Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway

SIRTs have been reported to provide neuroprotective actions in polyglutamine diseases, and are linked to the beneficial effects of caloric restrictive diets. Here, the authors show caloric restriction improves behavioural and neuropathological deficits in MJD model mice, an effect dependent on SIRT1...

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Autores principales:	Janete Cunha-Santos, Joana Duarte-Neves, Vitor Carmona, Leonard Guarente, Luís Pereira de Almeida, Cláudia Cavadas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a4a2d4276c134fcebdf4609415741326
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spelling	oai:doaj.org-article:a4a2d4276c134fcebdf46094157413262021-12-02T17:32:51ZCaloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway10.1038/ncomms114452041-1723https://doaj.org/article/a4a2d4276c134fcebdf46094157413262016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11445https://doaj.org/toc/2041-1723SIRTs have been reported to provide neuroprotective actions in polyglutamine diseases, and are linked to the beneficial effects of caloric restrictive diets. Here, the authors show caloric restriction improves behavioural and neuropathological deficits in MJD model mice, an effect dependent on SIRT1 activity.Janete Cunha-SantosJoana Duarte-NevesVitor CarmonaLeonard GuarenteLuís Pereira de AlmeidaCláudia CavadasNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Janete Cunha-Santos Joana Duarte-Neves Vitor Carmona Leonard Guarente Luís Pereira de Almeida Cláudia Cavadas Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway
description	SIRTs have been reported to provide neuroprotective actions in polyglutamine diseases, and are linked to the beneficial effects of caloric restrictive diets. Here, the authors show caloric restriction improves behavioural and neuropathological deficits in MJD model mice, an effect dependent on SIRT1 activity.
format	article
author	Janete Cunha-Santos Joana Duarte-Neves Vitor Carmona Leonard Guarente Luís Pereira de Almeida Cláudia Cavadas
author_facet	Janete Cunha-Santos Joana Duarte-Neves Vitor Carmona Leonard Guarente Luís Pereira de Almeida Cláudia Cavadas
author_sort	Janete Cunha-Santos
title	Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway
title_short	Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway
title_full	Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway
title_fullStr	Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway
title_full_unstemmed	Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway
title_sort	caloric restriction blocks neuropathology and motor deficits in machado–joseph disease mouse models through sirt1 pathway
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/a4a2d4276c134fcebdf4609415741326
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Caloric restriction blocks neuropathology and motor deficits in Machado–Joseph disease mouse models through SIRT1 pathway

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