant cell tumors and 12 chondromyxoid fibromas. DOG 1 antibody was applied on all the cases Results: DOG 1 was positive in 100 % of cases of chondroblastomas. However, intensity and proportion of staining pattern was variable among them. 78% (n=15) cases showed diffuse moderate to strong expression while 22% (n=4) cases showed focal weak expression. Only 10% (n=2) cases of giant cell tumors and 33% (n=4) of chondromyxoid fibromas expressed focal weak expression for DOG 1. Conclusions: This study confirms 100 % expression of DOG 1 in cases of chondroblastomas but intensity and proportion of staining pattern was variable. Therefore DOG 1 may prove to be a useful immunohistochemical marker for diagnosis of chondroblastomas in the future in difficult cases in correlation with histological and radiological features.Maryam NisarSajid MushtaqUsman HassanNoreen AkhtarMuhammad AzamArmy Medical College Rawalpindiarticlechondroblastomadog 1giant cell tumorchondromyxoid fibromaMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 70, Iss 6, Pp 1825-1829 (2020) |
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chondroblastoma dog 1 giant cell tumor chondromyxoid fibroma Medicine R Medicine (General) R5-920 |
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chondroblastoma dog 1 giant cell tumor chondromyxoid fibroma Medicine R Medicine (General) R5-920 Maryam Nisar Sajid Mushtaq Usman Hassan Noreen Akhtar Muhammad Azam The DOG 1 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF CHONDROBLASTOMAS AND ITS HISTOLOGICAL MIMICKERS |
description |
Objective: Chondroblastoma is rare benign cartilage forming tumor of bone predominantly in individuals less than 20 years of age. Recently immunohistochemical marker DOG 1 has been reported to help in the diagnosis in difficult cases where histological features overlap with other similar entities. Current study aims to assess the sensitivity and specificity of DOG 1 in the diagnosis of chondroblastomas.
Study design: descriptive cross-sectional study
Place and duration of study: The study was conducted from June 2015 to July 2017 in Department of Histopathology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
Patients and methods: Total fifty-two patients were included in this study including 19 chondroblastomas, 21 giant cell tumors and 12 chondromyxoid fibromas. DOG 1 antibody was applied on all the cases
Results: DOG 1 was positive in 100 % of cases of chondroblastomas. However, intensity and proportion of staining pattern was variable among them. 78% (n=15) cases showed diffuse moderate to strong expression while 22% (n=4) cases showed focal weak expression. Only 10% (n=2) cases of giant cell tumors and 33% (n=4) of chondromyxoid fibromas expressed focal weak expression for DOG 1.
Conclusions: This study confirms 100 % expression of DOG 1 in cases of chondroblastomas but intensity and proportion of staining pattern was variable. Therefore DOG 1 may prove to be a useful immunohistochemical marker for diagnosis of chondroblastomas in the future in difficult cases in correlation with histological and radiological features. |
format |
article |
author |
Maryam Nisar Sajid Mushtaq Usman Hassan Noreen Akhtar Muhammad Azam |
author_facet |
Maryam Nisar Sajid Mushtaq Usman Hassan Noreen Akhtar Muhammad Azam |
author_sort |
Maryam Nisar |
title |
The DOG 1 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF CHONDROBLASTOMAS AND ITS HISTOLOGICAL MIMICKERS |
title_short |
The DOG 1 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF CHONDROBLASTOMAS AND ITS HISTOLOGICAL MIMICKERS |
title_full |
The DOG 1 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF CHONDROBLASTOMAS AND ITS HISTOLOGICAL MIMICKERS |
title_fullStr |
The DOG 1 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF CHONDROBLASTOMAS AND ITS HISTOLOGICAL MIMICKERS |
title_full_unstemmed |
The DOG 1 EXPRESSION IN DIFFERENTIAL DIAGNOSIS OF CHONDROBLASTOMAS AND ITS HISTOLOGICAL MIMICKERS |
title_sort |
dog 1 expression in differential diagnosis of chondroblastomas and its histological mimickers |
publisher |
Army Medical College Rawalpindi |
publishDate |
2020 |
url |
https://doaj.org/article/a492839beea3449ca51a5d7ade1fc320 |
work_keys_str_mv |
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