PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation

Processing the value of reward is thought to involve the rostromedial caudate (rmCD), but a causal demonstration is lacking in primates. Here the authors use chemogenetics and PET imaging to show that inactivation of rmCD leads to impairments in reward value judgments.

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Autores principales:	Yuji Nagai, Erika Kikuchi, Walter Lerchner, Ken-ichi Inoue, Bin Ji, Mark A. G. Eldridge, Hiroyuki Kaneko, Yasuyuki Kimura, Arata Oh-Nishi, Yukiko Hori, Yoko Kato, Toshiyuki Hirabayashi, Atsushi Fujimoto, Katsushi Kumata, Ming-Rong Zhang, Ichio Aoki, Tetsuya Suhara, Makoto Higuchi, Masahiko Takada, Barry J. Richmond, Takafumi Minamimoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a4aae1fbd9c94e69a28ac3ac20153689
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spelling	oai:doaj.org-article:a4aae1fbd9c94e69a28ac3ac201536892021-12-02T15:35:42ZPET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation10.1038/ncomms136052041-1723https://doaj.org/article/a4aae1fbd9c94e69a28ac3ac201536892016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13605https://doaj.org/toc/2041-1723Processing the value of reward is thought to involve the rostromedial caudate (rmCD), but a causal demonstration is lacking in primates. Here the authors use chemogenetics and PET imaging to show that inactivation of rmCD leads to impairments in reward value judgments.Yuji NagaiErika KikuchiWalter LerchnerKen-ichi InoueBin JiMark A. G. EldridgeHiroyuki KanekoYasuyuki KimuraArata Oh-NishiYukiko HoriYoko KatoToshiyuki HirabayashiAtsushi FujimotoKatsushi KumataMing-Rong ZhangIchio AokiTetsuya SuharaMakoto HiguchiMasahiko TakadaBarry J. RichmondTakafumi MinamimotoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuji Nagai Erika Kikuchi Walter Lerchner Ken-ichi Inoue Bin Ji Mark A. G. Eldridge Hiroyuki Kaneko Yasuyuki Kimura Arata Oh-Nishi Yukiko Hori Yoko Kato Toshiyuki Hirabayashi Atsushi Fujimoto Katsushi Kumata Ming-Rong Zhang Ichio Aoki Tetsuya Suhara Makoto Higuchi Masahiko Takada Barry J. Richmond Takafumi Minamimoto PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation
description	Processing the value of reward is thought to involve the rostromedial caudate (rmCD), but a causal demonstration is lacking in primates. Here the authors use chemogenetics and PET imaging to show that inactivation of rmCD leads to impairments in reward value judgments.
format	article
author	Yuji Nagai Erika Kikuchi Walter Lerchner Ken-ichi Inoue Bin Ji Mark A. G. Eldridge Hiroyuki Kaneko Yasuyuki Kimura Arata Oh-Nishi Yukiko Hori Yoko Kato Toshiyuki Hirabayashi Atsushi Fujimoto Katsushi Kumata Ming-Rong Zhang Ichio Aoki Tetsuya Suhara Makoto Higuchi Masahiko Takada Barry J. Richmond Takafumi Minamimoto
author_facet	Yuji Nagai Erika Kikuchi Walter Lerchner Ken-ichi Inoue Bin Ji Mark A. G. Eldridge Hiroyuki Kaneko Yasuyuki Kimura Arata Oh-Nishi Yukiko Hori Yoko Kato Toshiyuki Hirabayashi Atsushi Fujimoto Katsushi Kumata Ming-Rong Zhang Ichio Aoki Tetsuya Suhara Makoto Higuchi Masahiko Takada Barry J. Richmond Takafumi Minamimoto
author_sort	Yuji Nagai
title	PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation
title_short	PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation
title_full	PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation
title_fullStr	PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation
title_full_unstemmed	PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation
title_sort	pet imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/a4aae1fbd9c94e69a28ac3ac20153689
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PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation

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