Necrotrophic growth of periodontopathogens is a novel virulence factor in oral biofilms

Abstract The oral use of antimicrobial agents embedded in toothpastes and mouth rinses results in an oral microbial massacre with high amounts of dead bacteria in close proximity to few surviving bacteria. It was hypothesized that this provides the surviving pathogenic bacteria a large amount of dea...

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Autores principales:	Esteban Rodriguez Herrero, Nico Boon, Martine Pauwels, Kristel Bernaerts, Vera Slomka, Marc Quirynen, Wim Teughels
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a4a4224de62d4dfbaa7b6d65622e3bd5
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spelling	oai:doaj.org-article:a4a4224de62d4dfbaa7b6d65622e3bd52021-12-02T16:07:05ZNecrotrophic growth of periodontopathogens is a novel virulence factor in oral biofilms10.1038/s41598-017-01239-92045-2322https://doaj.org/article/a4a4224de62d4dfbaa7b6d65622e3bd52017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01239-9https://doaj.org/toc/2045-2322Abstract The oral use of antimicrobial agents embedded in toothpastes and mouth rinses results in an oral microbial massacre with high amounts of dead bacteria in close proximity to few surviving bacteria. It was hypothesized that this provides the surviving pathogenic bacteria a large amount of dead microbial biomass as a nutritional source for growth (necrotrophy). This study demonstrated the necrotrophic growth of periodontal pathogens in the presence of different dead oral species. In addition, the presence of dead bacteria resulted in an outgrowth of several periodontal pathogens in complex multi-species biofilms. Additionally, upon contact with dead oral bacteria, virulence genes of P. intermedia and P. gingivalis were up-regulated (necrovirulence). This resulted in a more pronounced epithelial cytotoxicity (necrotoxicity). These findings indicate that presence of dead bacteria induce necrotrophy, necrovirulence and necrotoxicity in several oral pathogens.Esteban Rodriguez HerreroNico BoonMartine PauwelsKristel BernaertsVera SlomkaMarc QuirynenWim TeughelsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Esteban Rodriguez Herrero Nico Boon Martine Pauwels Kristel Bernaerts Vera Slomka Marc Quirynen Wim Teughels Necrotrophic growth of periodontopathogens is a novel virulence factor in oral biofilms
description	Abstract The oral use of antimicrobial agents embedded in toothpastes and mouth rinses results in an oral microbial massacre with high amounts of dead bacteria in close proximity to few surviving bacteria. It was hypothesized that this provides the surviving pathogenic bacteria a large amount of dead microbial biomass as a nutritional source for growth (necrotrophy). This study demonstrated the necrotrophic growth of periodontal pathogens in the presence of different dead oral species. In addition, the presence of dead bacteria resulted in an outgrowth of several periodontal pathogens in complex multi-species biofilms. Additionally, upon contact with dead oral bacteria, virulence genes of P. intermedia and P. gingivalis were up-regulated (necrovirulence). This resulted in a more pronounced epithelial cytotoxicity (necrotoxicity). These findings indicate that presence of dead bacteria induce necrotrophy, necrovirulence and necrotoxicity in several oral pathogens.
format	article
author	Esteban Rodriguez Herrero Nico Boon Martine Pauwels Kristel Bernaerts Vera Slomka Marc Quirynen Wim Teughels
author_facet	Esteban Rodriguez Herrero Nico Boon Martine Pauwels Kristel Bernaerts Vera Slomka Marc Quirynen Wim Teughels
author_sort	Esteban Rodriguez Herrero
title	Necrotrophic growth of periodontopathogens is a novel virulence factor in oral biofilms
title_short	Necrotrophic growth of periodontopathogens is a novel virulence factor in oral biofilms
title_full	Necrotrophic growth of periodontopathogens is a novel virulence factor in oral biofilms
title_fullStr	Necrotrophic growth of periodontopathogens is a novel virulence factor in oral biofilms
title_full_unstemmed	Necrotrophic growth of periodontopathogens is a novel virulence factor in oral biofilms
title_sort	necrotrophic growth of periodontopathogens is a novel virulence factor in oral biofilms
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a4a4224de62d4dfbaa7b6d65622e3bd5
work_keys_str_mv	AT estebanrodriguezherrero necrotrophicgrowthofperiodontopathogensisanovelvirulencefactorinoralbiofilms AT nicoboon necrotrophicgrowthofperiodontopathogensisanovelvirulencefactorinoralbiofilms AT martinepauwels necrotrophicgrowthofperiodontopathogensisanovelvirulencefactorinoralbiofilms AT kristelbernaerts necrotrophicgrowthofperiodontopathogensisanovelvirulencefactorinoralbiofilms AT veraslomka necrotrophicgrowthofperiodontopathogensisanovelvirulencefactorinoralbiofilms AT marcquirynen necrotrophicgrowthofperiodontopathogensisanovelvirulencefactorinoralbiofilms AT wimteughels necrotrophicgrowthofperiodontopathogensisanovelvirulencefactorinoralbiofilms
_version_	1718384734680121344

Necrotrophic growth of periodontopathogens is a novel virulence factor in oral biofilms

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