Tenofovir Disoproxil Fumarate-Associated Renal Dysfunction Among Adult People Living with HIV at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2019: A Comparative Retrospective Cohort Study

Simachew Gidey Debeb,1 Achenef Asmamaw Muche,2 Zemene Demelash Kifle,3 Faisel Dula Sema1 1Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Epidemiology and Biostatistics, Institute of Public Health, C...

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Autores principales:	Debeb SG, Muche AA, Kifle ZD, Sema FD
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	antiretroviral therapy renal dysfunction tenofovir disoproxil fumarate estimated glomerular filtration rate northwest ethiopia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/a4a180fc586848999b0dd155f1d70a8e
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spelling	oai:doaj.org-article:a4a180fc586848999b0dd155f1d70a8e2021-12-02T16:58:10ZTenofovir Disoproxil Fumarate-Associated Renal Dysfunction Among Adult People Living with HIV at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2019: A Comparative Retrospective Cohort Study1179-1373https://doaj.org/article/a4a180fc586848999b0dd155f1d70a8e2021-05-01T00:00:00Zhttps://www.dovepress.com/tenofovir-disoproxil-fumarate-associated-renal-dysfunction-among-adult-peer-reviewed-fulltext-article-HIVhttps://doaj.org/toc/1179-1373Simachew Gidey Debeb,1 Achenef Asmamaw Muche,2 Zemene Demelash Kifle,3 Faisel Dula Sema1 1Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 3Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Faisel Dula Sema Tel +251912805424Email Faiselye1203@gmail.comBackground: The use of tenofovir disoproxil fumarate (TDF) has been reported to be a significant contributor to renal dysfunction. However, patients in Ethiopia may be different than in other parts of the world, and findings from such studies may not apply in this setting.Objective: This study aimed to assess TDF-associated renal dysfunction among adult people living with HIV (PLHIV) at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.Methods: This retrospective cohort study included adult PLHIV between January 2015 and June 2019. The Chronic Kidney Disease Epidemiology (CKD-EPI) equation was used to estimate glomerular filtration rate (eGFR). Renal dysfunction was defined as eGFR < 60 mL/min/1.73 m2. Data were entered into Epi Info™ 7 and analyzed by using SPSS® software version 20. The Kaplan–Meier method was used to estimate the survival curves. Cox proportional hazards models were used to identify predictors of renal dysfunction using a 95% confidence interval and p-value ≤ 0.05 as a statistical significance.Results: Out of 400 participants, 200 were TDF-based ART groups, and 200 were non-TDF-based ART groups. The incidence of renal dysfunction of TDF and the non-TDF group was 28.31 per 100 person-years (PYs) and 12.53 per 100 PYs, respectively. Adult PLHIV taking TDF-based regimens were 1.70 (adjusted HR = 1.70; 95% CI = 1.02– 2.82) times at higher risk of renal dysfunction than non-TDF-based regimens. Age ≥ 55, diabetes mellitus, concurrent nephrotoxic drug use, and combined use of ritonavir-boosted protease inhibitors were also associated significantly with renal dysfunction.Conclusion: The incidence rate of renal dysfunction among TDF users is higher than non-TDF users. Exposure to TDF is a significant risk of renal dysfunction in adult PLHIV. Clinicians should regularly monitor the renal function of adult PLHIV who are taking TDF.Keywords: antiretroviral therapy, renal dysfunction, tenofovir disoproxil fumarate, estimated glomerular filtration rate, northwest EthiopiaDebeb SGMuche AAKifle ZDSema FDDove Medical Pressarticleantiretroviral therapyrenal dysfunctiontenofovir disoproxil fumarateestimated glomerular filtration ratenorthwest ethiopiaImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 13, Pp 491-503 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antiretroviral therapy renal dysfunction tenofovir disoproxil fumarate estimated glomerular filtration rate northwest ethiopia Immunologic diseases. Allergy RC581-607
spellingShingle	antiretroviral therapy renal dysfunction tenofovir disoproxil fumarate estimated glomerular filtration rate northwest ethiopia Immunologic diseases. Allergy RC581-607 Debeb SG Muche AA Kifle ZD Sema FD Tenofovir Disoproxil Fumarate-Associated Renal Dysfunction Among Adult People Living with HIV at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2019: A Comparative Retrospective Cohort Study
