Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling

The truncated form of retinoid X receptor-alpha is found in cancer. Here, the authors show that this mutant receptor promotes colorectal tumorigenesis by activation of NF-κB in myeloid cells, leading to subsequent IL-6-induced STAT3 activation in intestinal epithelial cells, which can be suppressed...

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Autores principales:	Xiaohong Ye, Hua Wu, Luoyan Sheng, Yi-xin Liu, Fang Ye, Mo Wang, Hu Zhou, Ying Su, Xiao-kun Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a4a4156e6edb46bf9b3d8090fdc091b6
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spelling	oai:doaj.org-article:a4a4156e6edb46bf9b3d8090fdc091b62021-12-02T17:01:52ZOncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling10.1038/s41467-019-09375-82041-1723https://doaj.org/article/a4a4156e6edb46bf9b3d8090fdc091b62019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09375-8https://doaj.org/toc/2041-1723The truncated form of retinoid X receptor-alpha is found in cancer. Here, the authors show that this mutant receptor promotes colorectal tumorigenesis by activation of NF-κB in myeloid cells, leading to subsequent IL-6-induced STAT3 activation in intestinal epithelial cells, which can be suppressed by ligand K-80003.Xiaohong YeHua WuLuoyan ShengYi-xin LiuFang YeMo WangHu ZhouYing SuXiao-kun ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaohong Ye Hua Wu Luoyan Sheng Yi-xin Liu Fang Ye Mo Wang Hu Zhou Ying Su Xiao-kun Zhang Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling
description	The truncated form of retinoid X receptor-alpha is found in cancer. Here, the authors show that this mutant receptor promotes colorectal tumorigenesis by activation of NF-κB in myeloid cells, leading to subsequent IL-6-induced STAT3 activation in intestinal epithelial cells, which can be suppressed by ligand K-80003.
format	article
author	Xiaohong Ye Hua Wu Luoyan Sheng Yi-xin Liu Fang Ye Mo Wang Hu Zhou Ying Su Xiao-kun Zhang
author_facet	Xiaohong Ye Hua Wu Luoyan Sheng Yi-xin Liu Fang Ye Mo Wang Hu Zhou Ying Su Xiao-kun Zhang
author_sort	Xiaohong Ye
title	Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling
title_short	Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling
title_full	Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling
title_fullStr	Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling
title_full_unstemmed	Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling
title_sort	oncogenic potential of truncated rxrα during colitis-associated colorectal tumorigenesis by promoting il-6-stat3 signaling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a4a4156e6edb46bf9b3d8090fdc091b6
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Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling

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