Colorectal cancers from distinct ancestral populations show variations in BRAF mutation frequency.
It has been demonstrated for some cancers that the frequency of somatic oncogenic mutations may vary in ancestral populations. To determine whether key driver alterations might occur at different frequencies in colorectal cancer, we applied a high-throughput genotyping platform (OncoMap) to query 38...
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oai:doaj.org-article:a4a1da8169604c15b81e8f98eabbb7dd2021-11-18T08:55:01ZColorectal cancers from distinct ancestral populations show variations in BRAF mutation frequency.1932-620310.1371/journal.pone.0074950https://doaj.org/article/a4a1da8169604c15b81e8f98eabbb7dd2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24066160/?tool=EBIhttps://doaj.org/toc/1932-6203It has been demonstrated for some cancers that the frequency of somatic oncogenic mutations may vary in ancestral populations. To determine whether key driver alterations might occur at different frequencies in colorectal cancer, we applied a high-throughput genotyping platform (OncoMap) to query 385 mutations across 33 known cancer genes in colorectal cancer DNA from 83 Asian, 149 Black and 195 White patients. We found that Asian patients had fewer canonical oncogenic mutations in the genes tested (60% vs Black 79% (P = 0.011) and White 77% (P = 0.015)), and that BRAF mutations occurred at a higher frequency in White patients (17% vs Asian 4% (P = 0.004) and Black 7% (P = 0.014)). These results suggest that the use of genomic approaches to elucidate the different ancestral determinants harbored by patient populations may help to more precisely and effectively treat colorectal cancer.Megan C HannaChristina GoChristine RodenRobert T JonesPanisa PochanardAhmed Yasir JavedAwais JavedChandrani MondalEmanuele PalescandoloPaul Van HummelenCharles HattonAdam J BassSung Min ChunDeuk Chae NaTae-Im KimSe Jin JangRaymond U OsarogiagbonWilliam C HahnMatthew MeyersonLevi A GarrawayLaura E MacConaillPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e74950 (2013) |
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Medicine R Science Q |
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Medicine R Science Q Megan C Hanna Christina Go Christine Roden Robert T Jones Panisa Pochanard Ahmed Yasir Javed Awais Javed Chandrani Mondal Emanuele Palescandolo Paul Van Hummelen Charles Hatton Adam J Bass Sung Min Chun Deuk Chae Na Tae-Im Kim Se Jin Jang Raymond U Osarogiagbon William C Hahn Matthew Meyerson Levi A Garraway Laura E MacConaill Colorectal cancers from distinct ancestral populations show variations in BRAF mutation frequency. |
| description |
It has been demonstrated for some cancers that the frequency of somatic oncogenic mutations may vary in ancestral populations. To determine whether key driver alterations might occur at different frequencies in colorectal cancer, we applied a high-throughput genotyping platform (OncoMap) to query 385 mutations across 33 known cancer genes in colorectal cancer DNA from 83 Asian, 149 Black and 195 White patients. We found that Asian patients had fewer canonical oncogenic mutations in the genes tested (60% vs Black 79% (P = 0.011) and White 77% (P = 0.015)), and that BRAF mutations occurred at a higher frequency in White patients (17% vs Asian 4% (P = 0.004) and Black 7% (P = 0.014)). These results suggest that the use of genomic approaches to elucidate the different ancestral determinants harbored by patient populations may help to more precisely and effectively treat colorectal cancer. |
| format |
article |
| author |
Megan C Hanna Christina Go Christine Roden Robert T Jones Panisa Pochanard Ahmed Yasir Javed Awais Javed Chandrani Mondal Emanuele Palescandolo Paul Van Hummelen Charles Hatton Adam J Bass Sung Min Chun Deuk Chae Na Tae-Im Kim Se Jin Jang Raymond U Osarogiagbon William C Hahn Matthew Meyerson Levi A Garraway Laura E MacConaill |
| author_facet |
Megan C Hanna Christina Go Christine Roden Robert T Jones Panisa Pochanard Ahmed Yasir Javed Awais Javed Chandrani Mondal Emanuele Palescandolo Paul Van Hummelen Charles Hatton Adam J Bass Sung Min Chun Deuk Chae Na Tae-Im Kim Se Jin Jang Raymond U Osarogiagbon William C Hahn Matthew Meyerson Levi A Garraway Laura E MacConaill |
| author_sort |
Megan C Hanna |
| title |
Colorectal cancers from distinct ancestral populations show variations in BRAF mutation frequency. |
| title_short |
Colorectal cancers from distinct ancestral populations show variations in BRAF mutation frequency. |
| title_full |
Colorectal cancers from distinct ancestral populations show variations in BRAF mutation frequency. |
| title_fullStr |
Colorectal cancers from distinct ancestral populations show variations in BRAF mutation frequency. |
| title_full_unstemmed |
Colorectal cancers from distinct ancestral populations show variations in BRAF mutation frequency. |
| title_sort |
colorectal cancers from distinct ancestral populations show variations in braf mutation frequency. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/a4a1da8169604c15b81e8f98eabbb7dd |
| work_keys_str_mv |
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