description	Simachew Gidey Debeb,1 Achenef Asmamaw Muche,2 Zemene Demelash Kifle,3 Faisel Dula Sema1 1Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 2Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia; 3Department of Pharmacology, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Faisel Dula Sema Tel +251912805424Email Faiselye1203@gmail.comBackground: The use of tenofovir disoproxil fumarate (TDF) has been reported to be a significant contributor to renal dysfunction. However, patients in Ethiopia may be different than in other parts of the world, and findings from such studies may not apply in this setting.Objective: This study aimed to assess TDF-associated renal dysfunction among adult people living with HIV (PLHIV) at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia.Methods: This retrospective cohort study included adult PLHIV between January 2015 and June 2019. The Chronic Kidney Disease Epidemiology (CKD-EPI) equation was used to estimate glomerular filtration rate (eGFR). Renal dysfunction was defined as eGFR < 60 mL/min/1.73 m2. Data were entered into Epi Info™ 7 and analyzed by using SPSS® software version 20. The Kaplan–Meier method was used to estimate the survival curves. Cox proportional hazards models were used to identify predictors of renal dysfunction using a 95% confidence interval and p-value ≤ 0.05 as a statistical significance.Results: Out of 400 participants, 200 were TDF-based ART groups, and 200 were non-TDF-based ART groups. The incidence of renal dysfunction of TDF and the non-TDF group was 28.31 per 100 person-years (PYs) and 12.53 per 100 PYs, respectively. Adult PLHIV taking TDF-based regimens were 1.70 (adjusted HR = 1.70; 95% CI = 1.02– 2.82) times at higher risk of renal dysfunction than non-TDF-based regimens. Age ≥ 55, diabetes mellitus, concurrent nephrotoxic drug use, and combined use of ritonavir-boosted protease inhibitors were also associated significantly with renal dysfunction.Conclusion: The incidence rate of renal dysfunction among TDF users is higher than non-TDF users. Exposure to TDF is a significant risk of renal dysfunction in adult PLHIV. Clinicians should regularly monitor the renal function of adult PLHIV who are taking TDF.Keywords: antiretroviral therapy, renal dysfunction, tenofovir disoproxil fumarate, estimated glomerular filtration rate, northwest Ethiopia
format	article
author	Debeb SG Muche AA Kifle ZD Sema FD
author_facet	Debeb SG Muche AA Kifle ZD Sema FD
author_sort	Debeb SG
title	Tenofovir Disoproxil Fumarate-Associated Renal Dysfunction Among Adult People Living with HIV at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2019: A Comparative Retrospective Cohort Study
title_short	Tenofovir Disoproxil Fumarate-Associated Renal Dysfunction Among Adult People Living with HIV at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2019: A Comparative Retrospective Cohort Study
title_full	Tenofovir Disoproxil Fumarate-Associated Renal Dysfunction Among Adult People Living with HIV at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2019: A Comparative Retrospective Cohort Study
title_fullStr	Tenofovir Disoproxil Fumarate-Associated Renal Dysfunction Among Adult People Living with HIV at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2019: A Comparative Retrospective Cohort Study
title_full_unstemmed	Tenofovir Disoproxil Fumarate-Associated Renal Dysfunction Among Adult People Living with HIV at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2019: A Comparative Retrospective Cohort Study
title_sort	tenofovir disoproxil fumarate-associated renal dysfunction among adult people living with hiv at the university of gondar comprehensive specialized hospital, northwest ethiopia, 2019: a comparative retrospective cohort study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/a4a180fc586848999b0dd155f1d70a8e
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Tenofovir Disoproxil Fumarate-Associated Renal Dysfunction Among Adult People Living with HIV at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2019: A Comparative Retrospective Cohort Study

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