Thyroid hormone T3 counteracts STZ induced diabetes in mouse.

This study intended to demonstrate that the thyroid hormone T3 counteracts the onset of a Streptozotocin (STZ) induced diabetes in wild type mice. To test our hypothesis diabetes has been induced in Balb/c male mice by multiple low dose Streptozotocin injection; and a group of mice was contemporaneo...

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Autores principales:	Cecilia Verga Falzacappa, Claudia Mangialardo, Luca Madaro, Danilo Ranieri, Lorenzo Lupoi, Antonio Stigliano, Maria Rosaria Torrisi, Marina Bouchè, Vincenzo Toscano, Silvia Misiti
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a4ac7831203e4e238526615cd7df78e4
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spelling	oai:doaj.org-article:a4ac7831203e4e238526615cd7df78e42021-11-18T06:53:04ZThyroid hormone T3 counteracts STZ induced diabetes in mouse.1932-620310.1371/journal.pone.0019839https://doaj.org/article/a4ac7831203e4e238526615cd7df78e42011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21637761/?tool=EBIhttps://doaj.org/toc/1932-6203This study intended to demonstrate that the thyroid hormone T3 counteracts the onset of a Streptozotocin (STZ) induced diabetes in wild type mice. To test our hypothesis diabetes has been induced in Balb/c male mice by multiple low dose Streptozotocin injection; and a group of mice was contemporaneously injected with T3. After 48 h mice were tested for glucose tolerance test, insulin serum levels and then sacrificed. Whole pancreata were utilized for morphological and biochemical analyses, while protein extracts and RNA were utilized for expression analyses of specific molecules. The results showed that islets from T3 treated mice were comparable to age- and sex-matched control, untreated mice in number, shape, dimension, consistency, ultrastructure, insulin and glucagon levels, Tunel positivity and caspases activation, while all the cited parameters and molecules were altered by STZ alone. The T3-induced pro survival effect was associated with a strong increase in phosphorylated Akt. Moreover, T3 administration prevented the STZ-dependent alterations in glucose blood level, both during fasting and after glucose challenge, as well as in insulin serum level. In conclusion we demonstrated that T3 could act as a protective factor against STZ induced diabetes.Cecilia Verga FalzacappaClaudia MangialardoLuca MadaroDanilo RanieriLorenzo LupoiAntonio StiglianoMaria Rosaria TorrisiMarina BouchèVincenzo ToscanoSilvia MisitiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 5, p e19839 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cecilia Verga Falzacappa Claudia Mangialardo Luca Madaro Danilo Ranieri Lorenzo Lupoi Antonio Stigliano Maria Rosaria Torrisi Marina Bouchè Vincenzo Toscano Silvia Misiti Thyroid hormone T3 counteracts STZ induced diabetes in mouse.
description	This study intended to demonstrate that the thyroid hormone T3 counteracts the onset of a Streptozotocin (STZ) induced diabetes in wild type mice. To test our hypothesis diabetes has been induced in Balb/c male mice by multiple low dose Streptozotocin injection; and a group of mice was contemporaneously injected with T3. After 48 h mice were tested for glucose tolerance test, insulin serum levels and then sacrificed. Whole pancreata were utilized for morphological and biochemical analyses, while protein extracts and RNA were utilized for expression analyses of specific molecules. The results showed that islets from T3 treated mice were comparable to age- and sex-matched control, untreated mice in number, shape, dimension, consistency, ultrastructure, insulin and glucagon levels, Tunel positivity and caspases activation, while all the cited parameters and molecules were altered by STZ alone. The T3-induced pro survival effect was associated with a strong increase in phosphorylated Akt. Moreover, T3 administration prevented the STZ-dependent alterations in glucose blood level, both during fasting and after glucose challenge, as well as in insulin serum level. In conclusion we demonstrated that T3 could act as a protective factor against STZ induced diabetes.
format	article
author	Cecilia Verga Falzacappa Claudia Mangialardo Luca Madaro Danilo Ranieri Lorenzo Lupoi Antonio Stigliano Maria Rosaria Torrisi Marina Bouchè Vincenzo Toscano Silvia Misiti
author_facet	Cecilia Verga Falzacappa Claudia Mangialardo Luca Madaro Danilo Ranieri Lorenzo Lupoi Antonio Stigliano Maria Rosaria Torrisi Marina Bouchè Vincenzo Toscano Silvia Misiti
author_sort	Cecilia Verga Falzacappa
title	Thyroid hormone T3 counteracts STZ induced diabetes in mouse.
title_short	Thyroid hormone T3 counteracts STZ induced diabetes in mouse.
title_full	Thyroid hormone T3 counteracts STZ induced diabetes in mouse.
title_fullStr	Thyroid hormone T3 counteracts STZ induced diabetes in mouse.
title_full_unstemmed	Thyroid hormone T3 counteracts STZ induced diabetes in mouse.
title_sort	thyroid hormone t3 counteracts stz induced diabetes in mouse.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/a4ac7831203e4e238526615cd7df78e4
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Thyroid hormone T3 counteracts STZ induced diabetes in mouse.

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