A Facile Strategy for the Ion Current and Fluorescence Dual-Lock in Detection: Naphthalic Anhydride Azide (NAA)-Modified Biomimetic Nanochannel Sensor towards H<sub>2</sub>S

Inspired by biological channels, the electric signal-based artificial nanochannel system exhibits high sensitivity in various analyses. However, ion current may be affected by many other factors, leading to false-positive signals. For reliable detection, in this work, we apply a facile strategy to c...

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Autores principales:	I Wu, Dan Zhang, Xuanjun Zhang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	biomimetic nanochannels current fluorescence dual-signal sensing H<sub>2</sub>S Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/a4a85ebbdcd84d7f8689daac5b186a2c
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spelling	oai:doaj.org-article:a4a85ebbdcd84d7f8689daac5b186a2c2021-11-25T17:13:30ZA Facile Strategy for the Ion Current and Fluorescence Dual-Lock in Detection: Naphthalic Anhydride Azide (NAA)-Modified Biomimetic Nanochannel Sensor towards H<sub>2</sub>S10.3390/chemosensors91102982227-9040https://doaj.org/article/a4a85ebbdcd84d7f8689daac5b186a2c2021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9040/9/11/298https://doaj.org/toc/2227-9040Inspired by biological channels, the electric signal-based artificial nanochannel system exhibits high sensitivity in various analyses. However, ion current may be affected by many other factors, leading to false-positive signals. For reliable detection, in this work, we apply a facile strategy to combine both current signal and fluorescence. Fluorescent probes were conjugated to the nanochannel surface by covalent bonds. By utilizing the specific reduction of azide groups in the probe to amino groups by H<sub>2</sub>S, a synchronizing change in fluorescence and nanochannel surface charge was established. As a result, both transmembrane ion current and fluorescence intensity showed significant changes. The photoelectric double-checked locking from temporal and spatial variation validly confirmed the response process and protected detection accuracy. The work may provide new ideas for the development of more sophisticated current and fluorescence dual-index nanochannel systems.I WuDan ZhangXuanjun ZhangMDPI AGarticlebiomimetic nanochannelscurrentfluorescencedual-signal sensingH<sub>2</sub>SBiochemistryQD415-436ENChemosensors, Vol 9, Iss 298, p 298 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biomimetic nanochannels current fluorescence dual-signal sensing H<sub>2</sub>S Biochemistry QD415-436
spellingShingle	biomimetic nanochannels current fluorescence dual-signal sensing H<sub>2</sub>S Biochemistry QD415-436 I Wu Dan Zhang Xuanjun Zhang A Facile Strategy for the Ion Current and Fluorescence Dual-Lock in Detection: Naphthalic Anhydride Azide (NAA)-Modified Biomimetic Nanochannel Sensor towards H<sub>2</sub>S
description	Inspired by biological channels, the electric signal-based artificial nanochannel system exhibits high sensitivity in various analyses. However, ion current may be affected by many other factors, leading to false-positive signals. For reliable detection, in this work, we apply a facile strategy to combine both current signal and fluorescence. Fluorescent probes were conjugated to the nanochannel surface by covalent bonds. By utilizing the specific reduction of azide groups in the probe to amino groups by H<sub>2</sub>S, a synchronizing change in fluorescence and nanochannel surface charge was established. As a result, both transmembrane ion current and fluorescence intensity showed significant changes. The photoelectric double-checked locking from temporal and spatial variation validly confirmed the response process and protected detection accuracy. The work may provide new ideas for the development of more sophisticated current and fluorescence dual-index nanochannel systems.
format	article
author	I Wu Dan Zhang Xuanjun Zhang
author_facet	I Wu Dan Zhang Xuanjun Zhang
author_sort	I Wu
title	A Facile Strategy for the Ion Current and Fluorescence Dual-Lock in Detection: Naphthalic Anhydride Azide (NAA)-Modified Biomimetic Nanochannel Sensor towards H<sub>2</sub>S
title_short	A Facile Strategy for the Ion Current and Fluorescence Dual-Lock in Detection: Naphthalic Anhydride Azide (NAA)-Modified Biomimetic Nanochannel Sensor towards H<sub>2</sub>S
title_full	A Facile Strategy for the Ion Current and Fluorescence Dual-Lock in Detection: Naphthalic Anhydride Azide (NAA)-Modified Biomimetic Nanochannel Sensor towards H<sub>2</sub>S
title_fullStr	A Facile Strategy for the Ion Current and Fluorescence Dual-Lock in Detection: Naphthalic Anhydride Azide (NAA)-Modified Biomimetic Nanochannel Sensor towards H<sub>2</sub>S
title_full_unstemmed	A Facile Strategy for the Ion Current and Fluorescence Dual-Lock in Detection: Naphthalic Anhydride Azide (NAA)-Modified Biomimetic Nanochannel Sensor towards H<sub>2</sub>S
title_sort	facile strategy for the ion current and fluorescence dual-lock in detection: naphthalic anhydride azide (naa)-modified biomimetic nanochannel sensor towards h<sub>2</sub>s
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a4a85ebbdcd84d7f8689daac5b186a2c
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A Facile Strategy for the Ion Current and Fluorescence Dual-Lock in Detection: Naphthalic Anhydride Azide (NAA)-Modified Biomimetic Nanochannel Sensor towards H<sub>2</sub>S

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