PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation

PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation

Processing the value of reward is thought to involve the rostromedial caudate (rmCD), but a causal demonstration is lacking in primates. Here the authors use chemogenetics and PET imaging to show that inactivation of rmCD leads to impairments in reward value judgments.

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Bibliographic Details
Main Authors: Yuji Nagai, Erika Kikuchi, Walter Lerchner, Ken-ichi Inoue, Bin Ji, Mark A. G. Eldridge, Hiroyuki Kaneko, Yasuyuki Kimura, Arata Oh-Nishi, Yukiko Hori, Yoko Kato, Toshiyuki Hirabayashi, Atsushi Fujimoto, Katsushi Kumata, Ming-Rong Zhang, Ichio Aoki, Tetsuya Suhara, Makoto Higuchi, Masahiko Takada, Barry J. Richmond, Takafumi Minamimoto
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
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Online Access:https://doaj.org/article/a4aae1fbd9c94e69a28ac3ac20153689
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Summary:Processing the value of reward is thought to involve the rostromedial caudate (rmCD), but a causal demonstration is lacking in primates. Here the authors use chemogenetics and PET imaging to show that inactivation of rmCD leads to impairments in reward value judgments.

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