Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components

The mitochondrial RNA degradosome (mtEXO) plays an essential role in the regulation of mitochondrial gene expression and is composed of the 3′-to-5′ exoribonuclease Dss1 and the helicase Suv3. Here the authors present the RNA bound mtEXO crystal structure and give insights into its mechanism.

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Autores principales:	Michal Razew, Zbigniew Warkocki, Michal Taube, Adam Kolondra, Mariusz Czarnocki-Cieciura, Elzbieta Nowak, Karolina Labedzka-Dmoch, Aleksandra Kawinska, Jakub Piatkowski, Pawel Golik, Maciej Kozak, Andrzej Dziembowski, Marcin Nowotny
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a49d6a6a537d4790acaf1b909466f3e5
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spelling	oai:doaj.org-article:a49d6a6a537d4790acaf1b909466f3e52021-12-02T15:34:01ZStructural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components10.1038/s41467-017-02570-52041-1723https://doaj.org/article/a49d6a6a537d4790acaf1b909466f3e52018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02570-5https://doaj.org/toc/2041-1723The mitochondrial RNA degradosome (mtEXO) plays an essential role in the regulation of mitochondrial gene expression and is composed of the 3′-to-5′ exoribonuclease Dss1 and the helicase Suv3. Here the authors present the RNA bound mtEXO crystal structure and give insights into its mechanism.Michal RazewZbigniew WarkockiMichal TaubeAdam KolondraMariusz Czarnocki-CieciuraElzbieta NowakKarolina Labedzka-DmochAleksandra KawinskaJakub PiatkowskiPawel GolikMaciej KozakAndrzej DziembowskiMarcin NowotnyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michal Razew Zbigniew Warkocki Michal Taube Adam Kolondra Mariusz Czarnocki-Cieciura Elzbieta Nowak Karolina Labedzka-Dmoch Aleksandra Kawinska Jakub Piatkowski Pawel Golik Maciej Kozak Andrzej Dziembowski Marcin Nowotny Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components
description	The mitochondrial RNA degradosome (mtEXO) plays an essential role in the regulation of mitochondrial gene expression and is composed of the 3′-to-5′ exoribonuclease Dss1 and the helicase Suv3. Here the authors present the RNA bound mtEXO crystal structure and give insights into its mechanism.
format	article
author	Michal Razew Zbigniew Warkocki Michal Taube Adam Kolondra Mariusz Czarnocki-Cieciura Elzbieta Nowak Karolina Labedzka-Dmoch Aleksandra Kawinska Jakub Piatkowski Pawel Golik Maciej Kozak Andrzej Dziembowski Marcin Nowotny
author_facet	Michal Razew Zbigniew Warkocki Michal Taube Adam Kolondra Mariusz Czarnocki-Cieciura Elzbieta Nowak Karolina Labedzka-Dmoch Aleksandra Kawinska Jakub Piatkowski Pawel Golik Maciej Kozak Andrzej Dziembowski Marcin Nowotny
author_sort	Michal Razew
title	Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components
title_short	Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components
title_full	Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components
title_fullStr	Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components
title_full_unstemmed	Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components
title_sort	structural analysis of mtexo mitochondrial rna degradosome reveals tight coupling of nuclease and helicase components
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a49d6a6a537d4790acaf1b909466f3e5
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Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components

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