Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions

Alcohol abuse is a risk factor for acute respiratory distress syndrome, flooding of the lungs due to compromised barrier function. Here the authors report that alcohol upregulates claudin-5 that is then recruited to tight junctions in alveolar epithelial cells, causing the displacement of claudin-18...

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Autores principales:	Barbara Schlingmann, Christian E. Overgaard, Samuel A. Molina, K. Sabrina Lynn, Leslie A. Mitchell, StevenClaude Dorsainvil White, Alexa L. Mattheyses, David M. Guidot, Christopher T. Capaldo, Michael Koval
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a496d44daea84ffd8ac69b4def97a4bf
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spelling	oai:doaj.org-article:a496d44daea84ffd8ac69b4def97a4bf2021-12-02T17:32:07ZRegulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions10.1038/ncomms122762041-1723https://doaj.org/article/a496d44daea84ffd8ac69b4def97a4bf2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12276https://doaj.org/toc/2041-1723Alcohol abuse is a risk factor for acute respiratory distress syndrome, flooding of the lungs due to compromised barrier function. Here the authors report that alcohol upregulates claudin-5 that is then recruited to tight junctions in alveolar epithelial cells, causing the displacement of claudin-18 from ZO-1 and diminished barrier function.Barbara SchlingmannChristian E. OvergaardSamuel A. MolinaK. Sabrina LynnLeslie A. MitchellStevenClaude Dorsainvil WhiteAlexa L. MattheysesDavid M. GuidotChristopher T. CapaldoMichael KovalNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Barbara Schlingmann Christian E. Overgaard Samuel A. Molina K. Sabrina Lynn Leslie A. Mitchell StevenClaude Dorsainvil White Alexa L. Mattheyses David M. Guidot Christopher T. Capaldo Michael Koval Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions
description	Alcohol abuse is a risk factor for acute respiratory distress syndrome, flooding of the lungs due to compromised barrier function. Here the authors report that alcohol upregulates claudin-5 that is then recruited to tight junctions in alveolar epithelial cells, causing the displacement of claudin-18 from ZO-1 and diminished barrier function.
format	article
author	Barbara Schlingmann Christian E. Overgaard Samuel A. Molina K. Sabrina Lynn Leslie A. Mitchell StevenClaude Dorsainvil White Alexa L. Mattheyses David M. Guidot Christopher T. Capaldo Michael Koval
author_facet	Barbara Schlingmann Christian E. Overgaard Samuel A. Molina K. Sabrina Lynn Leslie A. Mitchell StevenClaude Dorsainvil White Alexa L. Mattheyses David M. Guidot Christopher T. Capaldo Michael Koval
author_sort	Barbara Schlingmann
title	Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions
title_short	Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions
title_full	Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions
title_fullStr	Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions
title_full_unstemmed	Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions
title_sort	regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/a496d44daea84ffd8ac69b4def97a4bf
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Regulation of claudin/zonula occludens-1 complexes by hetero-claudin interactions

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